ChemicalBook > CAS DataBase List > 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride

2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride

Product Name
2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride
CAS No.
86604-75-3
Chemical Name
2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride
Synonyms
2-(CHLOROMETHYL)-4-METHOXY-3,5-DIMETHYLPYRIDINE HYDROCHLORIDE;Omeprazole chloride;2-CHLORO METHYL-3,5-DIMETHLY-4-METHOXY PYRIDINE HCL;CMDM;TENA-006;Esomeprazole INT;Omeprazole Chloro;86604-75-3C9H13CL2NO;2-Chloromethyl-4-met;Omeprazole Impurity 9
CBNumber
CB3226946
Molecular Formula
C9H13Cl2NO
Formula Weight
222.11
MOL File
86604-75-3.mol
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2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride Property

Melting point:
128-131 °C(lit.)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Sparingly)
form 
Solid
color 
White to Off-White
Water Solubility 
Soluble in water.
InChI
InChI=1S/C9H12ClNO.ClH/c1-6-5-11-8(4-10)7(2)9(6)12-3;/h5H,4H2,1-3H3;1H
InChIKey
LCJDHJOUOJSJGS-UHFFFAOYSA-N
SMILES
C1(CCl)=NC=C(C)C(OC)=C1C.[H]Cl
CAS DataBase Reference
86604-75-3(CAS DataBase Reference)
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Safety

Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
3261
WGK Germany 
3
HazardClass 
8
PackingGroup 
II
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
535508
Product name
2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride
Purity
98%
Packaging
5g
Price
$26.8
Updated
2025/07/31
Sigma-Aldrich
Product number
535508
Product name
2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride
Purity
98%
Packaging
25g
Price
$37.5
Updated
2025/07/31
TCI Chemical
Product number
C2269
Product name
2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$31
Updated
2025/07/31
TCI Chemical
Product number
C2269
Product name
2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$89
Updated
2025/07/31
TRC
Product number
C369240
Product name
2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride
Packaging
50g
Price
$255
Updated
2021/12/16
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2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride is used as pharmaceutical intermediates. It is an intermediate in the production of the antiulcer agent Omeprazole.

Synthesis

86604-78-6

86604-75-3

The general procedure for the synthesis of 2-chloromethyl-3,5-dimethyl-4-methoxypyridine hydrochloride from 4-methoxy-3,5-dimethyl-2-hydroxymethylpyridine was as follows: to a solution of 4-methoxy-3,5-dimethyl-2-hydroxymethylpyridine (25.1 g, 0.15 mol) in dichloromethane (400 mL) was added slowly and dropwise thionyl chloride (18.8 g, 0.158 mol) in dichloromethane (100 mL). 0.158 mol) to a solution of thionyl chloride (18.8 g, 0.158 mol) in dichloromethane (100 mL). The reaction was carried out at room temperature and under argon protection, and the titration process lasted for 30 minutes. After the dropwise addition, the reaction was continued with stirring at room temperature for 30 minutes. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The solid residue obtained was suspended in hexane (200 mL) and the solid was collected by filtration. The solid was washed with hexane (50 mL) and subsequently dried in air to afford 2-chloromethyl-3,5-dimethyl-4-methoxypyridine hydrochloride 33.3 g (100% yield) as a white solid.

References

[1] Patent: WO2004/9583, 2004, A2. Location in patent: Page 156
[2] Patent: US2005/38076, 2005, A1. Location in patent: Page/Page column 6
[3] Patent: CN107011252, 2017, A. Location in patent: Paragraph 0063; 0064; 0066; 0068; 0072; 0074
[4] Journal of Medicinal Chemistry, 1998, vol. 41, # 11, p. 1777 - 1788
[5] Patent: US5292886, 1994, A

2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride Preparation Products And Raw materials

Raw materials

2,3,5-Collidine

Preparation Products

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2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride Suppliers

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View Lastest Price from 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride 86604-75-3
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
10 tons
Release date
2021-08-09
Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride 86604-75-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-31
Henan Aochuang Chemical Co.,Ltd.
Product
2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride 86604-75-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-17

86604-75-3, 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochlorideRelated Search:

2-Pyridylacetic acid hydrochloride N,N-Dimethylformamide Pyridine hydrochloride 4-Methoxypyridine 4-Pyridineacetic acid hydrochloride 2-Chloro-6-methoxypyridine 2-(Chloromethyl)pyridine hydrochloride 2,6-Lutidine Topotecan hydrochloride Poly(dimethylsiloxane) 3-Pyridylacetic acid hydrochloride DIMETHYLAMINOPYRIDINE, POLYMER-BOUND 3-Picolyl chloride hydrochloride Dimethyl sulfoxide 4-(Chloromethyl)pyridine hydrochloride 2-Methoxyethanol N,N-Dimethylacetamide 4-Desmethoxy-4-nitro Omeprazole Sulfide

  • CMDM
  • Omeprazole intermediate
  • Omeprazole EP Impurity XI
  • 2-(chloromethyl)-4-methoxy-3,5-dimethyl-pyridine dyhydrochloride
  • Omeprazole chloride
  • 2-chloro-methyl-3,5-dimethyl-4-methoxy pyridine hcl (omeprazole-chloro compound)
  • Omeprazole Related Compound 13
  • Omeprazole Impurity W
  • Omeprazole Impurity 9
  • Omeprazole Related Compound 13 HCl
  • TENA-006
  • 86604-75-3C9H13CL2NO
  • 2-CHLOROMETHYL-3,5-DIMETHYL-4-METHOXYPYRIDINE HCL
  • 2-CHLOROMETHYL-3,5-DIMETHYL-4-METHOXYPYRIDINE HYDROCHLORIDE
  • 2-CHLOROMETHYL-4-METHOXY-3,5-DIMETHYL PYRIDINE HCL
  • 2-(CHLOROMETHYL)-4-METHOXY-3,5-DIMETHYLPYRIDINE HYDROCHLORIDE
  • 2-(CHLOROMETHYL)-4-METHOXY-3,5-LUTIDINE HCL
  • 2-CHLOROMETHYL-4-METHOXY-3,5-LUTIDINE HYDROCHLORIDE
  • 3,5-Dimethyl-2-chloromethyl-4-methoxypyridine hydrochloride
  • Esomeprazole Sodium Impurity 42
  • 2-Chloromethyl-3,5-dimethyl
  • Pyridine,2-(chloromethyl)-4-methoxy-3,5-dimethyl
  • 2-(CHLOROMETHYL)-4-METHOXY-3,5-DIMETHYL-PYRIDINEHYDROCHLORIDE(INTERMEDIATEOFOMEPRAXOLE)
  • 2-(CHLOROMETHYL)-4-METHOXY-3,5-DIMETHYL-PYRIDINE HDYROCHLORIDE
  • 2-CHLOROMETHYL-4-METHOXY-3,5-DIMETHYLPYRIDINE HCLOMEPRAZOLE
  • 2-Chloromethyl-4-met
  • (S)-Omeprazole Intermediate 1
  • 2-ChloroMethyl-4-Methoxy-3,5-diMethylpyridine hydrochloride 98%
  • 2-ChloroMethyl-3,5-diMethyl-4-Methoxy pyridine hydrochlorid
  • Omeprazole chloride compound
  • 2-Chloromethyl-4-methoxy-3,5-dimethylpyridinehydrochloride,98%
  • 2-ChloroMethyl-4-Methoxy-3,5-diMethylpyridine hydr
  • OMeprazole chloro interMediate
  • Pyridine,2-(chloroMethyl)-4-Methoxy-3,5-diMethyl-, hydrochloride (1:1)
  • EsoMeprazo interMediate A
  • Omeprazole related substances 13
  • 2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride &gt
  • 2-CHLOROMETHYL- 3,5-DIMETHYL - 4 - METHOXY PYRIDINE HYDROCHLORIDE (OMEPRAZOLE CHLORO COMPOUND)
  • )-4-methoxy-3,5-dimethyL
  • 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride ISO 9001：2015 REACH
  • 2-Chloromethyl-4-methoxy -3,5-dimethylpyridine hydrochloride (Ome Chloro)
  • Omeprazole Chloro Impurity
  • 2-Chloromethyl-3,5-dimethyl-4-Methoxy pyridine Hydrochloride (Omeprazole Chloro)
  • 2-Chloromethyl-4-methoxy-3,5-dimethyl pyridine HCLQ: What is 2-Chloromethyl-4-methoxy-3,5-dimethyl pyridine HCL Q: What is the CAS Number of 2-Chloromethyl-4-methoxy-3,5-dimethyl pyridine HCL Q: What is the storage condition of 2-Chloromethyl-4-methoxy-3,5-dimethyl pyridine HCL Q: What are the applications of 2-Chloromethyl-4-methoxy-3,5-dimethyl pyridine HCL
  • 2-CHLORO METHYL-3,5-DIMETHLY-4-METHOXY PYRIDINE HCL
  • Esomeprazole INT
  • Esomeprazole Impurity 107
  • 2-chloromethyl-3 5-dimethyl-4-methoxy pyridine hydrochloride (Omechloro)
  • Omeprazole Chloro
  • 2-Chloromethyl-3,5-Dimethyl-4-Methoxy Pyridine Hydroc
  • 2-(CHLOROMETHYL)-4-METHOXY-3,5-DIMETHYLPYRIDINE HYDROCHLORIDE (OMEPRAZOLE CHLORO)
  • 2-Chloromethyl-4-Methoxy-3,5-Dimethylpyridine Hydrochl
  • Omeprazole EP Impurity XI 2-Chloromethyl-3,5-dimethyl-4-methoxypyridine HCl
  • 2-Chloromethyl-3,5-dimethyl-4-methoxypyridine HCl (Ome Chloro)
  • 2-Chloromethyl-3,5-dimethyl-4-methoxypyridine hydrochloride (Chloropyridine)
  • 2-(Chloromethyl)-3,5-dimethoxypyridinehydrochloride
  • 86604-75-3
  • 8660-75-3