2-Chlorobenzoxazole
- Product Name
- 2-Chlorobenzoxazole
- CAS No.
- 615-18-9
- Chemical Name
- 2-Chlorobenzoxazole
- Synonyms
- 2-chlorobenzo[d]oxazole;2-Chloro-1,3-benzoxazole;orobenzoxazoL;2-chloro-benzoxazol;2-CHLOROBENZOXAZOLE;OTAVA-BB BB7020204750;Benzoxazole, 2-chloro-;Pemafibrate Impurity 3;Roxatidine Impurity 57;2-Chlorobenzoxazole,99%
- CBNumber
- CB3232204
- Molecular Formula
- C7H4ClNO
- Formula Weight
- 153.57
- MOL File
- 615-18-9.mol
2-Chlorobenzoxazole Property
- Melting point:
- 7 °C(lit.)
- Boiling point:
- 201-202 °C(lit.)
- Density
- 1.345 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.566(lit.)
- Flash point:
- 185 °F
- storage temp.
- Inert atmosphere,2-8°C
- form
- Powder
- pka
- 0.62±0.10(Predicted)
- color
- White
- Water Solubility
- Not miscible in water.
- BRN
- 115982
- InChI
- InChI=1S/C7H4ClNO/c8-7-9-5-3-1-2-4-6(5)10-7/h1-4H
- InChIKey
- BBVQDWDBTWSGHQ-UHFFFAOYSA-N
- SMILES
- O1C2=CC=CC=C2N=C1Cl
- CAS DataBase Reference
- 615-18-9(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzoxazole, 2-chloro-(615-18-9)
- EPA Substance Registry System
- Benzoxazole, 2-chloro- (615-18-9)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36/37/39-37/39-36
- WGK Germany
- 3
- RTECS
- DM4680000
- F
- 10
- TSCA
- Yes
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 274089
- Product name
- 2-Chlorobenzoxazole
- Purity
- 99%
- Packaging
- 10g
- Price
- $95.2
- Updated
- 2025/07/31
- Product number
- C1387
- Product name
- 2-Chlorobenzoxazole
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $30
- Updated
- 2025/07/31
- Product number
- C1387
- Product name
- 2-Chlorobenzoxazole
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $122
- Updated
- 2025/07/31
- Product number
- C429120
- Product name
- 2-Chlorobenzoxazole
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC05849
- Product name
- 2-Chlorobenzoxazole
- Packaging
- 500g
- Price
- $500
- Updated
- 2021/12/16
2-Chlorobenzoxazole Chemical Properties,Usage,Production
Chemical Properties
clear yellow liquid
Uses
2-Chlorobenzoxazole was used in the synthesis of 2-(2-naphthylamino)benzoxazole via reaction with 2-amino-1-naphthalenesulfonic acid.
Synthesis
2382-96-9
615-18-9
General procedure for the synthesis of 2-chlorobenzoxazole from 2-mercaptobenzoxazole: 2-mercaptobenzoxazole (10 mmol, 1.51 g) was suspended in SOCl2 (50 mL), and a few drops of DMF were added as catalyst. The reaction mixture was heated to reflux for 5 hours. After completion of the reaction, the solvent was removed by evaporation. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/EtOAc, 10:1) to afford the target compound as a colorless oil in 69.7% yield.
Purification Methods
Purify it by fractional distillation, preferably in a vacuum. [Siedel J Prakt Chem 42 456 1890, Katz J Am Chem Soc 75 712 1953, Meyer & Sigel J Org Chem 42 2769 1977, Beilstein 27 H 43, 27 II 17.]
References
[1] Patent: US4517370, 1985, A
[2] Heteroatom Chemistry, 2001, vol. 12, # 3, p. 151 - 155
[3] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 21, p. 5374 - 5379
[4] Patent: CN108794421, 2018, A. Location in patent: Paragraph 0028-0030
[5] Tetrahedron, 1986, vol. 42, # 14, p. 3905 - 3912
2-Chlorobenzoxazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chlorobenzoxazole manufacturers
- Product
- 2-Chlorobenzoxazole 615-18-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-22
- Product
- 2-Chlorobenzoxazole 615-18-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.5%
- Supply Ability
- 100 tons
- Release date
- 2022-02-20
- Product
- 2-Chlorobenzoxazole 615-18-9
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-23