ChemicalBook > CAS DataBase List > N-(4-butylphenyl)-4-fluorobenzenesulfonamide

N-(4-butylphenyl)-4-fluorobenzenesulfonamide

Product Name
N-(4-butylphenyl)-4-fluorobenzenesulfonamide
CAS No.
346692-04-4
Chemical Name
N-(4-butylphenyl)-4-fluorobenzenesulfonamide
Synonyms
DC260126;DC260126 >=98% (HPLC);DC260126;DC-260126 ;DC 260126;N-(4-butylphenyl)-4-fluorobenzenesulfonamide;Benzenesulfonamide, N-(4-butylphenyl)-4-fluoro-;stress,DC260126,DC-260126,FFAR,Inhibitor,insulin,inhibit,secretion,Apoptosis,DC 260126,Free Fatty Acid Receptor,phosphorylation,elevation,Ca2+
CBNumber
CB31968223
Molecular Formula
C16H18FNO2S
Formula Weight
307.38
MOL File
346692-04-4.mol
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N-(4-butylphenyl)-4-fluorobenzenesulfonamide Property

storage temp. 
-20°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1050
Product name
DC260126
Purity
≥98% (HPLC)
Packaging
5mg
Price
$92.2
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1050
Product name
DC260126
Purity
≥98% (HPLC)
Packaging
25mg
Price
$317
Updated
2022/05/15
Cayman Chemical
Product number
19388
Product name
DC260126
Purity
≥98%
Packaging
5mg
Price
$46
Updated
2024/03/01
Cayman Chemical
Product number
19388
Product name
DC260126
Purity
≥98%
Packaging
50 mg
Price
$276
Updated
2024/03/01
Cayman Chemical
Product number
19388
Product name
DC260126
Purity
≥98%
Packaging
1mg
Price
$28
Updated
2023/01/06
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N-(4-butylphenyl)-4-fluorobenzenesulfonamide Chemical Properties,Usage,Production

Description

DC260126 is a free fatty acid receptor 1 (FFAR1/GPR40) antagonist that inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic, oleic, palmitoleic, and lauric acid (Item Nos. 90150, 90260, 10009871, and 10006626, respectively) with IC50 values of 6.28, 5.96, 7.07, and 4.58 μM, respectively. At 10 mg/kg, it has been shown to inhibit glucose-stimulated insulin secretion, to reduce blood insulin levels, to improve insulin sensitivity, and to decrease the rate of pancreatic β-cell apoptosis in obese diabetic db/db mice.

storage

Store at -20°C

References

1) Hu?et al. (2009),?A novel class of antagonist for the FFAs receptor GPR40; Biochem. Biophys. Res. Commun.,?390?557 2) Zhang?et al. (2010),?DC260126, a small molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats; Biomed. Pharmacother.,?64?647 3) Sun?et al. (2013),?DC260126: a small molecule antagonist of GPR40 that protects against pancreatic β-cells dysfunction in db/db mice; PLoS One.,?8(6)?e66744 4) Wu?et al. (2012), Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis; J. Biochem,?113?1152

N-(4-butylphenyl)-4-fluorobenzenesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-butylphenyl)-4-fluorobenzenesulfonamide Suppliers

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346692-04-4, N-(4-butylphenyl)-4-fluorobenzenesulfonamideRelated Search:

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  • N-(4-butylphenyl)-4-fluorobenzenesulfonamide
  • DC260126
  • DC260126;DC-260126 ;DC 260126
  • Benzenesulfonamide, N-(4-butylphenyl)-4-fluoro-
  • DC260126 >=98% (HPLC)
  • stress,DC260126,DC-260126,FFAR,Inhibitor,insulin,inhibit,secretion,Apoptosis,DC 260126,Free Fatty Acid Receptor,phosphorylation,elevation,Ca2+
  • 346692-04-4