ChemicalBook > CAS DataBase List > lannaconitine

lannaconitine

Product Name
lannaconitine
CAS No.
32854-75-4
Chemical Name
lannaconitine
Synonyms
LAPPACONITINE;Lannaconitine;Aconitum extract;(+)-Lappacontine;(+)-Lappaconitine;N-Acetylpuberanidine;(+)-Lappaconitine >90%;Giant Typhonium Rhizome;Aconitum kusnezoffii Reichb;acetyl-10-deoxysepaconitine
CBNumber
CB3235290
Molecular Formula
C32H44N2O8
Formula Weight
584.7
MOL File
32854-75-4.mol
More
Less

lannaconitine Property

Melting point:
217-218°
alpha 
D18 +27° (chloroform)
Boiling point:
641.72°C (rough estimate)
Density 
1.1897 (rough estimate)
refractive index 
1.6260 (estimate)
storage temp. 
Store at 2-8°C, protect from light
solubility 
Chloroform: 30 mg/ml
form 
A solid
pka
12.55±0.70(Predicted)
Stability:
Hygroscopic
More
Less

Safety

Toxicity
LD50 in mice (mg/kg): 6.9 i.v.; 9.1 i.p.; approx 20 orally (Dybing)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Usbiological
Product number
300548
Product name
Lappaconitine
Packaging
20mg
Price
$295
Updated
2021/12/16
TRC
Product number
L175850
Product name
(+)-Lappaconitine>90%
Packaging
100mg
Price
$150
Updated
2021/12/16
Biorbyt Ltd
Product number
orb594064
Product name
Lappaconitine
Packaging
20mg
Price
$204
Updated
2021/12/16
ChemScene
Product number
CS-3588
Product name
Lappaconitine
Purity
98.04%
Packaging
100mg
Price
$250
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
41161
Product name
(+)-Lappaconitine
Packaging
250mg
Price
$800
Updated
2021/12/16
More
Less

lannaconitine Chemical Properties,Usage,Production

Description

A highly toxic aconitine alkaloid present in Aconitum leucostomum and A. septentrionale Koelle, lappaconitine crystallizes in hexagonal tablets for whichtwo melting points have been recorded. It has [α]D + 22.3° (C6H6) or [α]18D + 27.0° (CHC1 3). The early view that a methylimino group is present has been shown to be erroneous. No crystalline salts are known but the diacetyl derivative forms colourless crystals, m.p. l25-7°C. The base is only sparingly soluble in H20 and most organic solvents, but dissolves readily in CHC1 3.
Boiling the alkaloid with dilute H2S04 in a stream of H2 yields acetic acid and anthranoyllappaconine, C30H4207N2, which forms colourless rhombic tablets, m.p. 146-9°C;[α]25D + 22.07° (C6H6), giving a platinichloride tetrahydrate as brown needles, m.p. 300-31 O°C (dec.). When hydrolyzed with HCl, the base furnishes acetic and anthranilic acids and lappaconine, m.p. 96°C; [α]25D + 22.41°, giving a crystalline hydrochloride, m.p. 246-7°C and the aurichloride monohydrate, m.p. l26-7°C. Alkaline hydrolysis, on the other hand, furnishes lappaconine and lappaconitic acid (acetylanthranilic acid). From these observations, it is clear that only one hydroxyl group is associated with an acyl group in the molecule.
Pharmacologically, lappaconitine is toxic although its action is less pronounced than that of aconitine (q.v.). Toxic doses produce respiratory paralysis and have a direct action upon the heart often terminating in ventricular fibrillation.

Uses

(+)-Lappaconitine is a potential antitumor agent agent that induces HL-60 differentiation and apoptosis with analgesic activity as well.

References

Schultze, Ulfert., Arch. Pharrn., 260,230 (1922)
Weidemann., Chern. Zentr., 1,603 (1923)
Khaimova et al., Tetrahedron Lett., 2711 (1964)
Structure:
Tel'nov, Yunusov, Yunusov., Khirn. Prir. Soedin., 6, 583 (1970)
Pharmacology:
Rosendahl., quoted by Boehm,!. BioI. Chern., 170,203 (1947)

lannaconitine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

lannaconitine Suppliers

China 181 Europe 2 Germany 2 India 1 United Kingdom 3 United States 21 Global 210
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2784
Advantage
58
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8449
Advantage
60
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4662
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6254
Advantage
58
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6824
Advantage
0
Wilshire Chemical Company Inc.
Tel
--
Fax
--
Email
WilshrChem@AOL.COM
Country
United States
ProdList
3500
Advantage
58
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6971
Advantage
56
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6618
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6256
Advantage
80
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6801
Advantage
30
FortopChem Technology Limited
Tel
--
Fax
--
Email
sales@fortopchem.com
Country
United States
ProdList
1099
Advantage
50
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6148
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6744
Advantage
47
LKT Laboratories, Inc.
Tel
--
Fax
--
Email
info@lktlabs.com
Country
United States
ProdList
2164
Advantage
64
ChromaDex
Tel
--
Fax
--
Email
sales@chromadex.com
Country
United States
ProdList
2501
Advantage
76
More
Less

View Lastest Price from lannaconitine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
lannaconitine 32854-75-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-08-01
Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Lappaconitine 32854-75-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-04-10
Henan Fengda Chemical Co., Ltd
Product
lannaconitine 32854-75-4
Price
US $6.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-28

32854-75-4, lannaconitineRelated Search:

L-Hyoscyamine Xanthiazone veratramine Xanthiside daurisoline Aconitine (1a,14a,16b)-20-Ethyl-1,14,16-trimethoxyaconitane-4,8,9-triol 4-(2-(acetylamino)benzoate) hydrobromide N-deacetyllappaconitine DECYL ANTHRANILATE Isobutyl anthranilate 1-[(dimethylamino)methyl]-1-methylpropyl benzoate lannaconitine tert-Butyl 2-aminobenzoate iso-amylanthranilate 4-Benzoyloxycyclohexanol 3-(BENZYLOXY)PIPERIDINE CYCLOHEXYL ANTHRANILATE 3-Piperidinol,1,2,3-trimethyl-

  • (1a,14a,16b)-20-Ethyl-1,14,16-trimethoxyaconitane-4,8,9-triol 4-(2-acetylamino)benzoate)
  • (1α,14α,16β)-20-Ethyl-1,14,16-trimethoxyaconitane-
  • 4,8,9-triol4-[2-(acetylamino)benzoate]
  • Aconitane-4,8,9-triol, 20-ethyl-1,14,16-trimethoxy-, 4-(2-acetylamino)benzoate, (1-alpha,14-alpha,16-beta)
  • 20-Ethyl-1α,14α,16β-trimethoxyaconitane 4,8,9-triol 4-[2-(acetylamino)benzoate]
  • 20-Ethyl-1α,14α,16β-trimethoxyaconitane-4,8,9-triol 4-[2-(acetylamino)benzoate]
  • N-Acetylpuberanidine
  • Lannaconitine
  • Aconitum kusnezoffii Reichb
  • LAPPACONITINE
  • Aconitum extract
  • ,(1-alpha,14-alpha,16-beta)-
  • 8,9-triol,20-ethyl-1,14,16-trimethoxy-aconitane-4-(2-acetylamino)benzoate)
  • acetyl-10-deoxysepaconitine
  • Giant Typhonium Rhizome
  • Lappaconitine, 98%, from Aconitum sinomontanum Nakai
  • Lappaconitine ((+)-Lappaconitine)
  • Aconitane-4,8,9-triol, 20-ethyl-1,14,16-trimethoxy-, 4-[2-(acetylamino)benzoate], (1α,14α,16β)-
  • (+)-Lappaconitine
  • (+)-Lappaconitine >90%
  • Aconitum Sinomontanum Nakai Extract
  • (+)-Lappacontine
  • C32H44N2O8 (1a,14a,16b)-20-Ethyl-1,14,16-trimethoxyaconitane-4,8,9-triol 4-(2-acetylamino)benzoate)
  • 20-Ethyl-1α,14α,16β-trimethoxyaconitane 4,8,9-triol 4-[2-(acetylamino)benzoate]
  • 32854-75-4
  • C32H44N2O8
  • Inhibitors
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract