4'-Hydroxy-3'-methoxypropiophenone Property

Melting point:

61-62 °C

Boiling point:

180-185 °C(Press: 15 Torr)

Density 

1.126±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

8.92±0.31(Predicted)

color 

White to Dark Beige

LogP

2.020 (est)

CAS DataBase Reference

1835-14-9(CAS DataBase Reference)

NIST Chemistry Reference

1-(4-hydroxy-3-methoxyphenyl)propanone(1835-14-9)

EPA Substance Registry System

1-Propanone, 1-(4-hydroxy-3-methoxyphenyl)- (1835-14-9)

Safety

Hazard Codes 

T,N

Risk Statements 

25-51/53

Safety Statements 

45-61

HS Code 

2914500090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

4'-Hydroxy-3'-methoxypropiophenone Chemical Properties,Usage,Production

Uses

1-(4-Hydroxy-3-methoxyphenyl)-1-propanone is a derivative of Guaiacol, a precursor to various flavorants, such as eugenol and vanillin.

Preparation

Preparation by Fries rearrangement of 2-methoxyphenyl propionate, (b.p.20 140–143°)
with aluminium chloride in nitrobenzene, first at 60–80° for 1 h, then at r.t. overnight, at 60° for 1 h or at 50° for 5 h (44%) ;
with aluminium chloride (2 mol) in nitromethane at r.t. for 24 h (65%)
with aluminium chloride in carbon disulfide
with titanium tetrachloride (2 mol) in nitromethane at r.t. for 24 h (62%)
with stannic chloride (2 mol) in nitromethane at r.t. for 24 h (69%)
with antimony pentachloride (2 mol) in nitromethane at r.t. for 24 h (28%) with formation of important tars.

Synthesis Reference(s)

The Journal of Organic Chemistry, 15, p. 227, 1950 DOI: 10.1021/jo01148a001