ChemicalBook > CAS DataBase List > 4'-(2-Methylpropyl)acetophenone

4'-(2-Methylpropyl)acetophenone

Product Name
4'-(2-Methylpropyl)acetophenone
CAS No.
38861-78-8
Chemical Name
4'-(2-Methylpropyl)acetophenone
Synonyms
1-(4-ISOBUTYLPHENYL)ETHAN-1-ONE;4-ISOBUTYLACETOPHENONE;1-(4-ISOBUTYLPHENYL)ETHANONE;4-IBAP;Nsc173015;1Y1&1R DV1;Ibuprofen-4;IBUPROFEN IMP E;p-Isobutylacetoph;TIMTEC-BB SBB007668
CBNumber
CB3210390
Molecular Formula
C12H16O
Formula Weight
176.25
MOL File
38861-78-8.mol
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4'-(2-Methylpropyl)acetophenone Property

Boiling point:
134-135°C 16mm
Density 
0,952 g/cm3
vapor pressure 
0.75Pa at 20℃
refractive index 
1.5180
Flash point:
54°C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
soluble in Dichloromethane; Diethyl Ether; Ethyl Acetate; THF
color 
Colorless to Yellow
Water Solubility 
Miscible with chloroform and methanol. Slightly miscible with water.
BRN 
1935275
InChI
InChI=1S/C12H16O/c1-9(2)8-11-4-6-12(7-5-11)10(3)13/h4-7,9H,8H2,1-3H3
InChIKey
KEAGRYYGYWZVPC-UHFFFAOYSA-N
SMILES
C(=O)(C1=CC=C(CC(C)C)C=C1)C
LogP
3.4 at 23℃
CAS DataBase Reference
38861-78-8(CAS DataBase Reference)
NIST Chemistry Reference
4'-(2-Methylpropyl)acetophenone(38861-78-8)
EPA Substance Registry System
Ethanone, 1-[4-(2-methylpropyl)phenyl]- (38861-78-8)
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Safety

Hazard Codes 
Xn,N,Xi
Risk Statements 
10-40-52/53-43
Safety Statements 
16-36-22-61-36/37
RIDADR 
1224
WGK Germany 
3
TSCA 
Yes
HazardClass 
3.2
PackingGroup 
III
HS Code 
29143990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1146
Product name
4′-Isobutylacetophenone
Packaging
500mg
Price
$128
Updated
2024/03/01
Sigma-Aldrich
Product number
BP557
Product name
4′-Isobutylacetophenone
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$222
Updated
2024/03/01
Sigma-Aldrich
Product number
1335541
Product name
Ibuprofen Related Compound C
Packaging
3x0.2ml
Price
$1380
Updated
2024/03/01
TCI Chemical
Product number
I0417
Product name
4'-Isobutylacetophenone
Purity
>96.0%(GC)
Packaging
25mL
Price
$72
Updated
2024/03/01
TCI Chemical
Product number
I0417
Product name
4'-Isobutylacetophenone
Purity
>96.0%(GC)
Packaging
100mL
Price
$197
Updated
2024/03/01
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4'-(2-Methylpropyl)acetophenone Chemical Properties,Usage,Production

Chemical Properties

Clear Colourless Oil

Uses

4'-isobutylacetophenone is an important starting material employed in the production of pharmaceuticals such as ibuprofen. It is also utilized in proteomics research. It is used as an intermediate in organic synthesis.

Uses

A degradation product of Ibuprofen in tablets, which is a known toxin. Ibuprofen (I140000) impuritiy.

Preparation

Synthesis of 4-isobutylacetophenone: toluene and propylene are reacted with the participation of metal potassium, sodium carbonate and graphite, Alkylation on methyl to generate isobutylbenzene, Then with acetyl chloride in the participation of anhydrous aluminum trichloride to obtain the product.

General Description

4'-(2-Methylpropyl)acetophenone, also known as Ibuprofen EP Impurity E, is an impurity of ibuprofen. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation.

4'-(2-Methylpropyl)acetophenone Preparation Products And Raw materials

Raw materials

Isobutylbenzene Aluminum chloride Potassium Graphite

Preparation Products

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4'-(2-Methylpropyl)acetophenone Suppliers

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View Lastest Price from 4'-(2-Methylpropyl)acetophenone manufacturers

Guangzhou Tosun Pharmaceutical Limited
Product
Ibuprofen EP Impurity E 38861-78-8
Price
US $0.00/mg
Min. Order
1mg
Purity
above 96%
Supply Ability
50kg
Release date
2023-05-09
Hebei Best Biological Technology Co., Ltd
Product
4'-(2-Methylpropyl)acetophenone 38861-78-8
Price
US $200.00/g
Min. Order
10g
Purity
99%
Supply Ability
1000t/month
Release date
2022-11-01
Hebei Mingeng Biotechnology Co., Ltd
Product
4'-(2-Methylpropyl)acetophenone 38861-78-8
Price
US $150.00/KG
Min. Order
1KG
Purity
99
Supply Ability
20tons
Release date
2021-06-07

38861-78-8, 4'-(2-Methylpropyl)acetophenoneRelated Search:

Ibuprofen 1-Hydroxyibuprofen (S)-(+)-Ibuprofen 1-Oxo Ibuprofen Ibuprofen Ethyl Ester 2-[4-(2-Methylpropyl)phenyl] ethanol 6-isobutyl-3-methyl-2,3-dihydro-1H-inden-1-one 2-(4-Methylphenyl)propanoic acid (2RS)-2-(4-BUTYLPHENYL)PROPANOIC ACID rac 2-Hydroxy Ibuprofen 4-(2-Methylpropyl)benzeneethanol (R)-(-)-IBUPROFEN Ibuprofen EP Impurity I 3-(4-ISOBUTYL-PHENYL)-PROPIONIC ACID p-Isobutylstyrene rac-Ibuprofen amide rac a-Hydroxy Ibuprofen (2RS)-2-(4-FORMYLPHENYL)PROPANOIC ACID Ibuprofen Impurity E

  • Imp. E:1-(4-isobutylphenyl)ethanone
  • TIMTEC-BB SBB007668
  • P-ISO-BUTYLACETOPHENONE
  • IBUPROFEN IMPURITY E
  • IBUPROFEN IMP E
  • ISOBUTYL ACETOPHENONE
  • 4'-Isobutylacetophenone, 97+%
  • 4'-ISOBUTYLACETOPHENONE
  • 4-ISOBUTYLACETOPHENONE
  • 1-[4-(2-METHYLPROPYL)PHENYL]ETHANONE
  • 1-(4-ISOBUTYLPHENYL)ETHAN-1-ONE
  • 1-(4-ISOBUTYLPHENYL)ETHANONE
  • 1-[4-(2-methylpropyl)phenyl]-ethanon
  • 4-Isobutylacetaphenone
  • 1-[4-(2-methylpropyl)phenyl]ethan-1-one
  • 1-(4-(2-METHYLPROPYL)PHENYL)ETNANONE
  • 4'-(2-Methylpropyl)acetophenone
  • 4-lsobutylacetophenone
  • Acetophenone, 4-isobutyl-
  • Ethanone, 1-[4-(2-methylpropyl)phenyl]-
  • Nsc173015
  • p-Isobutylacetoph
  • Ibuprofen IMpurity-E(EP)
  • 4'-(2-Methylpropyl)a
  • 1-[4-(2-Methylprop-1-yl)phenyl]ethan-1-one, 1-(4-Isobutylphenyl)ethan-1-one
  • Ibuprofen Related CoMpound C, USP
  • 3 ampules) (4-isobutylacetophenone)
  • 4-ISOBUTYLACETOPHENONE(Ibuprofen Related Compound C)(Ibuprofen Impurity E)
  • 1Y1&1R DV1
  • Ibuprofen-4
  • Ibuprofen Related Compound C (0.2 mL/ampule
  • 1-[4-(2-Methylpropyl)phenyl]-1-ethanone
  • 1-Acetyl-4-isobutylbenzene
  • p-Acetylisobutylbenzene
  • Ibuprofen EP Impurity E
  • 4-IBAP
  • Ibuprofen USP Related Compound C
  • Ibuprofen EP Impurity E：Ibuprofen Impurity E
  • 4'-Isobutylacetophenone&gt
  • 4-Isobutylacetophenone（Ibuprofen Impurity）
  • Ibuprofen Impurity 5（Ibuprofen EP Impurity E）
  • Ibuprofen Impurity E/4-isobutylacetophenone
  • Ibuprofen EP Impurity E/ Ibuprofen Related Compound C
  • Ibuprofen USP Related Compound CQ: What is Ibuprofen USP Related Compound C Q: What is the CAS Number of Ibuprofen USP Related Compound C Q: What is the storage condition of Ibuprofen USP Related Compound C Q: What are the applications of Ibuprofen USP Related Compound C
  • Ibuprofen EP Impurit
  • 4'-Isobutylacetophenone, ≥ 96.0%
  • 4’-Isobutylacetophenone
  • 4'-(2-Methylpropyl)acetophenone
  • 38861-78-8
  • Aromatic Acetophenones & Derivatives (substituted)
  • Aromatics, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
  • Aromatics
  • Impurities
  • Intermediates & Fine Chemicals
  • Pharmaceuticals