ChemicalBook > CAS DataBase List > 1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE

1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE

Product Name: 1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE
CAS No.: 60787-05-5
Chemical Name: 1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE
Synonyms: 1-Acetyl-4-methylpiperazineHCl;1-(4-methyl-1-piperazinyl)Ethanone;1-(4-Methylpiperazin-1-yl)ethanone;1-(4-Methylpiperazin-1-yl)ethan-1-one;Ethanone, 1-(4-methyl-1-piperazinyl)-;1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE;1-Acetyl-4-methylpiperazine Hydrocholride
CBNumber: CB3233029
Molecular Formula: C7H14N2O
Formula Weight: 142.2
MOL File: 60787-05-5.mol

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1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE Property

Melting point:: 280 °C (decomp)
Boiling point:: 168 °C
Density: 1.017±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 6.84±0.10(Predicted)
Appearance: Colorless to light yellow Liquid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 0351
Product name: 1-Acetyl-4-methylpiperazinehydrochloride
Packaging: 10
Price: $73
Updated: 2021/12/16

Tocris

Product number: 0351
Product name: 1-Acetyl-4-methylpiperazinehydrochloride
Packaging: 50
Price: $271
Updated: 2021/12/16

TRC

Product number: A186870
Product name: 1-Acetyl-4-methylpiperazine
Packaging: 10mg
Price: $95
Updated: 2021/12/16

Usbiological

Product number: 254326
Product name: 1-Acetyl-4-methylpiperazine hydrochloride
Packaging: 10mg
Price: $395
Updated: 2021/12/16

Usbiological

Product number: 408687
Product name: 1-Acetyl-4-methylpiperazine Hydrochloride
Packaging: 50mg
Price: $672
Updated: 2021/12/16

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1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

1-Acetyl-4-methylpiperazine Hydrochloride is used in the preparation of (acetyl)piperazinium iodide and pyrrolopyrazinium iodides as nicotinic agonists.

Synthesis

109-01-3

108-24-7

60787-05-5

The general procedure for the synthesis of 1-acetyl-4-methylpiperazine from N-methylpiperazine and acetic anhydride was as follows: N-methylpiperazine (2.0 g, 19.97 mmol), triethylamine (3.35 mL, 23.96 mmol) and acetic anhydride (2.3 mL, 23.96 mmol) were dissolved in ethanol (60 mL) and the reaction was stirred at room temperature overnight. After completion of the reaction, the reaction mixture was concentrated to dryness under reduced pressure. The residue was purified by silica gel column chromatography using a mixed solvent of dichloromethane and methanol (with a gradient increase in the proportion of methanol) as eluent to afford the target product 1-acetyl-4-methylpiperazine (2.16 g, 76% yield) as a yellow oil. The product was characterized by 1H-NMR (CDCl3, 300 MHz) with chemical shifts δ: 3.65 (t, J = 6.8 Hz, 2H), 3.49 (t, J = 6.8 Hz, 2H), 2.46-2.39 (m, 4H), 2.32 (s, 3H), 2.10 (s, 3H) ppm.

References

[1] Patent: WO2014/6071, 2014, A1. Location in patent: Page/Page column 32
[2] Patent: EP2682391, 2014, A1. Location in patent: Paragraph 0112-0114

1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE Suppliers

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60787-05-5, 1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDERelated Search:

N,N'-DIACETYLGLYCINE ANHYDRIDE DIHYDROERGOTAMINE TARTRATE Ketoconazole 4-(1-Acetylpiperazin-4-yl)phenol Terazosin hydrochloride Praziquantel Prazosin ALPHA-ERGOCRYPTINE Bromocriptine mesylate Dihydroergotoxine 2-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]BENZOIC ACID FIPEXIDE HYDROCHLORIDE (2-CHLORO-3-PYRIDINYL)(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)METHANONE 2-(2-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)-2-OXOETHOXY)-1H-ISOINDOLE-1,3(2H)-DIONE [4-(6-CHLORO-2-PYRIDINYL)PIPERAZINO](4-FLUOROPHENYL)METHANONE ASISCHEM D08269 1-(3-CHLOROBENZYL)-3-[(4-METHYLPIPERAZINO)CARBONYL]-2(1H)-PYRIDINONE (Z)-3-(4-chlorophenyl)-1-(4-methylpiperazino)-2-propen-1-one

1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE

1-Acetyl-4-methylpiperazineHCl

1-Acetyl-4-methylpiperazine Hydrocholride

1-(4-Methylpiperazin-1-yl)ethan-1-one

1-(4-Methylpiperazin-1-yl)ethanone

1-(4-methyl-1-piperazinyl)Ethanone

Ethanone, 1-(4-methyl-1-piperazinyl)-

60787-05-5

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