Atropic acid

Product Name: Atropic acid
CAS No.: 492-38-6
Chemical Name: Atropic acid
Synonyms: NSC 20987;ATROPIC ACID;Atropic Acid >10029 ATROPIC ACID;2-PHENYLACRYLIC ACID;Cinacalcet ImpurityI;Α-PHENYLACRYLIC ACID;Atropic acid，492-38-6;2-Phenylpropenoic acid;Ipratropium Impurity D
CBNumber: CB3224700
Molecular Formula: C9H8O2
Formula Weight: 148.16
MOL File: 492-38-6.mol

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Atropic acid Property

Melting point:: 106-107°
Boiling point:: bp ~267° with partial decompn
Density: 1.0061 (rough estimate)
refractive index: 1.5049 (estimate)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.86±0.11(Predicted)
color: White to Off-White
Water Solubility: 1.3g/L(20 ºC)
Merck: 14,874
Stability:: Light Sensitive
InChIKey: ONPJWQSDZCGSQM-UHFFFAOYSA-N
CAS DataBase Reference: 492-38-6(CAS DataBase Reference)
NIST Chemistry Reference: Benzeneacetic acid, «alpha»-methylene-(492-38-6)
EPA Substance Registry System: Benzeneacetic acid, .alpha.-methylene- (492-38-6)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2390
Product name: Atropic Acid
Purity: >93.0%(GC)
Packaging: 5g
Price: $55
Updated: 2024/03/01

TCI Chemical

Product number: A2390
Product name: Atropic Acid
Purity: >93.0%(GC)
Packaging: 25g
Price: $189
Updated: 2024/03/01

TRC

Product number: A793850
Product name: Atropic Acid
Packaging: 100mg
Price: $65
Updated: 2021/12/16

TRC

Product number: A793850
Product name: Atropic Acid
Packaging: 250mg
Price: $80
Updated: 2021/12/16

TRC

Product number: A793850
Product name: Atropic Acid
Packaging: 1g
Price: $105
Updated: 2021/12/16

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Atropic acid Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid.

Uses

Atropic acid is an Impurity of Ipratropium bromide and Atropine Sulfate. Atropic acid and β,β-dimethylatropic acid are plant growth regulators.

Preparation

The synthesis of atropic acid involves several steps. Firstly, tropic acid is oxidized with hot KMnO4 to form benzoic acid. Secondly, tropic acid reacted with HBr to produce C9H9O2Br. Thirdly, C9H9O2Br is reacted with alcoholic KOH to yield atropic acid, C9H8O2. Finally, atropic acid is catalytically hydrogenated to form hydratropic acid, C9H10O2.

Reactions

Atropic acid is formed by the dehydration of tropic acid. Hence addition of water to atropic acid gives tropic acid.
Atropic acid, on oxidation yields benzoic acid. The formation of benzoic acid reveals that atropic acid and tropic acid contain atleast one benzene nucleus with a side chain containing carboxylic acid in their structure.

As atropic acid is an unsaturated acid it mean atropic acid may be either structure (I) or (II) .
Hence, the structure (II) is atropic acid which is confirmed by oxidation with KMnO4 to form phenylglyoxal.

Atropic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Atropic acid Suppliers

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View Lastest Price from Atropic acid manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Atropic acid 492-38-6
Price: US $1.00-100.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 200000KG
Release date: 2024-07-16

Wuhan Boyuan Import & Export Co., LTD

Product: 2-Phenylacrylic acid 492-38-6
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000tons
Release date: 2023-05-25

Guangzhou Tosun Pharmaceutical Limited

Product: Ipratropium Bromide EP Impurity D 492-38-6
Price: US $0.00/mg
Min. Order: 1mg
Purity: above 96%
Supply Ability: 50mg
Release date: 2023-05-22

492-38-6, Atropic acidRelated Search:

Poly(acrylic acid) Hyaluronic acid Butyl acrylate 1-Phenyl-2-nitropropene Acrylic acid Ethyl acrylate Methacrylic acid Folic acid Methyl acrylate Methyl methacrylate 6-Benzylaminopurine Ethyl 2-(Chlorosulfonyl)acetate Citric acid Atovaquone trans-Cinnamic acid Ipratropium bromide monohydrate IpratropiuM BroMide IMpurity E Ipratropium Bromide Impurity 1

2-Phenylpropenoic acid

2-PHENYLPROP-2-ENOIC ACID

Ipratropium EP Impurity D

Ipratropium Bromide EP Impurity D (2-Phenyl Acrylic Acid)

Ipratropium Bromide EP Impurity D

2-Phenylacrylic acid 95%

2-PHENYLACRYLIC ACID

ALPHA-PHENYLACRYLIC ACID

alpha-Phenylacrylic acid 2-Phenylacrylic acid 2-Phenylprop-2-enoic acid

ATROPIC ACID

2-Propenoic acid, 2-phenyl-

Acrylic acid, 2-phenyl-

alpha-Toluic acid, alpha-methylene-

Benzeneacetic acide, alpha-methylene-

Propenoic acid, 2-phenyl-

α-methylene-α-toluic acid

ATROPIC ACID / 2-PHENYLACRYLIC ACID

10029 ATROPIC ACID

α-Methylenebenzeneacetic acid

2-Phenylprop-2-enoic acid, Atropic acid

2-Phenyl-2-propenoic Acid

NSC 20987

Benzeneacetic acid, a-Methylene-

Benzeneacetic acid, .alpha.-methylene-

Ipratropium Bromide Impurity 4(Ipratropium EP Impurity D)

Ipratropium bromide Impurity D

Cinacalcet ImpurityI

Ipratropium Impurity D

Atropic Acid( Alpha-Phenylacrylic Acid )

Atropic Acid &gt

2-Phenylacrylic acid, 97%, for synthesis

Benzeneacetic acid, α-methylene-

Ipratropium Bromide Impurity 4（Ipratropium Bromide EP Impurity D）

Α-PHENYLACRYLIC ACID

Atropic acid，492-38-6

Benzeneacetic acid, α-methylene-

492-38-6

C9H8O2

CH2CC6H5COOH

Aromatics, Impurities

Pharmaceutical Intermediates