ChemicalBook > CAS DataBase List > 2-[(1Z,2E)-1-Hydroxy-3-phenyl-2-propenylidene]-4-methoxy-4-cyclopentene-1,3-dione

2-[(1Z,2E)-1-Hydroxy-3-phenyl-2-propenylidene]-4-methoxy-4-cyclopentene-1,3-dione

Product Name: 2-[(1Z,2E)-1-Hydroxy-3-phenyl-2-propenylidene]-4-methoxy-4-cyclopentene-1,3-dione
CAS No.: 19956-53-7
Chemical Name: 2-[(1Z,2E)-1-Hydroxy-3-phenyl-2-propenylidene]-4-methoxy-4-cyclopentene-1,3-dione
Synonyms: Lucidone;2-[(1Z,2E)-1-Hydroxy-3-phenyl-2-propenylidene]-4-methoxy-4-cyclopentene-1,3-dione;(2E)-2-[(2E)-1-Hydroxy-3-phenyl-2-propen-1-ylidene]-4-methoxy-4-cyclopentene-1,3-dione;4-Cyclopentene-1,3-dione,2-[(2E)-1-hydroxy-3-phenyl-2-propenylidene]-4-methoxy-, (2Z)-
CBNumber: CB32214156
Molecular Formula: C15H12O4
Formula Weight: 256.25
MOL File: 19956-53-7.mol

Less

2-[(1Z,2E)-1-Hydroxy-3-phenyl-2-propenylidene]-4-methoxy-4-cyclopentene-1,3-dione Property

Melting point:: 166.5-168.5 °C
Boiling point:: 489.6±45.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
pka: 4.50±1.00(Predicted)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

Less

N-Bromosuccinimide Price

Arctom

Product number: AS148600
Product name: Lucidone
Purity: ≥98%
Packaging: 5mg
Price: $226
Updated: 2021/12/16

Arctom

Product number: CFN98011
Product name: Lucidone
Packaging: 5mg
Price: $373
Updated: 2021/12/16

Crysdot

Product number: CD32002081
Product name: Lucidone
Purity: 95+%
Packaging: 5mg
Price: $590
Updated: 2021/12/16

Less

2-[(1Z,2E)-1-Hydroxy-3-phenyl-2-propenylidene]-4-methoxy-4-cyclopentene-1,3-dione Chemical Properties,Usage,Production

Uses

Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE2 production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents NF-κB translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC50=25 μM)[1][2].

Definition

ChEBI: Lucidone is an olefinic compound. It is functionally related to a cinnamic acid.

in vivo

Lucidone (1 mg/kg; intracranial injection; 3 times for 1 week) significantly increases the survival rate and body weight of DENV-infected mice^[2].

Animal Model:	DENV-infected ICR mice^[2]
Dosage:	0.4 mg/kg, 1 mg/kg
Administration:	Intracranial injection; 3 times dose at day 2, 4, 6 after DENV infection
Result:	Increased the survival rate and body weight of DENV-infected mice on day 7.

IC 50

p38 MAPK; JNK; p50; p65; COX-2; NF-κB; iNOS; IKK

References

[1] Senthil Kumar KJ, et aL. Lucidone inhibits iNOS and COX-2 expression in LPS-induced RAW 264.7 murine macrophage cells via NF-kappaB and MAPKs signaling pathways. Planta Med. 2009 Apr;75(5):494-500. DOI:10.1055/s-0029-1185309
[2] Chen WC, et al. Lucidone suppresses dengue viral replication through the induction of heme oxygenase-1. Virulence. 2018 Jan 1;9(1):588-603. DOI:10.1080/21505594.2017.1421893

2-[(1Z,2E)-1-Hydroxy-3-phenyl-2-propenylidene]-4-methoxy-4-cyclopentene-1,3-dione Preparation Products And Raw materials

Raw materials

Preparation Products

Less

2-[(1Z,2E)-1-Hydroxy-3-phenyl-2-propenylidene]-4-methoxy-4-cyclopentene-1,3-dione Suppliers

China 47 United States 5 Global 52

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5645
Advantage: 65

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Fax: 021-55068248
Email: 3423497944@qq.com
Country: China
ProdList: 8144
Advantage: 55

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 6905
Advantage: 55

Chengdu DingDang Pharmaceutical Co., Ltd.

Tel: 028-86040038 13980902949;
Fax: 028-85149890
Email: market@dingdangchem.com
Country: China
ProdList: 1853
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai ChengShao Biological Technology Co., Ltd.

Tel: 021-61847300 13341622919
Fax: 021-61847300
Email: shcss01@163.com
Country: China
ProdList: 4808
Advantage: 58

Chengdu Push Bio-Technology Co., Ltd.

Tel: 028-028-85370565-229-229 18080489829
Email: 18080489829@163.com
Country: China
ProdList: 8250
Advantage: 60

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Jiangsu aikang biomedical research and development co., LTD

Tel: 025-58859352 13155353615
Email: qzhang@aikonchem.com
Country: China
ProdList: 15525
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28172
Advantage: 58

Zhejiang Lianshuo Biotechnology Co., Ltd.

Tel: 18616526224
Email: lianshuo@vip.126.com
Country: China
ProdList: 9607
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 18438616290
Email: lanwu@univ-bio.com
Country: China
ProdList: 24731
Advantage: 58

Shanghai Fusheng Industrial Co., LTD

Tel: 021-52961053 13524666654
Email: 3004902811@qq.com
Country: China
ProdList: 9724
Advantage: 58

Wuxi Helen Biotechnology Co., Ltd.,

Tel: 0510-85629785 18013409632
Fax: 0510-85625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 14081
Advantage: 58

Shanghai Hewu Biotechnology Co., LTD

Tel: 021-57886085 17317861055
Email: shhebio@126.com
Country: CHINA
ProdList: 7974
Advantage: 58

Foshan Treasure Biotechnology Co., Ltd

Tel: 0757-85921206 18520245316
Email: 2329783215@qq.com
Country: China
ProdList: 12661
Advantage: 58

Beijing PUXI Technology Co., Ltd

Tel: 400-8087372 13161114455
Email: puxi_sale@qq.com
Country: China
ProdList: 4990
Advantage: 58

Shanghai Moqi Biological Technology Co., LTD

Tel: 021-38218169 13681877033
Email: 2702713455@qq.com
Country: China
ProdList: 9997
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Naturewill Biotechnology Co., Ltd.

Tel: 028-82632533 18113192475
Email: 3157321941@qq.com
Country: China
ProdList: 4993
Advantage: 58

Sichuan BioCrick Biotech Co., Ltd

Tel: 28-86-28-8543-3893 13260669172
Email: sales@biocrick.com
Country: China
ProdList: 5020
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Biorbyt Ltd.

Tel: --
Fax: --
Email: info@biorbyt.com
Country: CHINA
ProdList: 6482
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

BioBioPha Co., Ltd.

Tel: --
Fax: --
Email: sales@mail.biobiopha.com
Country: CHINA
ProdList: 6453
Advantage: 58

Shanghai Guduo Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6688
Advantage: 58

Shanghai Yuanmu Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6412
Advantage: 58

Shanghai Ruichu Biotechnology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6969
Advantage: 58

Shanghai Yanjin Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: yanjinbio@163.com
Country: CHINA
ProdList: 6896
Advantage: 58

Shanghai Qiaoyu Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6890
Advantage: 58

Wuhan Qiongge Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 1214415300@qq.com
Country: CHINA
ProdList: 5475
Advantage: 58

Beijing Huayueyang Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 1365647552@qq.com
Country: CHINA
ProdList: 3655
Advantage: 58

Shanghai Wowu Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shhebio@126.com
Country: CHINA
ProdList: 6137
Advantage: 58

Shanghai Lianmai Biological Engineering Co., Ltd.

Tel: --
Fax: --
Email: shlmai@163.com
Country: CHINA
ProdList: 6055
Advantage: 58

Shanghai yiji industries Co., Ltd.

Tel: --
Fax: --
Email: yiji01@foxmail.com
Country: China
ProdList: 6021
Advantage: 50

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Shanghai Zeye Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: shzeysw@163.com
Country: CHINA
ProdList: 6548
Advantage: 58

Shanghai Machine Pure Industrial Co., Ltd.

Tel: --
Fax: --
Email: 3245176082@qq.com
Country: CHINA
ProdList: 6800
Advantage: 58

Xiamen Research Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1562893815@qq.com
Country: CHINA
ProdList: 6936
Advantage: 58

Suzhou Ruinuode Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 2090855807@qq.com
Country: CHINA
ProdList: 6249
Advantage: 58

Xiamen Huijia Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6973
Advantage: 58

Shanghai Gaochuang Chemical Technology Co., Ltd.

Tel: --
Fax: --
Email: gaochem@163.com
Country: CHINA
ProdList: 6995
Advantage: 58

Shanghai Yanmu Industrial Co., Ltd.

Tel: --
Fax: --
Email: 2095001174@qq.com
Country: CHINA
ProdList: 6722
Advantage: 58

19956-53-7, 2-[(1Z,2E)-1-Hydroxy-3-phenyl-2-propenylidene]-4-methoxy-4-cyclopentene-1,3-dioneRelated Search:

Methyllucidone Linderone Ethyllucidone Calyxin B 2',4'-Dihydroxy-2,3',6'-trimethoxychalcone methyllinderone helichrysetin ROBTEIN 2'-HYDROXY-3,4,5,6'-TETRAMETHOXYCHALCONE Pashanone 2'-O-Methylisoliquiritigenin 2',4'-Dihydroxy-3',6'-dimethoxychalcone Silibinin SOYASAPOGENOL B(P) Syringic acid Dihydromyricetin VERBENALIN syringaresinol

2-[(1Z,2E)-1-Hydroxy-3-phenyl-2-propenylidene]-4-methoxy-4-cyclopentene-1,3-dione

Lucidone

4-Cyclopentene-1,3-dione,2-[(2E)-1-hydroxy-3-phenyl-2-propenylidene]-4-methoxy-, (2Z)-

(2E)-2-[(2E)-1-Hydroxy-3-phenyl-2-propen-1-ylidene]-4-methoxy-4-cyclopentene-1,3-dione

19956-53-7