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CAFESTOL

Product Name
CAFESTOL
CAS No.
469-83-0
Chemical Name
CAFESTOL
Synonyms
CAFESTOL;CAFESTEROL;Ccris 1518;Cafestol-RM;CAFESTOL(SH);Cafestol (>85%);(1S,4S,12S,13R,16R,17R)-17-(hydroxymethyl)-12-methyl-8-oxapentacyclo[14.2.1.01,13.0,12.0,]nonadeca-5(9),6-dien-17-ol;3bα,4,5,6,7,8,9,10,10aα,10b,11,12-Dodecahydro-7β-hydroxy-10bβ-methyl-5aβ,8β-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7α-methanol;(3bS,5aS,7R,8R,10aR,10bS)-3b,4,5,6,7,8,9,10,10a,10b,11,12-Dodecahydro-7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol;5A,8-Methano-5ah-cyclohepta(5,6)naphtho(2,1-B)furan-7-methanol, 3B,4,5,6,7,8,9,10,10A,10B,11,12-dodecahydro-7-hydroxy-10B-methyl-, (3bs,5as,7R,8R,10ar,10bs)-
CBNumber
CB3228995
Molecular Formula
C20H28O3
Formula Weight
316.43
MOL File
469-83-0.mol
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CAFESTOL Property

Melting point:
160-162℃ (Decomposition) (ethyl ether pentane )
alpha 
D -101°
Boiling point:
468.6±45.0 °C(Predicted)
Density 
1.23±0.1 g/cm3 (20 ºC 760 Torr)
RTECS 
PB9185090
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
Soluble in dichlormethane, DMSO or ethanol
pka
14.44±0.40(Predicted)
form 
White to off-white solid.
color 
Off-White to Light Beige
optical activity
-9724 (CHCl3)
LogP
4.234 (est)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13999
Product name
Cafestol
Purity
≥98%
Packaging
5mg
Price
$48
Updated
2024/03/01
Cayman Chemical
Product number
13999
Product name
Cafestol
Purity
≥98%
Packaging
10mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
13999
Product name
Cafestol
Purity
≥98%
Packaging
50mg
Price
$210
Updated
2024/03/01
TRC
Product number
C079900
Product name
Cafestol(>85%)
Packaging
50mg
Price
$1295
Updated
2021/12/16
ChemScene
Product number
CS-0032793
Product name
Cafestol
Purity
99.91%
Packaging
5mg
Price
$99
Updated
2021/12/16
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CAFESTOL Chemical Properties,Usage,Production

Uses

Natural extract from coffee beans which induces glutathione S-transferase

Uses

Cafestol is a diterpene molecule that displays anti-carcinogenic properties in studies.

Definition

ChEBI: Cafestol is an organic heteropentacyclic compound and furan diterpenoid with formula C20H28O3 obtained from the unsaponifiable fraction of coffee oil (a lipid fraction obtained from coffee beans by organic solvent extraction). It has a role as a plant metabolite, an apoptosis inducer, a hypoglycemic agent, an angiogenesis inhibitor, an antineoplastic agent, an antioxidant and an anti-inflammatory agent. It is an organic heteropentacyclic compound, a tertiary alcohol, a diterpenoid, a member of furans and a primary alcohol.

in vivo

Cafestol (40-80 mg/kg; oral gavage ; 20 days) has antitumor effect in xenografted mouse model of colon cancer[3].
Cafestol (0.4-1.1 mg/day; feed administration; 10 weeks) shows antidiabetic activity in KKAy mice[4].

Animal Model:HCT116 cells treated BALB/C null mice[3]
Dosage:40 and 80 mg/kg
Administration:Oral gavage (i.g.); 20 days
Result:Increased the body weight, tumor suppression rate and decreased the tumor weight.
Did not change the colonic morphology.
Increased the richness and diversity of intestinal flora in tumor-bearing mice.
Stimulated autophagy in the colon tumors.
Animal Model:Male KKAy mice[4]
Dosage:0.4 and 1.1 mg/day
Administration:Feed administration; 10 weeks
Result:Reduced fasting plasma glucose and increased insulin secretion.
Reduced fasting glucagon was 20% lower and insulin sensitivity improved by 42% at dose of 1.1 mg.

IC 50

COX-2; NF-κB; ERK2

CAFESTOL Preparation Products And Raw materials

Raw materials

Preparation Products

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CAFESTOL Suppliers

Canada 1 China 115 Europe 2 Germany 1 India 2 Switzerland 1 United Kingdom 6 United States 15 USA 1 Global 144
Apin Chemicals Limited (UK)
Tel
--
Fax
--
Email
info@apinchemicals.com
Country
United Kingdom
ProdList
6184
Advantage
60
Leancare Ltd.
Tel
--
Fax
--
Email
enquiry@leancare.co.uk
Country
United Kingdom
ProdList
6446
Advantage
42
CARBONE SCIENTIFIC CO.,LTD
Tel
--
Fax
--
Email
sales@carbonesci.com
Country
United Kingdom
ProdList
6666
Advantage
30
ETA SCIENTIFIC Co.,Ltd
Tel
--
Fax
--
Email
sales@etascientific.com
Country
United Kingdom
ProdList
6090
Advantage
34
UK GREEN SCIENTIFIC CO.,LIMITED
Tel
--
Fax
--
Email
sales@gs-chem.com
Country
United Kingdom
ProdList
6098
Advantage
47
Apin Chemicals Ltd.
Tel
--
Fax
--
Email
info@apinchemicals.com
Country
United Kingdom
ProdList
6807
Advantage
42
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View Lastest Price from CAFESTOL manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
CAFESTOL 469-83-0
Price
US $1.00-100.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
300KG
Release date
2024-07-26
Career Henan Chemical Co
Product
CAFESTOL 469-83-0
Price
US $8.00/KG
Min. Order
1KG
Purity
＞98% HPLC
Supply Ability
20 tons
Release date
2020-02-17

469-83-0, CAFESTOLRelated Search:

1-AZAKENPAULLONE KAHWEOL SEDANOLIDE S-[N-(3-PHENYLPROPYL)(THIOCARBAMOYL)]-L-CYSTEINE 2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE CAFESTOL CAFESTOL ACETATE 2-N-OCTYLFURAN, 98 2-N-DODECYLFURAN 16-O-METHYL-CAFESTOL CAFESTOL PALMITATE CAFESTOL(RG) CAFESTOL PALMITATE(RG) CAFESTOL ACETATE(RG) CAFESTOL STEARATE CAFESTOL OLEATE CAFESTOL EICOSANATE CAFESTOL LINOLEATE

  • CAFESTEROL
  • CAFESTOL
  • 3bα,4,5,6,7,8,9,10,10aα,10b,11,12-Dodecahydro-7β-hydroxy-10bβ-methyl-5aβ,8β-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7α-methanol
  • 5A,8-Methano-5ah-cyclohepta(5,6)naphtho(2,1-B)furan-7-methanol, 3B,4,5,6,7,8,9,10,10A,10B,11,12-dodecahydro-7-hydroxy-10B-methyl-, (3bs-(3balpha,5abeta,7beta,8beta,10aalpha,10bbeta))-
  • 5A,8-Methano-5ah-cyclohepta(5,6)naphtho(2,1-B)furan-7-methanol, 3B,4,5,6,7,8,9,10,10A,10B,11,12-dodecahydro-7-hydroxy-10B-methyl-, (3bs,5as,7R,8R,10ar,10bs)-
  • Ccris 1518
  • CAFESTOL(SH)
  • (3bS,5aS,7R,8R,10aR,10bS)-3b,4,5,6,7,8,9,10,10a,10b,11,12-Dodecahydro-7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol
  • Cafestol (>85%)
  • (1S,4S,12S,13R,16R,17R)-17-(hydroxymethyl)-12-methyl-8-oxapentacyclo[14.2.1.01,13.0,12.0,]nonadeca-5(9),6-dien-17-ol
  • Cafestol-RM
  • 469-83-0
  • Di-Terpenoids