2-AMINO-5-IODO-3-NITROPYRIDINE

Product Name: 2-AMINO-5-IODO-3-NITROPYRIDINE
CAS No.: 25391-57-5
Chemical Name: 2-AMINO-5-IODO-3-NITROPYRIDINE
Synonyms: Zinc04202918;5-iodo-3-nitro-2-pyridinamine;5-iodo-3-nitropyridin-2-aMine;2-PYRIDINAMINE,5-IODO-3-NITRO;2-Amino-3-nitro-5-iodopyridine;2-AMINO-5-IODO-3-NITROPYRIDINE;5-IODO-3-NITRO-PYRIDIN-2-YLAMINE;2-Amino-5-iodo-3-nitropyridine 95+%;2-AMINO-5-IODO-3-NITROPYRIDINE ISO 9001：2015 REACH
CBNumber: CB3203020
Molecular Formula: C5H4IN3O2
Formula Weight: 265.01
MOL File: 25391-57-5.mol

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2-AMINO-5-IODO-3-NITROPYRIDINE Property

Melting point:: 215-219 °C (lit.)
Boiling point:: 365.4±42.0 °C(Predicted)
Density: 2.229±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: solid
pka: 0.41±0.49(Predicted)
Appearance: Light yellow to yellow Solid
CAS DataBase Reference: 25391-57-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38-43
Safety Statements: 26-36/37
WGK Germany: 3
Hazard Note: Irritant
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A611350
Product name: 2-Amino-5-iodo-3-nitropyridine
Packaging: 5g
Price: $365
Updated: 2021/12/16

Usbiological

Product number: 415283
Product name: 2-Amino-5-iodo-3-nitropyridine
Packaging: 1g
Price: $403
Updated: 2021/12/16

TRC

Product number: A611350
Product name: 2-Amino-5-iodo-3-nitropyridine
Packaging: 25g
Price: $1450
Updated: 2021/12/16

AK Scientific

Product number: 2060AB
Product name: 5-Iodo-3-nitropyridin-2-amine
Packaging: 25g
Price: $344
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA46246
Product name: 2-Amino-5-iodo-3-nitropyridine
Packaging: 50g
Price: $820
Updated: 2021/12/16

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2-AMINO-5-IODO-3-NITROPYRIDINE Chemical Properties,Usage,Production

Uses

2-Amino-5-iodo-3-nitropyridine is used in the synthetic preparation of disubstituted pyridinyl azabicyclo heptanes as epibatidine analogs. These analogs are evaluated for its affinity for nicotinic acetylcholine receptors via in vitro and antinociceptive properties via in vivo in rats.

Synthesis

4214-75-9

25391-57-5

To a 250 mL three-necked flask were added 2-amino-3-nitropyridine (10.0 g, 72.0 mmol), acetic acid (44 mL) and water (10 mL). The mixture was heated to 90°C and then periodic acid (3.28 g, 14.4 mmol) and concentrated sulfuric acid (1.3 mL) at a mass percent concentration of 98% were added sequentially. After stirring for 10 min, iodine (9.1 g, 36.0 mmol) was added and stirring was continued for 60 min at this temperature. Upon completion of the reaction, the reaction solution was cooled to room temperature and subsequently poured into saturated aqueous sodium thiosulfate solution (100 mL). The solid product was separated by filtration and washed sequentially with saturated brine (50 mL x 2) and petroleum ether (50 mL x 2). The crude product was recrystallized using a mixed solvent of petroleum ether and ethyl acetate (5:1, v/v) to afford a high purity yellow solid 2-amino-5-iodo-3-nitropyridine (17.57 g, 69.1 mmol, 96% yield).

References

[1] Journal of Medicinal Chemistry, 2002, vol. 45, # 21, p. 4755 - 4761
[2] Patent: CN107325045, 2017, A. Location in patent: Paragraph 0006; 0009
[3] Patent: WO2013/53983, 2013, A1. Location in patent: Page/Page column 37
[4] Patent: US2015/11548, 2015, A1. Location in patent: Paragraph 0152

2-AMINO-5-IODO-3-NITROPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-5-IODO-3-NITROPYRIDINE Suppliers

China 86 India 3 Switzerland 1 Ukraine 1 United Kingdom 8 United States 18 Global 117

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View Lastest Price from 2-AMINO-5-IODO-3-NITROPYRIDINE manufacturers

Dideu Industries Group Limited

Product: 2-AMINO-5-IODO-3-NITROPYRIDINE 25391-57-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-07

Career Henan Chemical Co

Product: 2-AMINO-5-IODO-3-NITROPYRIDINE 25391-57-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kgs
Release date: 2020-01-29

25391-57-5, 2-AMINO-5-IODO-3-NITROPYRIDINERelated Search:

2-AMINO-3-IODO-5-NITROPYRIDINE 5-IODO-PYRIDIN-3-YLAMINE 2-amino-5-iodo-3-pyridinylamine 2-AMINO-5-IODO-3-NITROPYRIDINE

5-IODO-3-NITRO-PYRIDIN-2-YLAMINE

2-AMINO-5-IODO-3-NITROPYRIDINE

2-PYRIDINAMINE,5-IODO-3-NITRO

2-Amino-3-nitro-5-iodopyridine

Zinc04202918

5-iodo-3-nitropyridin-2-aMine

5-iodo-3-nitro-2-pyridinamine

2-Amino-5-iodo-3-nitropyridine 95+%

2-AMINO-5-IODO-3-NITROPYRIDINE ISO 9001：2015 REACH

25391-57-5

C5H4IN3O2

Halogenated Heterocycles

Pyridines

Heterocyclic Building Blocks

Building Blocks

Pyridines derivates

C5Heterocyclic Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyridines