2-Hydroxy-4-methyl-5-nitropyridine
- Product Name
- 2-Hydroxy-4-methyl-5-nitropyridine
- CAS No.
- 21901-41-7
- Chemical Name
- 2-Hydroxy-4-methyl-5-nitropyridine
- Synonyms
- 2-HYDROXY-5-NI;5-NITRO-4-PICOLIN-2-OL;4-METHYL-5-NITRO-2-PYRIDONE;4-METHYL-5-NITRO-2-PYRIDINOL;2-HYDROXY-5-NITRO-4-PICOLINE;4-Methyl-5-nitro-2-pyridinone;2-Hydroxy-4-Methyl-5-Nitropyri;4-METHYL-5-NITRO-2(1H)-PYRIDINONE;4-Methyl-5-nitropyridin-2(1H)-one;4-methyl-5-nitro-1H-pyridin-2-one
- CBNumber
- CB3193376
- Molecular Formula
- C6H6N2O3
- Formula Weight
- 154.12
- MOL File
- 21901-41-7.mol
2-Hydroxy-4-methyl-5-nitropyridine Property
- Melting point:
- 186-190 °C (lit.)
- Boiling point:
- 277.46°C (rough estimate)
- Density
- 1.4564 (rough estimate)
- refractive index
- 1.5100 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Crystalline Powder
- pka
- 8.10±0.10(Predicted)
- color
- Yellow to orange
- BRN
- 136900
- CAS DataBase Reference
- 21901-41-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-37/39-36/37/39-36
- RIDADR
- 2811
- WGK Germany
- 3
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29337900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 290106
- Product name
- 2-Hydroxy-4-methyl-5-nitropyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $185
- Updated
- 2023/01/07
- Product number
- H1050
- Product name
- 2-Hydroxy-4-methyl-5-nitropyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $31
- Updated
- 2025/07/31
- Product number
- H1050
- Product name
- 2-Hydroxy-4-methyl-5-nitropyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $95
- Updated
- 2025/07/31
- Product number
- M218915
- Product name
- 4-Methyl-5-nitro-1,2-dihydropyridin-2-one
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- J93949
- Product name
- 2-Hydroxy-4-methyl-5-nitropyridine
- Packaging
- 5g
- Price
- $12
- Updated
- 2021/12/16
2-Hydroxy-4-methyl-5-nitropyridine Chemical Properties,Usage,Production
Chemical Properties
Orange plates
General Description
The conformational stability and the vibartional analysis of 2-hydroxy-4-methyl-5-nitropyridine was studied.
Synthesis
21901-40-6
21901-41-7
General procedure for the synthesis of 2-hydroxy-4-methyl-5-nitropyridine from 2-amino-4-methyl-5-nitropyridine: 2-amino-4-methyl-5-nitropyridine (10 g, 23 mmol) was weighed and placed in a 250 ml round-bottomed flask, and 70 ml of concentrated sulphuric acid was added to dissolve it until the raw material was completely dissolved. The reaction flask was placed in a cold bath at a low temperature of -5 °C, and a pre-configured aqueous solution of sodium nitrite (NaNO2, 6.76 g) was slowly added dropwise through a constant pressure dropping funnel. A large number of bubbles were generated during the addition, and the rate of titration needed to be controlled to avoid a rapid increase in temperature and to ensure that the reaction temperature did not exceed 0 °C. The reaction was carried out at a constant pressure. A solid was gradually precipitated during the reaction. After dropwise addition, stirring was continued for 10 minutes, and the reaction solution turned orange and clarified. The reaction was continued at 0 °C and the progress of the reaction was monitored by thin layer chromatography (TLC).The reaction was stopped after 3 hours when the TLC showed that the reaction was complete. The reaction solution was slowly poured into a beaker containing about 300 mL of water and a large amount of yellow solid precipitated. After leaving to crystallize for 3 h at room temperature, the solid was collected by filtration and dried under infrared lamp to give 6.72 g of yellow solid product in 67.2% yield.
References
[1] Patent: CN105906621, 2016, A. Location in patent: Paragraph 0045
[2] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 13
[3] Journal of the Chemical Society, 1954, p. 2448,2455
[4] Journal of Organic Chemistry, 1955, vol. 20, p. 1729,1731
[5] Patent: WO2007/53394, 2007, A1. Location in patent: Page/Page column 12
2-Hydroxy-4-methyl-5-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Hydroxy-4-methyl-5-nitropyridine manufacturers
- Product
- 2-Hydroxy-4-methyl-5-nitropyridine 21901-41-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-29
- Product
- 2-Hydroxy-4-methyl-5-nitropyridine 21901-41-7
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-13
- Product
- 2-Hydroxy-4-methyl-5-nitropyridine 21901-41-7
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08