3-Thiophenecarbonitrile
- Product Name
- 3-Thiophenecarbonitrile
- CAS No.
- 1641-09-4
- Chemical Name
- 3-Thiophenecarbonitrile
- Synonyms
- THIOPHENE-3-CARBONITRILE;3-cyanothiophen;3-CYANOTHIOPHENE;BUTTPARK 96\11-31;3-Thiophenecarbonitr;3-Cyanothiophene >3-THIOPHENECARBONITRILE;Thiophen-3-carbonitrile;3-Thiophenecarbonitrile 95%;3-Thiophenecarbonitrile,94%
- CBNumber
- CB3245804
- Molecular Formula
- C5H3NS
- Formula Weight
- 109.15
- MOL File
- 1641-09-4.mol
3-Thiophenecarbonitrile Property
- Boiling point:
- 82 °C10 mm Hg(lit.)
- Density
- 1.2 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.5630(lit.)
- Flash point:
- 186 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- Liquid
- Specific Gravity
- 1.2
- color
- Clear colorless
- BRN
- 107104
- CAS DataBase Reference
- 1641-09-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36-36/37
- RIDADR
- 3276
- WGK Germany
- 3
- Hazard Note
- Harmful
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29341000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 597449
- Product name
- 3-Thiophenecarbonitrile
- Purity
- 95%
- Packaging
- 5g
- Price
- $36.7
- Updated
- 2025/07/31
- Product number
- 597449
- Product name
- 3-Thiophenecarbonitrile
- Purity
- 95%
- Packaging
- 25g
- Price
- $156
- Updated
- 2025/07/31
- Product number
- C1344
- Product name
- 3-Cyanothiophene
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $48
- Updated
- 2025/07/31
- Product number
- C1344
- Product name
- 3-Cyanothiophene
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $192
- Updated
- 2025/07/31
- Product number
- 291449
- Product name
- Thiophene-3-carbonitrile
- Packaging
- 10g
- Price
- $337
- Updated
- 2021/12/16
3-Thiophenecarbonitrile Chemical Properties,Usage,Production
Chemical Properties
Clear colorless liquid
Uses
3-Thiophenecarbonitrile can be used to synthesize the following:
- 2,4-dinaphthyl-3-cyanothiophene via reaction with iodonaphthalene
- 2,5-bis-tri(n-butyl)tin-3-cyanothiophene, a building block for the synthesis of new alternating (3-alkyl/3-cyano)thiophene copolymers
Synthesis Reference(s)
The Journal of Organic Chemistry, 44, p. 1670, 1979 DOI: 10.1021/jo01324a019
Synthetic Communications, 20, p. 3153, 1990 DOI: 10.1080/00397919008051539
Synthesis
498-62-4
1641-09-4
General procedure for the synthesis of 3-cyanothiophene from 3-thiophenecarboxaldehyde: A mixture of 3-thiophenecarboxaldehyde (1.0 mmol), NH2OH-HCl (1.5 mmol), and Cog-C3N4 (20 mg) in H2O/MeOH (1:1, 5 mL) was added to a round-bottomed flask and the reaction was stirred for 14-20 h at room temperature under visible-light irradiation. The reaction progress was monitored by TLC. After completion of the reaction, the catalyst was removed by filtration and the filtrate was extracted by adding EtOAc (10 mL) to the filtrate. The organic layer was separated and washed sequentially with brine (2 x 5 mL) and distilled water (1 x 10 mL) and then dried with anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was further purified by fast column chromatography with the eluent ratio of EtOAc/hexane (10:90) to obtain analytically pure 3-cyanothiophene.
References
[1] Organic Letters, 2017, vol. 19, # 11, p. 3005 - 3008
[2] Catalysis Communications, 2019, p. 76 - 81
[3] Journal of Polymer Science, Part A: Polymer Chemistry, 2014, vol. 52, # 8, p. 1055 - 1058
[4] Tetrahedron Letters, 2012, vol. 53, # 7, p. 882 - 885
[5] Chemical Communications, 2013, vol. 49, # 54, p. 6030 - 6032
3-Thiophenecarbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Thiophenecarbonitrile manufacturers
- Product
- 3-Thiophenecarbonitrile 1641-09-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 2000
- Release date
- 2025-04-18
- Product
- 3-Thiophenecarbonitrile 1641-09-4
- Price
- US $1786.00/Kg
- Min. Order
- 1Kg
- Purity
- 99 %
- Supply Ability
- 1000 Kg
- Release date
- 2024-11-12
- Product
- 3-Thiophenecarbonitrile 1641-09-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-08-05