ChemicalBook > CAS DataBase List > 3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID

3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID

Product Name
3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID
CAS No.
2267-40-5
Chemical Name
3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID
Synonyms
Benzoic acid,3-(chlo;3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID;3-(Chlorosulphonyl)-4-fluorobenzoic acid;Benzoic acid,3-(chlorosulfonyl)-4-fluoro-;5-Carboxy-2-fluorobenzenesulphonyl chloride;2-fluoro-5-carboxybenzenesulphonyl chloride;3-(chlorosulfonyl)-4-fluorobenzoic acid(SALTDATA: FREE)
CBNumber
CB3196054
Molecular Formula
C7H4ClFO4S
Formula Weight
238.62
MOL File
2267-40-5.mol
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3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID Property

Melting point:
147-148℃
Boiling point:
388.6±27.0 °C(Predicted)
Density 
1.670±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder
pka
2.94±0.10(Predicted)
color 
White/off-white
InChI
InChI=1S/C7H4ClFO4S/c8-14(12,13)6-3-4(7(10)11)1-2-5(6)9/h1-3H,(H,10,11)
InChIKey
LZGZJLJZSAGDKR-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC=C(F)C(S(Cl)(=O)=O)=C1
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Safety

HS Code 
2916399090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS011580
Product name
3-chlorosulfonyl-4-fluoro-benzoic acid
Purity
Aldrich<SUP>CPR</SUP>
Packaging
100 mg
Price
$185
Updated
2025/07/31
TRC
Product number
C364488
Product name
3-(Chlorosulfonyl)-4-fluorobenzoicAcid
Packaging
2.5mg
Price
$45
Updated
2021/12/16
Oakwood
Product number
037319
Product name
3-Chlorosulfonyl-4-fluoro-benzoicacid
Purity
97%
Packaging
1g
Price
$14
Updated
2021/12/16
AK Scientific
Product number
J90122
Product name
3-Chlorosulfonyl-4-fluoro-benzoicacid
Packaging
5g
Price
$35
Updated
2021/12/16
Oakwood
Product number
037319
Product name
3-Chlorosulfonyl-4-fluoro-benzoicacid
Purity
97%
Packaging
5g
Price
$44
Updated
2021/12/16
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3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID Chemical Properties,Usage,Production

Synthesis

456-22-4

2267-40-5

Example 2: Synthesis of 2-fluoro-5-(4-methoxybenzoyl)-benzenesulfonamide; 4-fluorobenzoic acid (8 g, 57 mmol) was slowly added to chlorosulfonic acid (58 g, 498 mmol), followed by sodium chloride (10 g, 169 mmol). After the addition was completed, the reaction mixture was heated at 160°C for 5 hours. After completion of the reaction, the reaction mixture was cooled and slowly poured into ice water. The precipitated white solid precipitate was collected by filtration and redissolved in ethyl acetate. The organic layer was washed with saturated sodium chloride solution, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to remove the solvent. The residue was ground with hexane to give 7 g (51% yield) of the target product as a white solid.1H NMR (CDCl3): δ 8.78 (m, 1H), 8.52 (m, 1H), 7.5 (t, 1H).MS (m/z): 308 (M-1).

References

[1] Patent: US2004/2492, 2004, A1. Location in patent: Page/Page column 48-49
[2] Patent: WO2009/118292, 2009, A1. Location in patent: Page/Page column 42-43
[3] Journal of Medicinal Chemistry, 1997, vol. 40, # 13, p. 2017 - 2034
[4] Bioorganic and medicinal chemistry, 2002, vol. 10, # 3, p. 639 - 656
[5] Journal of Medicinal Chemistry, 2005, vol. 48, # 5, p. 1596 - 1609

3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID Suppliers

China 86 France 1 Germany 2 India 2 Switzerland 1 Ukraine 1 United Kingdom 3 United States 14 Global 110
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View Lastest Price from 3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
3-(chlorosulfonyl)-4-fluorobenzoic acid 2267-40-5
Price
US $0.00-0.00/KG
Min. Order
5mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-07
Career Henan Chemical Co
Product
3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID 2267-40-5
Price
US $1.00/KG
Min. Order
1KG
Purity
97-99%
Supply Ability
1000KGS
Release date
2019-12-18

2267-40-5, 3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACIDRelated Search:

Aluminum oxide 4-Nitrobenzenesulfonyl chloride Permethrin Loratadine 2-FLUORO-5-METHYLBENZENESULFONYL CHLORI& 2-CHLORO-5-CHLOROSULFONYL-4-FLUOROBENZO& 3-(Chlorosulfonyl)benzoic acid 2-Fluorobenzenesulfonyl chloride 2-bromo-5-(chlorosulfonyl)-4-fluorobenzoic acid 5-(chlorosulfonyl)-2,4-difluorobenzoic acid 3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID

  • Benzoic acid,3-(chlorosulfonyl)-4-fluoro-
  • 2-fluoro-5-carboxybenzenesulphonyl chloride
  • Benzoic acid,3-(chlo
  • 3-(chlorosulfonyl)-4-fluorobenzoic acid(SALTDATA: FREE)
  • 3-(Chlorosulphonyl)-4-fluorobenzoic acid
  • 5-Carboxy-2-fluorobenzenesulphonyl chloride
  • 3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID
  • 2267-40-5