ChemicalBook > CAS DataBase List > 2-Cyanobenzyl bromide

2-Cyanobenzyl bromide

Product Name
2-Cyanobenzyl bromide
CAS No.
22115-41-9
Chemical Name
2-Cyanobenzyl bromide
Synonyms
2-(BROMOMETHYL)BENZONITRILE;ALPHA-BROMO-O-TOLUNITRILE;Ortho Cyano Benzyl Bromide;AKOS 92624;Alogliptin-2;AKOS BBS-00000052;Cyanobenzyl bromide;α-Bromo-o-toluntrile;A-BROMO-O-TOLUNITRILE;2-CYANOBENZYL BROMIDE
CBNumber
CB3241402
Molecular Formula
C8H6BrN
Formula Weight
196.04
MOL File
22115-41-9.mol
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2-Cyanobenzyl bromide Property

Melting point:
72-74 °C(lit.)
Boiling point:
111 °C / 1.5mmHg
Density 
1.5466 (rough estimate)
refractive index 
1.6550 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
Water Solubility 
Slightly soluble in water
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
Crystalline Powder or Chunks
color 
White to gray-brown
BRN 
742605
InChIKey
QGXNHCXKWFNKCG-UHFFFAOYSA-N
CAS DataBase Reference
22115-41-9(CAS DataBase Reference)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45-28A
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
F 
10-19-21
Hazard Note 
Corrosive
HazardClass 
8
PackingGroup 
II
HS Code 
29269090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
144711
Product name
2-(Bromomethyl)benzonitrile
Purity
≥97%
Packaging
5g
Price
$49.1
Updated
2024/03/01
Sigma-Aldrich
Product number
144711
Product name
2-(Bromomethyl)benzonitrile
Purity
≥97%
Packaging
25g
Price
$64
Updated
2024/03/01
TCI Chemical
Product number
C1556
Product name
2-Cyanobenzyl Bromide
Purity
>98.0%(GC)
Packaging
10g
Price
$68
Updated
2024/03/01
TCI Chemical
Product number
C1556
Product name
2-Cyanobenzyl Bromide
Purity
>98.0%(GC)
Packaging
25g
Price
$132
Updated
2024/03/01
Alfa Aesar
Product number
B24278
Product name
2-(Bromomethyl)benzonitrile, 98%
Packaging
25g
Price
$135.65
Updated
2024/03/01
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2-Cyanobenzyl bromide Chemical Properties,Usage,Production

Description

2-(Bromomethyl)benzonitrile reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)meth-yl]benzonitrile. It undergoes base-promoted condensation reaction with homophthalic anhydride to yield 6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one.

Chemical Properties

White to light yellow crystal powder

Uses

2-(Bromomethyl)benzonitrile is an intermediate in the synthesis of Alogliptin, an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Antidiabetic agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package.

General Description

2-(Bromomethyl)benzonitrile reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)meth-yl]benzonitrile. It undergoes base-promoted condensation reaction with homophthalic anhydride to yield 6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one.

Purification Methods

Purify the nitrile by steam distillation. Extract the distillate with Et2O, dry the extract (Na2SO4), evaporate and distil the residue. The solidified distillate can be recrystallised from pet ether or cyclohexane. NMR (CDCl3) : 7.8-7.2 (m 4H), 4.62 (s, 2H), IR max 2238 cm1 . [Drory Chem Ber 24 2570 1891, Borsche et al. Chem Ber 74 685 1934, Buckley et al. Aust J Chem 22 594 1969, Beilstein 9 III 2312.] LACHRYMATORY.

2-Cyanobenzyl bromide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Cyanobenzyl bromide manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
2-Cyanobenzyl bromide 22115-41-9
Price
US $30.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000kg
Release date
2024-03-22
Nanjing Fred Technology Co., Ltd
Product
2-Cyanobenzyl bromide 22115-41-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2024-01-03
Zibo Hangyu Biotechnology Development Co., Ltd
Product
2-Cyanobenzyl bromide 22115-41-9
Price
US $85.00-850.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-13

22115-41-9, 2-Cyanobenzyl bromideRelated Search:

Sodium cyanoborohydride Benzonitrile Sodium bromate Methylene dithiocyanate Allyl bromide Ethidium bromide Ethyl N-cyanoethanimideate Benzyl bromide Rocuronium bromide Diethylstilbestrol ETHYL 2-CYANOACRYLATE α-Bromocinnamaldehyde 2-CYANO-4-FLUOROBENZYL BROMIDE Benzeneacetonitrile 4-Nitrobenzyl bromide 2-cyano-5-fluorobenzylbroMide Bromine Methyl bromide

  • Adjacent cyano benzyl broMide
  • O-CYANOBENZYL BROMIDE
  • ALPHA-BROMO-O-TOLUNITRILE
  • ALPHA-BROMO-O-TOLUONITRILE
  • AKOS 92624
  • AKOS BBS-00000052
  • A-BROMO-O-TOLUNITRILE
  • alpha-bromo-ortho-tolunitrile
  • 2-CYANOBENZYL BROMIDE
  • 2-(BROMOMETHYL)BENZONITRILE
  • 2-Cyanobenzyl bromide 2-(Bromomethyl)benzonitrile
  • o-Cyanobenzyl Bromid 2-(Bromomethyl)Benzonitrile
  • Alogliptin-2
  • 2-(Bromomethyl)benzonitrile >=97%
  • α-Bromo-o-toluntrile
  • a-Bromo-o-tolunitrile, (2-Cyanobenzyl bromide)
  • ALPHA-BROMO-ORTHO-TOLUNITRILE, 97+%
  • Alpha-Bromo-O-Tolunitrile98%
  • Benzonitrile, 2-(bromomethyl)-
  • à-bromo-o-tolunitrile
  • α-bromo-o-tolunitrile
  • 2-Cyanobenzyl bromide 98%
  • 2-Cyanobenzylbromide98%
  • 2-CYANIDE BENZYL BROMIDE 99+%
  • 2-(Bromomethyl)benzonitrile, 97% - (See B24278)
  • α-Bromo-o-tolunitrile, 2-Cyanobenzyl bromide
  • 2-(bromomethy)benzonitrile
  • 2-(Bromomethyl)benzonitrile,98%
  • α-Bromo-o-tolunitrile ,97%
  • -Cyano benzyl broMide (O-Cyano benzyl broMide)
  • 2-(Bromomethyl)benzonitrile 98%
  • 2-(Bromomethyl)benzonitrile alpha-Bromo-o-tolunitrile
  • o-(Bromomethyl)benzonitrile
  • (2-Cyanophenyl)Methyl broMide
  • 2-CyanobenzylBromide&gt
  • Cyanobenzyl bromide
  • Ortho Cyano Benzyl Bromide
  • alogliptin impurities160
  • alogliptin impurities13
  • alpha-Bromo-o-tolunitrile,2-Cyano benzyl bromide
  • 1-Pyrrolidinepropanoicacid,2,11-dioxo-
  • Alpha bromo toluoyl nitrile
  • (2-Cyanophenyl)methyl bromide (Alogliptin Impurity)
  • Alogliptin intermediate 2-Cyanobenzyl bromide
  • 22115-41-9
  • 22115-14-9
  • 2215-41-9
  • BrCH2C6H4CN
  • Cyanides/Nitriles
  • Organic Building Blocks
  • Nitrogen Compounds
  • C8 to C9
  • Building Blocks
  • cyanide| alkyl bromide
  • 22115-41-9