3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID
- Product Name
- 3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID
- CAS No.
- 2267-40-5
- Chemical Name
- 3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID
- Synonyms
- Benzoic acid,3-(chlo;3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID;3-(Chlorosulphonyl)-4-fluorobenzoic acid;Benzoic acid,3-(chlorosulfonyl)-4-fluoro-;5-Carboxy-2-fluorobenzenesulphonyl chloride;2-fluoro-5-carboxybenzenesulphonyl chloride;3-(chlorosulfonyl)-4-fluorobenzoic acid(SALTDATA: FREE)
- CBNumber
- CB3196054
- Molecular Formula
- C7H4ClFO4S
- Formula Weight
- 238.62
- MOL File
- 2267-40-5.mol
3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID Property
- Melting point:
- 147-148℃
- Boiling point:
- 388.6±27.0 °C(Predicted)
- Density
- 1.670±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder
- pka
- 2.94±0.10(Predicted)
- color
- White/off-white
- InChI
- InChI=1S/C7H4ClFO4S/c8-14(12,13)6-3-4(7(10)11)1-2-5(6)9/h1-3H,(H,10,11)
- InChIKey
- LZGZJLJZSAGDKR-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C(F)C(S(Cl)(=O)=O)=C1
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- CDS011580
- Product name
- 3-chlorosulfonyl-4-fluoro-benzoic acid
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 100 mg
- Price
- $185
- Updated
- 2025/07/31
- Product number
- C364488
- Product name
- 3-(Chlorosulfonyl)-4-fluorobenzoicAcid
- Packaging
- 2.5mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 037319
- Product name
- 3-Chlorosulfonyl-4-fluoro-benzoicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
- Product number
- J90122
- Product name
- 3-Chlorosulfonyl-4-fluoro-benzoicacid
- Packaging
- 5g
- Price
- $35
- Updated
- 2021/12/16
- Product number
- 037319
- Product name
- 3-Chlorosulfonyl-4-fluoro-benzoicacid
- Purity
- 97%
- Packaging
- 5g
- Price
- $44
- Updated
- 2021/12/16
3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID Chemical Properties,Usage,Production
Synthesis
456-22-4
2267-40-5
Example 2: Synthesis of 2-fluoro-5-(4-methoxybenzoyl)-benzenesulfonamide; 4-fluorobenzoic acid (8 g, 57 mmol) was slowly added to chlorosulfonic acid (58 g, 498 mmol), followed by sodium chloride (10 g, 169 mmol). After the addition was completed, the reaction mixture was heated at 160°C for 5 hours. After completion of the reaction, the reaction mixture was cooled and slowly poured into ice water. The precipitated white solid precipitate was collected by filtration and redissolved in ethyl acetate. The organic layer was washed with saturated sodium chloride solution, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to remove the solvent. The residue was ground with hexane to give 7 g (51% yield) of the target product as a white solid.1H NMR (CDCl3): δ 8.78 (m, 1H), 8.52 (m, 1H), 7.5 (t, 1H).MS (m/z): 308 (M-1).
References
[1] Patent: US2004/2492, 2004, A1. Location in patent: Page/Page column 48-49
[2] Patent: WO2009/118292, 2009, A1. Location in patent: Page/Page column 42-43
[3] Journal of Medicinal Chemistry, 1997, vol. 40, # 13, p. 2017 - 2034
[4] Bioorganic and medicinal chemistry, 2002, vol. 10, # 3, p. 639 - 656
[5] Journal of Medicinal Chemistry, 2005, vol. 48, # 5, p. 1596 - 1609
3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID manufacturers
- Product
- 3-(chlorosulfonyl)-4-fluorobenzoic acid 2267-40-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-07
- Product
- 3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID 2267-40-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97-99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-18