ChemicalBook > CAS DataBase List > 7-BROMO-4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

7-BROMO-4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

Product Name: 7-BROMO-4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
CAS No.: 206257-41-2
Chemical Name: 7-BROMO-4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
Synonyms: Ethyl 7-broMo-4-chloroquinoline-3-carboxylate;Ethyl 4-chloro-7-broMoquinoline-3-carboxylate;7-bromo-4-chloro-3-Quinolinecarboxylic acid ethyl ester;7-BROMO-4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER;Ethyl 7-bromo-4-chloroquinoline-3-carboxylate - [E71506];3-Quinolinecarboxylic acid, 7-bromo-4-chloro-, ethyl ester
CBNumber: CB32450002
Molecular Formula: C12H9BrClNO2
Formula Weight: 314.56
MOL File: 206257-41-2.mol

Less

7-BROMO-4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER Property

Boiling point:: 378.3±37.0 °C(Predicted)
Density: 1.578±0.06 g/cm3(Predicted)
storage temp.: Storage temp. -20°C
pka: 0.23±0.38(Predicted)
Appearance: White to off-white Solid

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0359929
Product name: 7-BROMO-4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
Purity: 95.00%
Packaging: 5MG
Price: $505.53
Updated: 2021/12/16

Crysdot

Product number: CD11168024
Product name: Ethyl7-bromo-4-chloroquinoline-3-carboxylate
Purity: 97%
Packaging: 250mg
Price: $56
Updated: 2021/12/16

Chemenu

Product number: CM145738
Product name: ethyl7-bromo-4-chloroquinoline-3-carboxylate
Purity: 97%
Packaging: 1g
Price: $112
Updated: 2021/12/16

Crysdot

Product number: CD11168024
Product name: Ethyl7-bromo-4-chloroquinoline-3-carboxylate
Purity: 97%
Packaging: 1g
Price: $140
Updated: 2021/12/16

Abosyn

Product number: 10-1865
Product name: 7-Bromo-4-chloro-quinoline-3-carboxylicacidethylester
Purity: >95%
Packaging: 1g
Price: $199
Updated: 2021/12/16

Less

7-BROMO-4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Synthesis

208580-23-8

206257-41-2

Ethyl 7-bromo-4-hydroxyquinoline-3-carboxylate (DK-I-49-1, 11.0 g, 37.1 mmol) was heated to 35-40 °C in a solvent mixture of N,N-dimethylformamide (0.1 mL, 1.3 mmol) and dichloromethane (50 mL). Oxalyl chloride (5.2 g, 40.9 mmol) was slowly added dropwise to the reaction mixture over 30 minutes. Subsequently, the reaction mixture was heated at reflux temperature (38-40 °C) for 1 hour. After completion of the reaction, the resulting brown solution was cooled to 20-25 °C. The reaction mixture was diluted with dichloromethane (150 mL) and then neutralized by slowly adding 25% aqueous potassium carbonate solution (12.5 g potassium carbonate dissolved in 50 mL of water). The organic and aqueous layers were separated and the aqueous layer was extracted with dichloromethane (50 mL). The organic layers were combined and washed with 25% aqueous potassium carbonate (12.5 g potassium carbonate dissolved in 50 mL of water). The combined organic layers were dried over magnesium sulfate. The solvent was removed by rotary evaporation and the product residue was slurried with hexane (50 mL). The solid product was filtered and washed twice with hexane (25 mL x 2). The solid was dried to afford the target product ethyl 4-chloro-7-bromoquinoline-3-carboxylate (DK-I-54-1, 7.2 g, 61% yield) as an off-white solid. The structure of the product was confirmed by 1H NMR, 13C NMR and HRMS: 1H NMR (300 MHz, DMSO) δ 9.15 (s, 1H), 8.36 (d, J = 1.9 Hz, 1H), 8.28 (d, J = 9.0 Hz, 1H), 7.98 (dd, J = 9.0, 1.9 Hz, 1H), 4.44 (q, J = 7.1 Hz, 2H), 1.39 (t, J = 7.1 Hz, 3H); 13C NMR (75 MHz, DMSO) δ 164.04, 151.40, 149.74, 142.34, 132.67, 131.88, 127.50, 126.64, 124.70, 123.96, 62.55, 14.46. HRMS m/z calculated for C12H10BrClNO2 (M + H)+ 313.9583, found 314.05.

References

[1] Patent: WO2016/196961, 2016, A1. Location in patent: Paragraph 00150
[2] Journal of Medicinal Chemistry, 2018, vol. 61, # 6, p. 2422 - 2446
[3] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 8, p. 1487 - 1490

7-BROMO-4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

Less

7-BROMO-4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER Suppliers

China 40 United States 1 Global 41

Nanjing Habo Medical Technology Co., Ltd.

Tel: 025-85760892 13376080562
Fax: 025-85766769
Email: sales@habotech.com
Country: China
ProdList: 884
Advantage: 60

ShangHai AmK Pharmaceutical Technology Co., Ltd.

Tel: 微信 17321281695 18019252918
Fax: 17321281695
Email: sale@amkchem.com
Country: China
ProdList: 15136
Advantage: 55

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 16679
Advantage: 50

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Xi'an NewProChem Co.,Ltd.

Tel: 15332490153
Fax: QQ 2725398181
Email: newprochem@126.com
Country: China
ProdList: 991
Advantage: 55

Quzhou AMK BioTech Co., Ltd

Tel: 0570-3081766 18357083060
Fax: 0570-3072337
Email: sales@qzamkbio.com
Country: China
ProdList: 1047
Advantage: 55

Shanghai Changyan Chem & Tech Co., Ltd.

Tel: 021-20242659 18930833303
Fax: +86 (21) 2024-2659
Email: Sales@changyanchem.cn
Country: China
ProdList: 5001
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

Suzhou Nuoouman Biological Technology Co., Ltd.

Tel: 15026866316
Email: 180642609@qq.com
Country: China
ProdList: 4967
Advantage: 58

Rhawn Reagent

Tel: 400-400-1332688 18019345275
Fax: 400-133-2688
Email: amy@rhawn.cn
Country: China
ProdList: 14948
Advantage: 58

Yujinpharma(Tianjin) Technology Co.,Ltd.

Tel: 13370351217 kungfu1217@1
Fax: QQ1400885609
Email: kungfu1217@163.com
Country: China
ProdList: 2720
Advantage: 58

SuZhou Medinoah Co.,LTD.

Tel: 0512-69561983 13914027025
Fax: 0512-69561982
Email: zhang_q@medinoah.com
Country: China
ProdList: 3811
Advantage: 58

Shanghai Maruhua Science and Technology Co. Ltd.

Tel: 021-57171708 18721745940
Fax: QQ1139783351
Email: sales@api-chem.com
Country: China
ProdList: 1968
Advantage: 58

Shanghai Medicil Biomedical Co., Ltd.

Tel: 021-50822001
Email: marketing@medicilon.com.cn
Country: China
ProdList: 1152
Advantage: 58

wuhan Dekray Biomedical Technology Co.,Ltd

Tel: 027-69573188 18221423799
Email: 1503407886@qq.com
Country: China
ProdList: 1439
Advantage: 58

Nanjing Asfam Pharmaceutical Technology Co., Ltd.

Tel: 025-58867862 18751812725
Fax: 02558867862
Email: sales@ace-pharm.com
Country: China
ProdList: 1985
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

Labnetwork lnc.

Tel: +86-27-50766799 +8618062016861
Email: contact@labnetwork.com
Country: China
ProdList: 19987
Advantage: 58

Shanxi Xuanran Import and Export Trade Co., Ltd.

Tel: +8617735180244
Email: mike_yan@xuanranglobal.com
Country: CHINA
ProdList: 4017
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

Shanghai Lanle Bird Industrial Co., Ltd.

Tel: 15021845385
Email: 765325601@qq.com
Country: China
ProdList: 3609
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-029-81024372 17792795018
Fax: 029-88380327
Email: 1027@dideu.com
Country: China
ProdList: 10003
Advantage: 58

Zhengzhou Alpha Chemical Co. LTD

Tel: 0371-0371-53732842 13383863444
Fax: QQ：3002612166
Email: 3002612166@qq.com
Country: China
ProdList: 9996
Advantage: 58

Chongqing Kemai Material Technology Co., Ltd

Tel: 17830741407
Fax: QQ：2479150351
Email: sales@chem47.com
Country: China
ProdList: 1768
Advantage: 58

Hubei Co-prosperity Medicine Technonlogy Co., Ltd

Tel: 2383948258 19172820304
Email: 2383948258@qq.com
Country: China
ProdList: 12987
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39653
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Abosyn

Tel: 0512-69561983 13914027025
Email: he_qf@medinoah.com
Country: China
ProdList: 3001
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29995
Advantage: 58

Changzhou Qianai Biotechnology Co., Ltd

Tel: 051915240519135 13961152745
Email: yudiguimo@126.COM
Country: China
ProdList: 10000
Advantage: 58

Shanghai Ken chemical Technology Co.,ltd

Tel: 02152215958
Email: 47697177@qq.com
Country: China
ProdList: 10011
Advantage: 58

Shenzhen Nexcon Pharmatechs Ltd.

Tel: +86-0755-89396905 +86-18025329037
Email: admin@nexconn.com
Country: China
ProdList: 3255
Advantage: 58

Shanxi Tihondan Pharmaceutical Technology Co., Ltd

Tel: +8618235132063
Email: sales@tihondan.com
Country: China
ProdList: 3767
Advantage: 58

Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd.

Tel: +86-029-86185165 +8618629664246
Email: guoyuan@eastchinapharm.com
Country: China
ProdList: 1615
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Debye Scientific Corporation

Tel: --
Fax: --
Country: China
ProdList: 6891
Advantage: 50

206257-41-2, 7-BROMO-4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTERRelated Search:

6-CYANO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER AURORA 17787 6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE 7-BROMO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE ethyl 4-chloro-6-methoxy-quinoline-3-carboxylate ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE 4-CHLORO-6,7-DIMETHOXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 7-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID 6,7-DIMETHOXY-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE 4-CHLORO-6-IODO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 7-BROMO-4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 7-BROMO-4-CHLOROQUINOLINE 7-BROMOQUINOLINE-3-CARBOXYLIC ACID ethyl 7-bromo-2-oxo-2H-chromene-3-carboxylate ethyl 6-hydroxybenzo[b]thiophene-5-carboxylate

7-BROMO-4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

Ethyl 4-chloro-7-broMoquinoline-3-carboxylate

Ethyl 7-broMo-4-chloroquinoline-3-carboxylate

7-bromo-4-chloro-3-Quinolinecarboxylic acid ethyl ester

3-Quinolinecarboxylic acid, 7-bromo-4-chloro-, ethyl ester

Ethyl 7-bromo-4-chloroquinoline-3-carboxylate - [E71506]

206257-41-2