ChemicalBook > CAS DataBase List > 4'-Hydroxy-3'-methoxypropiophenone

4'-Hydroxy-3'-methoxypropiophenone

Product Name: 4'-Hydroxy-3'-methoxypropiophenone
CAS No.: 1835-14-9
Chemical Name: 4'-Hydroxy-3'-methoxypropiophenone
Synonyms: Propioguaiacone;PROPIOVANILLONE;Eugenol Impurity 21;4-HYDROXY-3-METHOXYPROPIOPHENONE;3-METHOXY-4-HYDROXYPROPIOPHENONE;4'-hydroxy-3'-methoxypropiophenone;Propiophenone, 4'-hydroxy-3'-methoxy;1-(4-hydroxy-3-methoxyphenyl)-1-propanone;1-Propanone, 1-(4-hydroxy-3-methoxyphenyl)-;1-(4-HYDROXY-3-METHOXY-PHENYL)-PROPAN-1-ONE
CBNumber: CB3205110
Molecular Formula: C10H12O3
Formula Weight: 180.2
MOL File: 1835-14-9.mol

Less

4'-Hydroxy-3'-methoxypropiophenone Property

Melting point:: 61-62 °C
Boiling point:: 180-185 °C(Press: 15 Torr)
Density: 1.126±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 8.92±0.31(Predicted)
color: White to Dark Beige
LogP: 2.020 (est)
CAS DataBase Reference: 1835-14-9(CAS DataBase Reference)
NIST Chemistry Reference: 1-(4-hydroxy-3-methoxyphenyl)propanone(1835-14-9)
EPA Substance Registry System: 1-Propanone, 1-(4-hydroxy-3-methoxyphenyl)- (1835-14-9)

Less

Safety

Hazard Codes: T,N
Risk Statements: 25-51/53
Safety Statements: 45-61
HS Code: 2914500090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

TRC

Product number: H947600
Product name: 1-(4-Hydroxy-3-methoxyphenyl)-1-propanone
Packaging: 50mg
Price: $185
Updated: 2021/12/16

Matrix Scientific

Product number: 126754
Product name: 1-(4-Hydroxy-3-methoxyphenyl)propan-1-one
Purity: >95%
Packaging: 1g
Price: $252
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: APN0000263
Product name: 4-HYDROXY-3-METHOXYPROPIOPHENONE
Purity: 95.00%
Packaging: 1G
Price: $278.25
Updated: 2021/12/16

AK Scientific

Product number: Q284
Product name: 3-Methoxy-4-hydroxypropiophenone
Packaging: 250mg
Price: $118
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 95813
Product name: 1-(4-Hydroxy-3-methoxyphenyl)-1-propanone
Packaging: 10mg
Price: $450
Updated: 2021/12/16

Less

4'-Hydroxy-3'-methoxypropiophenone Chemical Properties,Usage,Production

Uses

1-(4-Hydroxy-3-methoxyphenyl)-1-propanone is a derivative of Guaiacol, a precursor to various flavorants, such as eugenol and vanillin.

Preparation

Preparation by Fries rearrangement of 2-methoxyphenyl propionate, (b.p.20 140–143°)
with aluminium chloride in nitrobenzene, first at 60–80° for 1 h, then at r.t. overnight, at 60° for 1 h or at 50° for 5 h (44%) ;
with aluminium chloride (2 mol) in nitromethane at r.t. for 24 h (65%)
with aluminium chloride in carbon disulfide
with titanium tetrachloride (2 mol) in nitromethane at r.t. for 24 h (62%)
with stannic chloride (2 mol) in nitromethane at r.t. for 24 h (69%)
with antimony pentachloride (2 mol) in nitromethane at r.t. for 24 h (28%) with formation of important tars.

Synthesis Reference(s)

The Journal of Organic Chemistry, 15, p. 227, 1950 DOI: 10.1021/jo01148a001

Synthesis

7598-60-9

1835-14-9

The general procedure for the synthesis of 3-methoxy-4-hydroxypropiophenone from (2-methoxyphenyl) propionate is as follows: powdered anhydrous aluminum chloride (3.0 g, 22.5 mmol) was dissolved in anhydrous nitrobenzene (10 mL) at 100 °C. After cooling to room temperature, 2-methoxyphenyl propionate (2.0 g, 11.1 mmol) was quickly added. The reaction mixture was heated at 60 °C for 1.5 h and subsequently cooled to room temperature. A 3N NaOH solution was added to the reaction mixture and stirred for 15 minutes. The suspension was filtered and the solid was washed with water. The filtrate was washed twice with dichloromethane (CH2Cl2) and then acidified with 3N HCl. The acidified aqueous phase was extracted with dichloromethane and the organic phases were combined. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography (eluent: petroleum ether/ethyl acetate = 10/1 to 5/1) to afford the target compound 3-methoxy-4-hydroxypropiophenone (874 mg, 44% yield) as a yellow oil.

References

[1] Patent: WO2013/97773, 2013, A1. Location in patent: Paragraph 0154
[2] Journal of the Chemical Society, 1930, p. 280,291
[3] Journal of the American Chemical Society, 1948, vol. 70, p. 60,62

4'-Hydroxy-3'-methoxypropiophenone Preparation Products And Raw materials

Raw materials

Preparation Products

Less

4'-Hydroxy-3'-methoxypropiophenone Suppliers

China 73 Germany 1 India 3 Ukraine 1 United Kingdom 8 United States 16 USA 1 Global 103

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Jinan Trio PharmaTech Co., Ltd.

Tel: 0531-88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com
Country: China
ProdList: 1856
Advantage: 62

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Quzhou Juhua Friendship Co., Ltd

Tel: 0570-3066667
Fax: 0570-3063388
Country: China
ProdList: 3930
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Tianjin Anhao Biological Technology Co., Ltd.

Tel
Email: sales@ahpharmatech.com
Country: China
ProdList: 5734
Advantage: 55

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

Changzhou Anxuan Chemical, Co., Ltd.

Tel: 13912302692 13912302692;
Fax: 0519-88064678
Email: sales@anxuanchem.com
Country: China
ProdList: 4828
Advantage: 58

DebyeTec.com Inc.

Tel: 18-086626237 18086626237
Fax: qq:2693528373
Email: 2693528373@qq.com
Country: China
ProdList: 2973
Advantage: 56

Wuhan Chemwish Technology Co.， Ltd

Tel: 027-67849912
Fax: 027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 9148
Advantage: 60

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

Aikon International Limited

Tel: 025-66061636 18013972705
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15814
Advantage: 58

Nanjing NingFan Pharm-Tech CO. LTD.

Tel: 17368696818
Country: China
ProdList: 1984
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

CD Chemical Group Limited

Tel: +8615986615575
Fax: 0086-13651442114
Email: info@codchem.com
Country: China
ProdList: 20342
Advantage: 58

Win-Win chemical CO., Limited

Tel: +86-0086-577-64498589 +86-15355981851
Fax: 0086-577-56994596
Email: sales@win-winchemical.com
Country: China
ProdList: 14359
Advantage: 58

Guangzhou Dreampharm Biotechnology Co., Ltd.

Tel: 020-36607679 19925672674
Fax: QQ 3008233717
Email: 3008233746@qq.com
Country: China
ProdList: 9883
Advantage: 12

SIMAGCHEM CORP

Tel: +86-5922680277 +86-13806087780
Email: sale@simagchem.com
Country: China
ProdList: 17346
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23912
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Country: China
ProdList: 39927
Advantage: 58

Wuhan Chemwish Technology Co., Ltd

Tel: 027-67849912
Email: sales@chemwish.com
Country: CHINA
ProdList: 10821
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

Fuxin Pharmaceutical

Tel: +86-021-021-50872116 +8613122107989
Email: contact@fuxinpharm.com
Country: China
ProdList: 10000
Advantage: 58

Chongqing Kemai Material Technology Co., Ltd

Tel: 17830741407
Fax: QQ：2479150351
Email: sales@chem47.com
Country: China
ProdList: 1768
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Mainchem Co., Ltd.

Tel: --
Fax: --
Email: sarah@mainchem.com
Country: China
ProdList: 6547
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-81124267 17392282731
Fax: 029-88380327
Email: 1073@dideu.com
Country: China
ProdList: 9992
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39665
Advantage: 58

Jiangsu Yaoheng Pharmaceutical Technology Co., Ltd.

Tel: 13524761129
Email: 2183470029@qq.com
Country: China
ProdList: 864
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29784
Advantage: 58

LGC Science (Shanghai) Ltd.

Tel: 17717235263
Email: cindy.yang@lgcgroup.com
Country: China
ProdList: 18003
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50751
Advantage: 58

Shanghai He-H Chemical Technology Co., Ltd

Tel: 18621911604
Email: 987025641@qq.com
Country: China
ProdList: 1063
Advantage: 58

Shanghai Tengjun Biotechnology Co. LTD

Tel: 19821570922
Email: angela@labgogo.com
Country: China
ProdList: 9896
Advantage: 58

Shanghai Jieshikai Biotechnology Co. , Ltd.

Tel: 021-57520305 13795461237
Email: zhuruyan@jskchem.com
Country: China
ProdList: 49234
Advantage: 58

BEIJINGYIWANJINGRUI

Tel: 15866847540
Email: dengyt2000@163.com
Country: China
ProdList: 4100
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Email: sales@coreychem.com
Country: China
ProdList: 29847
Advantage: 58

XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.

Tel: +8618950047208
Email: ellena@amitychem.com
Country: China
ProdList: 43416
Advantage: 58

HANGZHOU LEAP CHEM CO., LTD.

Tel: +86-571-87711850
Email: market18@leapchem.com
Country: China
ProdList: 43339
Advantage: 58

Hebei Chuanghai Biotechnology Co., Ltd

Tel: +8615531151365
Email: mina@chuanghaibio.com
Country: China
ProdList: 18126
Advantage: 58

GIHI CHEMICALS CO.,LIMITED

Tel: +8618058761490
Email: info@gihichemicals.com
Country: China
ProdList: 49934
Advantage: 58

Changzhou Anxuan Chemical Co., Ltd

Tel: +86-0519-89882563 +86-18961279162
Email: andy@anxuanchem.com
Country: China
ProdList: 4327
Advantage: 58

changzhou huayang technology co., ltd

Tel: +8615250961469
Email: 2571773637@qq.com
Country: China
ProdList: 9644
Advantage: 58

Aromsyn Co., Ltd.

Tel: +86-0571-85585865 +8613336024896
Email: CB@aromsyn.com
Country: China
ProdList: 19183
Advantage: 58

Qingdao HaiLinuo Chemical Co., Ltd.

Tel: --
Fax: --
Email: hailinuochem@163.com
Country: China
ProdList: 3894
Advantage: 55

Less

View Lastest Price from 4'-Hydroxy-3'-methoxypropiophenone manufacturers

Career Henan Chemical Co

Product: 4'-Hydroxy-3'-methoxypropiophenone 1835-14-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200kg
Release date: 2019-08-29

1835-14-9, 4'-Hydroxy-3'-methoxypropiophenoneRelated Search:

CHLOROPHOSPHONAZO III Citric acid monohydrate 1-Bromo-1-phenyl-2-propanone 2-CHLORO-3' 4'-DIMETHOXYBENZIL 97 CINOXACIN Ethyl 3,4,5-trimethoxybenzoylacetate CI 15511 Propiophenone 5,6-Dimethoxy-1-indanone 3′,4′-(Methylenedioxy)propiophenone 4',6,7-Trimethoxyisoflavone Glycitein Cryptopine 4-(3,4-DIMETHOXYPHENYL)-4-OXOBUTYRIC ACID Oxolinic acid Methoxypropiophenone 4'-Hydroxypropiophenone Protopine

3-METHOXY-4-HYDROXYPROPIOPHENONE

4-HYDROXY-3-METHOXYPROPIOPHENONE

PROPIOVANILLONE

1-(4-Hydroxy-3-methoxyphenyl)-1-propanone (propiovanillone)

Propioguaiacone

Propiophenone, 4'-hydroxy-3'-methoxy

1-(4-hydroxy-3-methoxyphenyl)-1-propanone

1-(4-HYDROXY-3-METHOXY-PHENYL)-PROPAN-1-ONE

Eugenol Impurity 21

1-Propanone, 1-(4-hydroxy-3-methoxyphenyl)-

4'-hydroxy-3'-methoxypropiophenone

1835-14-9

Aromatic Propiophenones (substituted)