Environmental pollution carcinogenicity
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Octocrylene

Environmental pollution carcinogenicity
Product Name
Octocrylene
CAS No.
6197-30-4
Chemical Name
Octocrylene
Synonyms
UV-3039;octocrilene;PARSOL 340;2-ETHYLHEXYL 2-CYANO-3,3-DIPHENYLACRYLATE;Octocrilen;Mr Lin;LGB-OCT;Aokelilin;octocrylen;Octoctylene
CBNumber
CB3218114
Molecular Formula
C24H27NO2
Formula Weight
361.48
MOL File
6197-30-4.mol
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Octocrylene Property

Melting point:
-10 °C (lit.)
Boiling point:
218 °C/1.5 mmHg (lit.)
Density 
1.051 g/mL at 25 °C (lit.)
vapor pressure 
0Pa at 25℃
refractive index 
n20/D 1.567(lit.)
Flash point:
>230 °F
storage temp. 
15-25°C
solubility 
Chloroform (Slightly), Methanol (Sparingly)
form 
Oil
color 
Colourless to Light Yellow
Merck 
14,6756
InChIKey
FMJSMJQBSVNSBF-UHFFFAOYSA-N
LogP
6.1 at 23℃
CAS DataBase Reference
6197-30-4(CAS DataBase Reference)
EPA Substance Registry System
2-Ethylhexyl 2-cyano-3,3-diphenylacrylate (6197-30-4)
Absorption
uv max: 303 nm
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Safety

Risk Statements 
52
Safety Statements 
29/56
WGK Germany 
1
RTECS 
UD3328750
HS Code 
29269095
Toxicity
LD50 orl-rat: >5 g/kg NTIS** OTS0556792
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1477411
Product name
Octocrylene
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
02343
Product name
Octocrylene
Purity
analytical standard
Packaging
1ml
Price
$174
Updated
2024/03/01
TCI Chemical
Product number
C0968
Product name
2-Ethylhexyl 2-Cyano-3,3-diphenylacrylate
Purity
>98.0%(GC)
Packaging
25g
Price
$33
Updated
2024/03/01
TCI Chemical
Product number
C0968
Product name
2-Ethylhexyl 2-Cyano-3,3-diphenylacrylate
Purity
>98.0%(GC)
Packaging
100g
Price
$85
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1083
Product name
Octocrylene
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$94.3
Updated
2024/03/01
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Octocrylene Chemical Properties,Usage,Production

Environmental pollution

Octocrylene has been found in various environments, not least those of swimming pools, where it is evidently released by consumers to the point that it is now considered an emerging micropollutant similar to poly-fluoroalkyl substances (PFAS), blue-green algae, toxic fungal products, hormones, psychoactive drugs, pesticides, cosmetics, and industrial additives and drugs. These substances, unlike conventional and unconventional pollutants, are still largely unregulated by legislation and are not restricted by maximum permitted values. Furthermore, they are potentially dangerous for the environment and human health, even in an overall context of insufficient data linked to their dangerousness[1].

carcinogenicity

Octocrylene readily absorbs through the skin at levels about 14 times the FDA cutoff for systemic exposure. Octocrylene has been linked to aquatic toxicity, potentially harming coral health. The study suggests that octocrylene can break down to form a substance called benzophenone, which may lead to cancer. According to one study, benzophenone levels can increase in products over time. The European Commission recently concluded that although there was some evidence of octocrylene’s hormone-disrupting potential, current use concentrations of up to 10 percent were considered safe.

Description

Octocrylene (OCT) is a viscous, clear, colorlesss oi introduced in commercial sunscreens and anti-ageing creams about 15 years ago. It is the 2-ethylhexyl ester of 2-cyano-3,3-diphenylacrylic acid, with the extended conjugation of the acid portion that absorbs UVB and short-wave UVA (ultraviolet) rays, with wavelengths from 280 to 320 nm, which promote tanning but also contribute to the onset of sunburn and skin cancer. It is used in various body care products, in concentrations up to 10%, to provide an adequate sun-protection factor or to protect the body care formulations themselves from UV radiation[1].

Chemical Properties

Clear yellow viscous liquid with mild characteristic odor, Miscible in methanol, n-butanol, ethyl acetate, mineral oil, hexane, toluene. Immiscible in water. Octocrylene is an effective oil soluble liquid UV‐B filter. It has excellent dissolving properties for crystalline UV filters.

Uses

Octocrylene is an ingredient used in sunscreens for its ability to absorb UV rays, protecting the skin from sun damage. It is chemically related to cinnamates. It can be used to boost SPF and improve water resistance in a given formulation. Octocrylene is photostable and can improve the photostability of other sunscreens. It is expensive and can present difficulties in formulation.

Definition

ChEBI: Octocrylene is a diarylmethane. It is an ester formed by the condensation of a diphenylcyanoacrylate with 2-ethylhexanol, used in sunscreens and cosmetics.

Application

octocrylene is a uVB sunscreen with strong water-resistant properties and a rather broad-band absorption range. It exhibits good photostability, and is being evaluated by many companies as an effective SPF booster and waterproofing enhancer. This is an expensive ingredient with an approved usage level of 7 to 10 percent in both the united States and the european union. Although gaining in popularity among formulators, its cost and usage level can limit use. In addition, some studies are indicating it may cause allergic reactions in skin with a history of photoallergy.

benefits

Octocrylene is a compound often used as an additive in sun screen, and is thought to have skin moisturizing effects because of its emollient properties. What makes this chemical such a popular additive to sun block, is its ability to neutralize UV radiation dissipated by sunlight, and to minimize skin damage from prolonged sun exposure. Octocrylene protects the skin from the harmful effects of the sun and premature skin aging. It helps prevent the risk of skin cancer. This filter mainly absorbs UVB rays, and shorter UVA rays, which are responsible for aging but also for skin cancer.

General Description

Yellow viscous liquid. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Octocrilene is an ester derivative. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Fire Hazard

Flash point data for Octocrilene are not available. Octocrilene is probably combustible.

Flammability and Explosibility

Non flammable

Contact allergens

Octocrylene is an anti-UVB filter used in cosmetics that may induce photoallergic contact dermatitis.

Side effects

Some people are concerned about the body’s ability to absorb octocrylene, which can present in the blood, urine, and breast milk. It may promote the production of free radicals, which can damage DNA, potentially increasing the risk of melanoma. However, further research is necessary.
People with sensitive skin or skin conditions, such as eczema, may prefer to avoid products containing octocrylene. Alternatively, a person can perform a patch test before using a product containing octocrylene for the first time. The patch test should indicate if an individual is allergic or sensitive to an ingredient in the product.
The Food and Drug Administration (FDA) evaluated the safety of octocrylene for use in sunscreen products and found that concentrations of up to 10% are safe.
The European Scientific Committee on Consumer Safety (SCCS) also stated that octocrylene is safe in products containing concentrations of no more than 10%.
Berardesca, E.,et al.(2019). Review of the safety of octocrylene used as an ultraviolet filter in cosmetics.
https://onlinelibrary.wiley.com/doi/full/10.1111/jdv.15945

Safety Profile

Low toxicity by ingestion. Whenheated to decomposition it emits toxic vapors of NOx.

References

[1] Antonio Medici. “Octocrylene: From Sunscreens to the Degradation Pathway during Chlorination Processes: Formation of Byproducts and Their Ecotoxicity Assessment.” Molecules (2022).

Octocrylene Preparation Products And Raw materials

Raw materials

Preparation Products

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Octocrylene Suppliers

Suzhou Xiaoli Material Technology Co., Ltd.
Tel
0512-87815088 18015562287
Fax
0512-69233866
Email
xmwang@xiaolitech.com
Country
China
ProdList
68
Advantage
58
Changzhou Chemical Research Institute Co., Ltd.
Tel
0519-86649494 13656112367
Email
13656112367@139.com
Country
China
ProdList
1
Advantage
58
Qingdao Jiebaiao Auxiliaries Co. LTD
Tel
053268077006 17685522406
Email
tangyu@jadenmtc.com
Country
China
ProdList
327
Advantage
58
Jiangxi Lotchem Co., Ltd.
Tel
0791-0791-85061535 15270827708
Fax
0791-85061535
Email
lancetu@jxlotchem.com
Country
China
ProdList
311
Advantage
58
yxinchem
Tel
+86-0710-4323688 +86-18071785587
Fax
15502706050
Email
market@yxinchem.com
Country
China
ProdList
1022
Advantage
58
FUJIAN DISHENG TECHNOLOGY CO.,LTD.
Tel
0571-85890193 15869128402
Fax
0571-88226546
Email
hlf@shinyangchem.com
Country
China
ProdList
42
Advantage
58
Hubei Baoling Chemical Technology Co. , Ltd.
Tel
13129969326
Email
2797487194@qq.com
Country
China
ProdList
1007
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
Tianjin Zhongxin Chemtech Co., Ltd.
Tel
022-66880623
Fax
86(0)22-66880086
Email
sales@tjzxchem.com
Country
China
ProdList
613
Advantage
60
Wuhan EnTai Technology Development Co,.Ltd
Tel
86-27-82330560
Fax
86-27-82330547
Email
2536851935@qq.com
Country
China
ProdList
347
Advantage
69
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View Lastest Price from Octocrylene manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Octocrylene 6197-30-4
Price
US $0.00/Kg/Drum
Min. Order
200KG
Purity
95%-105%; USP
Supply Ability
20 tons
Release date
2021-07-12
Watson Biotechnology Co.,Ltd
Product
Octocrylene 6197-30-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20MT
Release date
2024-07-30
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Octocrylene 6197-30-4
Price
US $99.00-35.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-10

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