Boc-N-methyl-L-leucine

Product Name: Boc-N-methyl-L-leucine
CAS No.: 53363-89-6
Chemical Name: Boc-N-methyl-L-leucine
Synonyms: Tyr(Me);BOC-MELEU-OH;BOC-LEU(ME)-OH;BOC-L-MELEU-OH;BOC-ALA(TBU)-OH;BOC-N-ME-LEU-OH;BOC-N-ME-LEUCINE;Boc-N-Me-L-Leu-OH;BOC-BETA-TBU-ALA-OH;BOC-BETA-TBU-ALANINE
CBNumber: CB3197622
Molecular Formula: C12H23NO4
Formula Weight: 245.32
MOL File: 53363-89-6.mol

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Boc-N-methyl-L-leucine Property

Melting point:: 55-60 °C
Boiling point:: 338.2±21.0 °C(Predicted)
Density: 1.053±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
pka: 4.04±0.21(Predicted)
form: Solid
color: White to off-white
optical activity: [α]20/D 36±2°, c = 1% in methylene chloride
BRN: 2373250
InChI: InChI=1S/C12H23NO4/c1-8(2)7-9(10(14)15)13(6)11(16)17-12(3,4)5/h8-9H,7H2,1-6H3,(H,14,15)/t9-/m0/s1
InChIKey: YXJFAOXATCRIKU-VIFPVBQESA-N
SMILES: C(O)(=O)[C@H](CC(C)C)N(C(OC(C)(C)C)=O)C
CAS DataBase Reference: 53363-89-6(CAS DataBase Reference)

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Safety

WGK Germany: 3
HS Code: 2924 19 00
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.53083
Product name: Boc-N-Me-Leu-OH
Purity: Novabiochem?
Packaging: 5G
Price: $132
Updated: 2023/01/07

Sigma-Aldrich

Product number: 15446
Product name: Boc-N-Me-Leu-OH
Purity: ≥99.0% (sum of enantiomers, TLC)
Packaging: 5g
Price: $360
Updated: 2023/01/07

Usbiological

Product number: 264714
Product name: Boc-N-methyl-L-leucine
Packaging: 2g
Price: $333
Updated: 2021/12/16

Usbiological

Product number: 236540
Product name: Boc-N-methyl-L-leucine 98+%
Packaging: 1g
Price: $170
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB47462
Product name: Boc-N-methyl-L-leucine
Packaging: 25g
Price: $180
Updated: 2021/12/16

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Boc-N-methyl-L-leucine Chemical Properties,Usage,Production

Description

Boc-N-methyl-L-leucine is the BOC (tert-butyloxycarbonyl) protected N-methylated leucine. The N-methylated amino acid is quite useful in the peptide synthesis, giving a lot of improved properties to peptide. Studies have shown that peptide containing N-methylated amino acids obtain increased proteolytic stability, increased membrane permeability, and altered conformation. The effects of N-methylated amino acids are quite important in the development of therapeutic peptide compound as well as in the assay of biological activity of some modified peptides. BOC group can be easily removed by treatment with strong acids such as trifluoroacetic acid.

Uses

Boc-N-methyl-L-leucine, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Biological Activity

Boc-N-methyl-L-leucine is a peptidyl nucleobase that has been shown to inhibit tumor cell growth and induce tumor regression in animal models. It is an amide of leucine and the antibiotic aminouracil, which is a guanine analogue. Boc-N-methyl-L-leucine has also shown to inhibit tumor growth by inhibiting mitochondrial membrane potential, which may lead to cell death in cancer cells. This compound has been shown to be effective against both solid tumors and leukemia cell lines. Boc-N-methyl-L-leucine also inhibits the proliferation of human prostate cancer cells by blocking the synthesis of nucleic acids and proteins.

References

https://en.wikipedia.org/wiki/Tert-Butyloxycarbonyl_protecting_group
http://pubs.acs.org/doi/abs/10.1021/cr030024z?src=recsys&journalCode=chreay

Boc-N-methyl-L-leucine Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-N-methyl-L-leucine Suppliers

China 148 France 1 Germany 3 India 1 Japan 3 Switzerland 2 United Kingdom 4 United States 20 Global 182

ChemPep, Inc.

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View Lastest Price from Boc-N-methyl-L-leucine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-N-Me-L-Leu-OH 53363-89-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2023-09-27

Sichuan Jiaying Lai Technology Co.,LTD

Product: BOC-N-Me-leu-OH 53363-89-6
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2019-07-21

53363-89-6, Boc-N-methyl-L-leucineRelated Search:

L-Leucine N-CARBOBENZOXY-DL-LEUCINE Methylparaben Thiophanate-methyl BOC-L-Leucine Boc-Aib-OH L-tert-Leucine Bensulfuron methyl Methyl acrylate N-Carbobenzyloxyglycine Kresoxim-methyl Methyl BOC-GLY-LEU-OH FMOC-ARG(ME,PBF)-OH N-Boc-L-trans-4,5-Methanoproline BOC-D-ALLO-ILE-OH BOC-D-TYR(ET)-OH FMOC-CHA-OH

N-ALPHA-T-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE

N-ALPHA-T-BUTOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE

N-ALPHA-T-BUTOXYCARBONYL-BETA-T-BUTYL-L-ALANINE

N-ALPHA-T-BUTOXYCARBONYL-GAMMA-METHYL-L-LEUCINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE

N-ALPHA-T-BOC-N-ALPHA-METHYL-L-LEUCINE

BOC-BETA-TBU-ALANINE

BOC-BETA-TBU-ALA-OH

BOC-BETA-T-BUTYL-L-ALANINE

BOC-ALA(TBU)-OH

BOC-N-ME-LEUCINE

BOC-N-ME-LEU-OH

BOC-N-METHYL-L-LEUCINE

BOC-N-METHYL-L-LEU-OH

BOC-MELEU-OH

BOC-NEOPENTYLGLYCINE

BOC-(NEOPENTYL)GLY-OH

BOC-N-ALPHA-METHYL-L-LEUCINE

BOC-L-BETA-T-BUTYLALANINE

BOC-LEU(ME)-OH

BOC-L-NEOPENTYLGLYCINE

BOC-L-MELEU-OH

BOC-T-BUTYL-L-ALANINE

N-ALPHA-TERT-BUTYLOXYCABONYL-N-ALPHA-METHYL-L-LEUCINE

DANSYL-L-GLUTAMIC ACID BIS(CYCLOHEXYLAMMONIUM)

NALPHA-tert-Butoxycarbonyl-N-methyl-L-leucine

N-tert-Butyloxycarbonyl-N-methyl-L-leucine

N-(tert-butoxycarbonyl)-N-methyl-L-leucine

L-Leucine, N-[(1,1-diMethylethoxy)carbonyl]-N-Methyl-

(S)-2-((tert-butoxycarbonyl)(Methyl)aMino)-4-Methylpentanoic acid

Tyr(Me)

Boc-N-Me-L-Leu-OH

Boc-<I>N</I>-Me-Leu-OH

Boc-N-Methyl Leucine

Boc-N-methyl-L-leucine98+%

N-α-t-butoxycarbonyl-β-t-butyl-L-alanine

(Tert-Butoxy)Carbonyl N-Me-Leu-OH

(2S)-2-{[(tert-butoxy)carbonyl](methyl)amino}-4-methylpentanoic acid

(2S)-4-methyl-2-[methyl-[(2-methylpropan-2-yl)oxy-oxomethyl]amino]pentanoic acid

Boc-N-L-methylleucine

Boc-N-methyl-L-leucine USP/EP/BP

2-((TERT-BUTOXYCARBONYL)(METHYL)AMINO)-4-METHYLPENTANOIC ACID

N-[(1,1-Dimethylethoxy)carbonyl]-N-methyl-L-leucine

N-BOC-N-Methyl-L-leucine

BOC-N-methyl tert leucine

53363-89-6

Peptide Synthesis

N-Methyl Amino Acids

Unnatural Amino Acid Derivatives

Specialty Synthesis

amino acids

Amino Acid Derivatives

N-Methyl Amino Acids