Environmental pollution carcinogenicity
ChemicalBook > CAS DataBase List > Octocrylene

Octocrylene

Environmental pollution carcinogenicity
Product Name
Octocrylene
CAS No.
6197-30-4
Chemical Name
Octocrylene
Synonyms
UV-3039;octocrilene;PARSOL 340;2-ETHYLHEXYL 2-CYANO-3,3-DIPHENYLACRYLATE;Octocrilen;Mr Lin;LGB-OCT;Aokelilin;octocrylen;Octoctylene
CBNumber
CB3218114
Molecular Formula
C24H27NO2
Formula Weight
361.48
MOL File
6197-30-4.mol
More
Less

Octocrylene Property

Melting point:
-10 °C (lit.)
Boiling point:
218 °C/1.5 mmHg (lit.)
Density 
1.051 g/mL at 25 °C (lit.)
vapor pressure 
0Pa at 25℃
refractive index 
n20/D 1.567(lit.)
Flash point:
>230 °F
storage temp. 
15-25°C
solubility 
Chloroform (Slightly), Methanol (Sparingly)
form 
Oil
color 
Colourless to Light Yellow
Merck 
14,6756
InChIKey
FMJSMJQBSVNSBF-UHFFFAOYSA-N
LogP
6.1 at 23℃
CAS DataBase Reference
6197-30-4(CAS DataBase Reference)
EPA Substance Registry System
2-Ethylhexyl 2-cyano-3,3-diphenylacrylate (6197-30-4)
Absorption
uv max: 303 nm
More
Less

Safety

Risk Statements 
52
Safety Statements 
29/56
WGK Germany 
1
RTECS 
UD3328750
HS Code 
29269095
Toxicity
LD50 orl-rat: >5 g/kg NTIS** OTS0556792
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1477411
Product name
Octocrylene
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
02343
Product name
Octocrylene
Purity
analytical standard
Packaging
1ml
Price
$174
Updated
2024/03/01
TCI Chemical
Product number
C0968
Product name
2-Ethylhexyl 2-Cyano-3,3-diphenylacrylate
Purity
>98.0%(GC)
Packaging
25g
Price
$33
Updated
2024/03/01
TCI Chemical
Product number
C0968
Product name
2-Ethylhexyl 2-Cyano-3,3-diphenylacrylate
Purity
>98.0%(GC)
Packaging
100g
Price
$85
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1083
Product name
Octocrylene
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$94.3
Updated
2024/03/01
More
Less

Octocrylene Chemical Properties,Usage,Production

Environmental pollution

Octocrylene has been found in various environments, not least those of swimming pools, where it is evidently released by consumers to the point that it is now considered an emerging micropollutant similar to poly-fluoroalkyl substances (PFAS), blue-green algae, toxic fungal products, hormones, psychoactive drugs, pesticides, cosmetics, and industrial additives and drugs. These substances, unlike conventional and unconventional pollutants, are still largely unregulated by legislation and are not restricted by maximum permitted values. Furthermore, they are potentially dangerous for the environment and human health, even in an overall context of insufficient data linked to their dangerousness[1].

carcinogenicity

Octocrylene readily absorbs through the skin at levels about 14 times the FDA cutoff for systemic exposure. Octocrylene has been linked to aquatic toxicity, potentially harming coral health. The study suggests that octocrylene can break down to form a substance called benzophenone, which may lead to cancer. According to one study, benzophenone levels can increase in products over time. The European Commission recently concluded that although there was some evidence of octocrylene’s hormone-disrupting potential, current use concentrations of up to 10 percent were considered safe.

Description

Octocrylene (OCT) is a viscous, clear, colorlesss oi introduced in commercial sunscreens and anti-ageing creams about 15 years ago. It is the 2-ethylhexyl ester of 2-cyano-3,3-diphenylacrylic acid, with the extended conjugation of the acid portion that absorbs UVB and short-wave UVA (ultraviolet) rays, with wavelengths from 280 to 320 nm, which promote tanning but also contribute to the onset of sunburn and skin cancer. It is used in various body care products, in concentrations up to 10%, to provide an adequate sun-protection factor or to protect the body care formulations themselves from UV radiation[1].

Chemical Properties

Clear yellow viscous liquid with mild characteristic odor, Miscible in methanol, n-butanol, ethyl acetate, mineral oil, hexane, toluene. Immiscible in water. Octocrylene is an effective oil soluble liquid UV‐B filter. It has excellent dissolving properties for crystalline UV filters.

Uses

Octocrylene is an ingredient used in sunscreens for its ability to absorb UV rays, protecting the skin from sun damage. It is chemically related to cinnamates. It can be used to boost SPF and improve water resistance in a given formulation. Octocrylene is photostable and can improve the photostability of other sunscreens. It is expensive and can present difficulties in formulation.

Definition

ChEBI: Octocrylene is a diarylmethane. It is an ester formed by the condensation of a diphenylcyanoacrylate with 2-ethylhexanol, used in sunscreens and cosmetics.

Application

octocrylene is a uVB sunscreen with strong water-resistant properties and a rather broad-band absorption range. It exhibits good photostability, and is being evaluated by many companies as an effective SPF booster and waterproofing enhancer. This is an expensive ingredient with an approved usage level of 7 to 10 percent in both the united States and the european union. Although gaining in popularity among formulators, its cost and usage level can limit use. In addition, some studies are indicating it may cause allergic reactions in skin with a history of photoallergy.

benefits

Octocrylene is a compound often used as an additive in sun screen, and is thought to have skin moisturizing effects because of its emollient properties. What makes this chemical such a popular additive to sun block, is its ability to neutralize UV radiation dissipated by sunlight, and to minimize skin damage from prolonged sun exposure. Octocrylene protects the skin from the harmful effects of the sun and premature skin aging. It helps prevent the risk of skin cancer. This filter mainly absorbs UVB rays, and shorter UVA rays, which are responsible for aging but also for skin cancer.

General Description

Yellow viscous liquid. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Octocrilene is an ester derivative. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Fire Hazard

Flash point data for Octocrilene are not available. Octocrilene is probably combustible.

Flammability and Explosibility

Non flammable

Contact allergens

Octocrylene is an anti-UVB filter used in cosmetics that may induce photoallergic contact dermatitis.

Side effects

Some people are concerned about the body’s ability to absorb octocrylene, which can present in the blood, urine, and breast milk. It may promote the production of free radicals, which can damage DNA, potentially increasing the risk of melanoma. However, further research is necessary.
People with sensitive skin or skin conditions, such as eczema, may prefer to avoid products containing octocrylene. Alternatively, a person can perform a patch test before using a product containing octocrylene for the first time. The patch test should indicate if an individual is allergic or sensitive to an ingredient in the product.
The Food and Drug Administration (FDA) evaluated the safety of octocrylene for use in sunscreen products and found that concentrations of up to 10% are safe.
The European Scientific Committee on Consumer Safety (SCCS) also stated that octocrylene is safe in products containing concentrations of no more than 10%.
Berardesca, E.,et al.(2019). Review of the safety of octocrylene used as an ultraviolet filter in cosmetics.
https://onlinelibrary.wiley.com/doi/full/10.1111/jdv.15945

Safety Profile

Low toxicity by ingestion. Whenheated to decomposition it emits toxic vapors of NOx.

References

[1] Antonio Medici. “Octocrylene: From Sunscreens to the Degradation Pathway during Chlorination Processes: Formation of Byproducts and Their Ecotoxicity Assessment.” Molecules (2022).

Octocrylene Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Octocrylene Suppliers

Americas 1 China 411 Europe 2 France 2 Germany 4 India 9 Japan 1 Slovakia 1 South Korea 1 Switzerland 1 United Kingdom 8 United States 43 Global 484
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Alfa Chemistry
Tel
1-516-6625404
Fax
1-516-927-0118
Email
support@alfa-chemistry.com
Country
United States
ProdList
9171
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
Alfa Chemistry
Tel
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
24072
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Protheragen-ING
Tel
+16313385890
Email
info@protheragen-ing.com
Country
United States
ProdList
3868
Advantage
58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19885
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Syrgis Performance Initiators, Inc.
Tel
--
Fax
--
Country
United States
ProdList
20
Advantage
50
Wilshire Chemical Company Inc.
Tel
--
Fax
--
Email
WilshrChem@AOL.COM
Country
United States
ProdList
3498
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Penta International Corporation
Tel
--
Fax
--
Email
lisaa@pentamfg.com
Country
United States
ProdList
5042
Advantage
58
Jiangyin Healthway International Trade Co., Ltd
Tel
--
Fax
--
Email
info@healthwaychem.com
Country
United States
ProdList
1006
Advantage
58
ECSA Chemicals
Tel
--
Fax
--
Email
marketing@ecsa.ch
Country
United States
ProdList
1735
Advantage
58
American International Chemical, Inc.
Tel
--
Fax
--
Email
info@aicma.com
Country
United States
ProdList
531
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Lycus Ltd.
Tel
--
Fax
--
Email
glenn.beeman@lycusltd.com
Country
United States
ProdList
9
Advantage
50
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
Penta Manufacturing Company
Tel
--
Fax
--
Email
sales@pentamfg.com
Country
United States
ProdList
5076
Advantage
65
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
DS Chemphy, Inc.
Tel
--
Fax
--
Country
United States
ProdList
205
Advantage
50
ChemService Inc.
Tel
--
Fax
--
Country
United States
ProdList
6379
Advantage
68
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Dastech International, Inc.
Tel
--
Fax
--
Email
info@dastech.com
Country
United States
ProdList
259
Advantage
51
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
BASF Corporation
Tel
--
Fax
--
Country
United States
ProdList
573
Advantage
86
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
Parchem Trading Ltd.
Tel
--
Fax
--
Email
info@parchem.com
Country
United States
ProdList
794
Advantage
76
Parchem Trading Ltd.
Tel
--
Fax
--
Email
info@par-chem.com
Country
United States
ProdList
740
Advantage
66
Pechiney
Tel
--
Fax
--
Email
chemicals@pechiney.com
Country
United States
ProdList
606
Advantage
55
Crescent Chemical Co., Inc.
Tel
--
Fax
--
Email
sales@creschem.com
Country
United States
ProdList
4597
Advantage
68
Biddle Sawyer Corporation
Tel
--
Fax
--
Email
bsc@biddlesawyer.com
Country
United States
ProdList
260
Advantage
58
More
Less

View Lastest Price from Octocrylene manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Octocrylene 6197-30-4
Price
US $100.00-70.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-16
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Octocrylene 6197-30-4
Price
US $99.00-35.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-10
Watson Biotechnology Co.,Ltd
Product
Octocrylene 6197-30-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20MT
Release date
2024-07-30

6197-30-4, OctocryleneRelated Search:

Biphenyl 2-Ethylhexyl acrylate tert-Butylchlorodiphenylsilane 6-Benzylaminopurine ISO-OCTYL METHACRYLATE Tris(trimethylsilyl)phosphate Methyl propiolate Methyl acrylate ISOOCTYL 3-MERCAPTOPROPIONATE ETHYL 2-CYANOACRYLATE BUTYL OLEATE 2-Chloro-3-cyanopyridine 2-Ethylhexyl mercaptoacetate 2-Isocyanatoethyl methacrylate Chlorodiphenylphosphine 2-Phenylbenzimidazole-5-sulfonic acid ETHYL 2-CYANO-3-METHYLCROTONATE ISOBUTYL TIGLATE

  • OCTYL 2-CYANO-3,3-DIPHENYLACRYLATE
  • octocrilene
  • OCTOCRYLENE
  • PARSOL 340
  • 2-cyano-3,3-diphenyl-2-propenoicaci2-ethylhexylester
  • 2-ethylhexylalpha-cyano-beta-phenylcinnamate
  • 2-Propenoicacid,2-cyano-3,3-diphenyl-,2-ethylhexylester
  • EUSOLEX OCR
  • 2-Ethyl-2-cyano-3,3-Diphenylacrylate
  • Octoctylene
  • 2-ETHYLHEXYL 2-CYANO-3,3-DIPHENYL-ACRYLATE 95%-105%
  • Octocrylene,2-Ethylhexyl-2Cyano-3,3-DiphenylAcrylate
  • 2-cyano-3,3-diphenyl-2-propanoic acid 2-ethylhexyl ester
  • 2-CYANO-3,3-DIPHENYLACRYLIC ACID 2-ETHYLHEXYL ESTER
  • 2-ETHYLHEXYL 2-CYANO-3,3-DIPHENYLACRYLATE
  • 2-ethylhexyl 2-cyano-3,3-diphenylpropenoate
  • Aokelilin
  • Parsol 340 (2-Ethylhexyl 2-Cyano-3,3-Diphenylacrylate)
  • OctocryleneUSP, 95.0-105.0% (Assay)
  • LGB-OCT
  • JADEWIN UV 3039
  • octocrylen
  • 2-ETHYLHEXYL-2-CYANO-3,3-DIPHENYL-2-PROPENOATE
  • 2-CYANO-3,3-DIPHENYL-2-PROPENOICACID2-ETHYLHEXYLESTER
  • Octocrilen
  • 2-Ethylhexyl-2-cyano-3,3-diphenylacrylate (OCTOCRYLENE)
  • OCTOCRYLENE USP
  • 3,3-Diphenyl-2-cyanoacrylic acid 2-ethylhexyl ester
  • Uvinul N-539
  • α-Cyano-β-phenylbenzeneacrylic acid 2-ethylhexyl ester
  • α-Cyano-β-phenylcinnamic acid 2-ethylhexyl ester
  • 3-Diphenyl-2-Cyanoacrylic Acid 2-Ethyl-
  • Octocrylene (500 mg)
  • 2-Cyano-3,3-diphenylacrylic Acid 2-Ethylhexyl Ester Octyl 2-Cyano-3,3-diphenylacrylate
  • ANTHELIOS SX ( octocrylene)
  • Ethylhexyl 2-cyano-3,3-diphenyl
  • UV-3039
  • 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate 97%
  • Parsol 340 0.2
  • UV Absorber 3039
  • 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate Solution, 100ppm
  • Mr Lin
  • 2-Ethylhexyl 2-Cyano-3,3-diphenylacrylate &gt
  • Octocrilene Solution in Methanol/THF/Water, 1000μg/mL
  • Octocrylene ISO 9001：2015 REACH
  • UV ABSORBER TRUELICHT UV 3039
  • Higenamin Hydrochloride
  • Octocrylene (1477411)
  • UV Filter Octocrylene
  • OCTOCRYLENE, UV-3039, 2-Ethylhexyl-2-Cyano-3,3-Diphenylacrylate
  • Sinosorb? UV-3039 / Octocrilene
  • UV absorber Octocrylene
  • Dsunpro Ocr
  • Octocrylene（Aokelilin）
  • OCTOCRYLENE -UV3039
  • 2-Ethylhexyl 2-cyano-3,3-diphenyl-2-propionate in methanol
  • C15894510 ParsoL340
  • Octocrylene 100 μg/ml Acetonitrile