2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride

Product Name: 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride
CAS No.: 86604-75-3
Chemical Name: 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride
Synonyms: 2-(CHLOROMETHYL)-4-METHOXY-3,5-DIMETHYLPYRIDINE HYDROCHLORIDE;Omeprazole chloride;2-CHLORO METHYL-3,5-DIMETHLY-4-METHOXY PYRIDINE HCL;CMDM;TENA-006;Esomeprazole INT;Omeprazole Chloro;86604-75-3C9H13CL2NO;2-Chloromethyl-4-met;Omeprazole Impurity 9
CBNumber: CB3226946
Molecular Formula: C9H13Cl2NO
Formula Weight: 222.11
MOL File: 86604-75-3.mol

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2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride Property

Melting point:: 128-131 °C(lit.)
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), Methanol (Sparingly)
form: Solid
color: White to Off-White
Water Solubility: Soluble in water.
InChI: InChI=1S/C9H12ClNO.ClH/c1-6-5-11-8(4-10)7(2)9(6)12-3;/h5H,4H2,1-3H3;1H
InChIKey: LCJDHJOUOJSJGS-UHFFFAOYSA-N
SMILES: C1(CCl)=NC=C(C)C(OC)=C1C.[H]Cl
CAS DataBase Reference: 86604-75-3(CAS DataBase Reference)

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Safety

Risk Statements: 34
Safety Statements: 26-36/37/39-45
RIDADR: 3261
WGK Germany: 3
HazardClass: 8
PackingGroup: II
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 535508
Product name: 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride
Purity: 98%
Packaging: 5g
Price: $26.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 535508
Product name: 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride
Purity: 98%
Packaging: 25g
Price: $37.5
Updated: 2025/07/31

TCI Chemical

Product number: C2269
Product name: 2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: C2269
Product name: 2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $89
Updated: 2025/07/31

TRC

Product number: C369240
Product name: 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride
Packaging: 50g
Price: $255
Updated: 2021/12/16

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2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride is used as pharmaceutical intermediates. It is an intermediate in the production of the antiulcer agent Omeprazole.

Synthesis

86604-78-6

86604-75-3

The general procedure for the synthesis of 2-chloromethyl-3,5-dimethyl-4-methoxypyridine hydrochloride from 4-methoxy-3,5-dimethyl-2-hydroxymethylpyridine was as follows: to a solution of 4-methoxy-3,5-dimethyl-2-hydroxymethylpyridine (25.1 g, 0.15 mol) in dichloromethane (400 mL) was added slowly and dropwise thionyl chloride (18.8 g, 0.158 mol) in dichloromethane (100 mL). 0.158 mol) to a solution of thionyl chloride (18.8 g, 0.158 mol) in dichloromethane (100 mL). The reaction was carried out at room temperature and under argon protection, and the titration process lasted for 30 minutes. After the dropwise addition, the reaction was continued with stirring at room temperature for 30 minutes. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The solid residue obtained was suspended in hexane (200 mL) and the solid was collected by filtration. The solid was washed with hexane (50 mL) and subsequently dried in air to afford 2-chloromethyl-3,5-dimethyl-4-methoxypyridine hydrochloride 33.3 g (100% yield) as a white solid.

References

[1] Patent: WO2004/9583, 2004, A2. Location in patent: Page 156
[2] Patent: US2005/38076, 2005, A1. Location in patent: Page/Page column 6
[3] Patent: CN107011252, 2017, A. Location in patent: Paragraph 0063; 0064; 0066; 0068; 0072; 0074
[4] Journal of Medicinal Chemistry, 1998, vol. 41, # 11, p. 1777 - 1788
[5] Patent: US5292886, 1994, A

2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride Preparation Products And Raw materials

Raw materials

2,3,5-Collidine

Preparation Products

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2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride Suppliers

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View Lastest Price from 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride 86604-75-3
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 10 tons
Release date: 2021-08-09

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride 86604-75-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-31

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride 86604-75-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-17

86604-75-3, 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochlorideRelated Search:

2-Pyridylacetic acid hydrochloride N,N-Dimethylformamide Pyridine hydrochloride 4-Methoxypyridine 4-Pyridineacetic acid hydrochloride 2-Chloro-6-methoxypyridine 2-(Chloromethyl)pyridine hydrochloride 2,6-Lutidine Topotecan hydrochloride Poly(dimethylsiloxane) 3-Pyridylacetic acid hydrochloride DIMETHYLAMINOPYRIDINE, POLYMER-BOUND 3-Picolyl chloride hydrochloride Dimethyl sulfoxide 4-(Chloromethyl)pyridine hydrochloride 2-Methoxyethanol N,N-Dimethylacetamide 4-Desmethoxy-4-nitro Omeprazole Sulfide

CMDM

Omeprazole intermediate

Omeprazole EP Impurity XI

2-(chloromethyl)-4-methoxy-3,5-dimethyl-pyridine dyhydrochloride

Omeprazole chloride

2-chloro-methyl-3,5-dimethyl-4-methoxy pyridine hcl (omeprazole-chloro compound)

Omeprazole Related Compound 13

Omeprazole Impurity W

Omeprazole Impurity 9

Omeprazole Related Compound 13 HCl

TENA-006

86604-75-3C9H13CL2NO

2-CHLOROMETHYL-3,5-DIMETHYL-4-METHOXYPYRIDINE HCL

2-CHLOROMETHYL-3,5-DIMETHYL-4-METHOXYPYRIDINE HYDROCHLORIDE

2-CHLOROMETHYL-4-METHOXY-3,5-DIMETHYL PYRIDINE HCL

2-(CHLOROMETHYL)-4-METHOXY-3,5-DIMETHYLPYRIDINE HYDROCHLORIDE

2-(CHLOROMETHYL)-4-METHOXY-3,5-LUTIDINE HCL

2-CHLOROMETHYL-4-METHOXY-3,5-LUTIDINE HYDROCHLORIDE

3,5-Dimethyl-2-chloromethyl-4-methoxypyridine hydrochloride

Esomeprazole Sodium Impurity 42

2-Chloromethyl-3,5-dimethyl

Pyridine,2-(chloromethyl)-4-methoxy-3,5-dimethyl

2-(CHLOROMETHYL)-4-METHOXY-3,5-DIMETHYL-PYRIDINEHYDROCHLORIDE(INTERMEDIATEOFOMEPRAXOLE)

2-(CHLOROMETHYL)-4-METHOXY-3,5-DIMETHYL-PYRIDINE HDYROCHLORIDE

2-CHLOROMETHYL-4-METHOXY-3,5-DIMETHYLPYRIDINE HCLOMEPRAZOLE

2-Chloromethyl-4-met

(S)-Omeprazole Intermediate 1

2-ChloroMethyl-4-Methoxy-3,5-diMethylpyridine hydrochloride 98%

2-ChloroMethyl-3,5-diMethyl-4-Methoxy pyridine hydrochlorid

Omeprazole chloride compound

2-Chloromethyl-4-methoxy-3,5-dimethylpyridinehydrochloride,98%

2-ChloroMethyl-4-Methoxy-3,5-diMethylpyridine hydr

OMeprazole chloro interMediate

Pyridine,2-(chloroMethyl)-4-Methoxy-3,5-diMethyl-, hydrochloride (1:1)

EsoMeprazo interMediate A

Omeprazole related substances 13

2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride &gt

2-CHLOROMETHYL- 3,5-DIMETHYL - 4 - METHOXY PYRIDINE HYDROCHLORIDE (OMEPRAZOLE CHLORO COMPOUND)

)-4-methoxy-3,5-dimethyL

2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride ISO 9001：2015 REACH

2-Chloromethyl-4-methoxy -3,5-dimethylpyridine hydrochloride (Ome Chloro)

Omeprazole Chloro Impurity

2-Chloromethyl-3,5-dimethyl-4-Methoxy pyridine Hydrochloride (Omeprazole Chloro)

2-Chloromethyl-4-methoxy-3,5-dimethyl pyridine HCLQ: What is 2-Chloromethyl-4-methoxy-3,5-dimethyl pyridine HCL Q: What is the CAS Number of 2-Chloromethyl-4-methoxy-3,5-dimethyl pyridine HCL Q: What is the storage condition of 2-Chloromethyl-4-methoxy-3,5-dimethyl pyridine HCL Q: What are the applications of 2-Chloromethyl-4-methoxy-3,5-dimethyl pyridine HCL

2-CHLORO METHYL-3,5-DIMETHLY-4-METHOXY PYRIDINE HCL

Esomeprazole INT

Esomeprazole Impurity 107

2-chloromethyl-3 5-dimethyl-4-methoxy pyridine hydrochloride (Omechloro)

Omeprazole Chloro

2-Chloromethyl-3,5-Dimethyl-4-Methoxy Pyridine Hydroc

2-(CHLOROMETHYL)-4-METHOXY-3,5-DIMETHYLPYRIDINE HYDROCHLORIDE (OMEPRAZOLE CHLORO)

2-Chloromethyl-4-Methoxy-3,5-Dimethylpyridine Hydrochl

Omeprazole EP Impurity XI 2-Chloromethyl-3,5-dimethyl-4-methoxypyridine HCl

2-Chloromethyl-3,5-dimethyl-4-methoxypyridine HCl (Ome Chloro)

2-Chloromethyl-3,5-dimethyl-4-methoxypyridine hydrochloride (Chloropyridine)

2-(Chloromethyl)-3,5-dimethoxypyridinehydrochloride

86604-75-3

8660-75-3