ChemicalBook > CAS DataBase List > Hirsutine

Hirsutine

Product Name: Hirsutine
CAS No.: 7729-23-9
Chemical Name: Hirsutine
Synonyms: 16e)-;HIRSUTINE;Methyl (E)-2-[(2;Resorcinol Impurity 28;Hirsutine, 10 mM in DMSO;Mitragynine Impurity 8 (Hirsutine);corynan-16-carboxylicacid,16,17-didehydro-17-methoxy-,methylester,(3-bet;18-seco-3-beta-yohimban-16-carboxylicacid,16,17-didehydro-17-methoxy-1met;(3β,16E)-16,17-Didehydro-17-methoxycorynan-16-carboxylic acid methyl ester;(e)-16,17-didehydro-17-methoxy-17,18-seco-3-beta-yohimban-16-carboxylicacid
CBNumber: CB3233665
Molecular Formula: C22H28N2O3
Formula Weight: 368.47
MOL File: 7729-23-9.mol

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Hirsutine Property

Melting point:: 101 °C
Boiling point:: 531.7±50.0 °C(Predicted)
Density: 1.20±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 18.13±0.60(Predicted)
color: White to off-white
InChIKey: NMLUOJBSAYAYEM-YUPRPPKRNA-N
SMILES: [C@]12([H])C[C@@H]([C@@H](CC)CN1CCC1C3=C(C=CC=C3)NC2=1)/C(=C\OC)/C(=O)OC |&1:0,3,4,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3507
Product name: Hirsutine
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $63.46
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3507
Product name: Hirsutine
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $268
Updated: 2025/07/31

Usbiological

Product number: 300418
Product name: Hirsutine
Packaging: 5mg
Price: $632
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb259292
Product name: Hirsutine
Purity: 98%
Packaging: 5mg
Price: $778.6
Updated: 2021/12/16

ChemScene

Product number: CS-0019501
Product name: Hirsutine
Purity: ≥99.0%
Packaging: 5mg
Price: $1143
Updated: 2021/12/16

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Hirsutine Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Uncaria rhynchophylla (Miq.) Miq. ex Havil.

Uses

Hirsutine, an indole alkaloid of Uncaria rhynchophylla, exhibits anti-cancer activity. Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity[1][2][3].

Biological Activity

Hirsutine is a brain penetrant alkaloid from Uncaria rhynchophylla th at exhibit anti-cancer, cardioprotective, anti-hypertensive, and anti-arrhythmic activities. It appears th at hirsutine induces apoptosis in lung cancer cells through opening of mitochondrial permeability transition pore (mPTP). Hirsutine exhibit potent anti-dengue virus activity.

in vivo

Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells^[3].

References

[1] Hishiki T, et al. Hirsutine, an Indole Alkaloid of Uncaria rhynchophylla, Inhibits Late Step in Dengue Virus Lifecycle. Front Microbiol. 2017 Aug 30;8:1674. DOI:10.3389/fmicb.2017.01674
[2] Huang QW, et al. [Hirsutine induces apoptosis of human breast cancer MDA-MB-231 cells through mitochondrial pathway]. Sheng Li Xue Bao. 2018 Feb 25;70(1):40-46. PMID:29492513
[3] Zhang R, et al. Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells. Cell Death Dis. 2018 May 22;9(6):598. DOI:10.1038/s41419-018-0641-7

Hirsutine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Hirsutine manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: Hirsutine 7729-23-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-24

Shanghai Standard Technology Co., Ltd.

Product: Hirsutine 7729-23-9
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-03-24

Career Henan Chemical Co

Product: Hirsutine 7729-23-9
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-09

7729-23-9, HirsutineRelated Search:

Methanol Methyl acrylate Methyl salicylate corynoxeine Methylparaben Pilocarpine nitrate PILOCARPINE Kresoxim-methyl METSULFURON METHYL Isorhychophylline Dihydroergotoxine mesylate Rhynchophylline Tribenuron methyl Basic Violet 1 Methyl AZINPHOS-METHYL Δ18-Hirsutine Hirsutine

HIRSUTINE

(e)-16,17-didehydro-17-methoxy-17,18-seco-3-beta-yohimban-16-carboxylicacid

16e)-

18-seco-3-beta-yohimban-16-carboxylicacid,16,17-didehydro-17-methoxy-1met

corynan-16-carboxylicacid,16,17-didehydro-17-methoxy-,methylester,(3-bet

Methyl (E)-2-[(2S,3R,12bR)-3-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[3,2-h]quinolizin-2-yl]-3-methoxyprop-2-enoate

(3β,16E)-16,17-Didehydro-17-methoxycorynan-16-carboxylic acid methyl ester

Methyl (E)-2-[(2

Indolo[2,3-a]quinolizine-2-acetic acid, 3-ethyl-1,2,3,4,6,7,12,12b-octahydro-α-(methoxymethylene)-, methyl ester, (αE,2S,3R,12bR)-

methyl(E)-2-[(2S,3R,12bR)-3-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-methoxyprop-2-enoate

Mitragynine Impurity 8 (Hirsutine)

Resorcinol Impurity 28

Hirsutine, 10 mM in DMSO

(E)-Methyl 2-((2S,3R,12bR)-3-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate

7729-23-9