ChemicalBook > CAS DataBase List > 3-Thiophenecarbonitrile

3-Thiophenecarbonitrile

Product Name
3-Thiophenecarbonitrile
CAS No.
1641-09-4
Chemical Name
3-Thiophenecarbonitrile
Synonyms
THIOPHENE-3-CARBONITRILE;3-cyanothiophen;3-CYANOTHIOPHENE;BUTTPARK 96\11-31;3-Thiophenecarbonitr;3-Cyanothiophene >3-THIOPHENECARBONITRILE;Thiophen-3-carbonitrile;3-Thiophenecarbonitrile 95%;3-Thiophenecarbonitrile,94%
CBNumber
CB3245804
Molecular Formula
C5H3NS
Formula Weight
109.15
MOL File
1641-09-4.mol
More
Less

3-Thiophenecarbonitrile Property

Boiling point:
82 °C10 mm Hg(lit.)
Density 
1.2 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.5630(lit.)
Flash point:
186 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
Liquid
Specific Gravity
1.2
color 
Clear colorless
BRN 
107104
CAS DataBase Reference
1641-09-4(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36-36/37
RIDADR 
3276
WGK Germany 
3
Hazard Note 
Harmful
HazardClass 
6.1
PackingGroup 
III
HS Code 
29341000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
597449
Product name
3-Thiophenecarbonitrile
Purity
95%
Packaging
5g
Price
$36.7
Updated
2025/07/31
Sigma-Aldrich
Product number
597449
Product name
3-Thiophenecarbonitrile
Purity
95%
Packaging
25g
Price
$156
Updated
2025/07/31
TCI Chemical
Product number
C1344
Product name
3-Cyanothiophene
Purity
>98.0%(GC)
Packaging
5g
Price
$48
Updated
2025/07/31
TCI Chemical
Product number
C1344
Product name
3-Cyanothiophene
Purity
>98.0%(GC)
Packaging
25g
Price
$192
Updated
2025/07/31
TRC
Product number
C982320
Product name
3-Cyanothiophene
Packaging
50mg
Price
$45
Updated
2021/12/16
More
Less

3-Thiophenecarbonitrile Chemical Properties,Usage,Production

Chemical Properties

Clear colorless liquid

Uses

3-Thiophenecarbonitrile can be used to synthesize the following:

  • 2,4-dinaphthyl-3-cyanothiophene via reaction with iodonaphthalene
  • 2,5-bis-tri(n-butyl)tin-3-cyanothiophene, a building block for the synthesis of new alternating (3-alkyl/3-cyano)thiophene copolymers

Synthesis Reference(s)

The Journal of Organic Chemistry, 44, p. 1670, 1979 DOI: 10.1021/jo01324a019
Synthetic Communications, 20, p. 3153, 1990 DOI: 10.1080/00397919008051539

Synthesis

498-62-4

1641-09-4

General procedure for the synthesis of 3-cyanothiophene from 3-thiophenecarboxaldehyde: A mixture of 3-thiophenecarboxaldehyde (1.0 mmol), NH2OH-HCl (1.5 mmol), and Cog-C3N4 (20 mg) in H2O/MeOH (1:1, 5 mL) was added to a round-bottomed flask and the reaction was stirred for 14-20 h at room temperature under visible-light irradiation. The reaction progress was monitored by TLC. After completion of the reaction, the catalyst was removed by filtration and the filtrate was extracted by adding EtOAc (10 mL) to the filtrate. The organic layer was separated and washed sequentially with brine (2 x 5 mL) and distilled water (1 x 10 mL) and then dried with anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was further purified by fast column chromatography with the eluent ratio of EtOAc/hexane (10:90) to obtain analytically pure 3-cyanothiophene.

References

[1] Organic Letters, 2017, vol. 19, # 11, p. 3005 - 3008
[2] Catalysis Communications, 2019, p. 76 - 81
[3] Journal of Polymer Science, Part A: Polymer Chemistry, 2014, vol. 52, # 8, p. 1055 - 1058
[4] Tetrahedron Letters, 2012, vol. 53, # 7, p. 882 - 885
[5] Chemical Communications, 2013, vol. 49, # 54, p. 6030 - 6032

3-Thiophenecarbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

3-Thiophenecarbonitrile Suppliers

Americas 1 Belgium 3 Canada 1 CHINA 143 Europe 3 France 1 Germany 8 India 19 Japan 4 Slovakia 1 Switzerland 3 United Kingdom 22 United States 42 Global 251
Alfa Chemistry
Tel
+1-5166625404;
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
20405
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
SynQuest Laboratories, Inc. (Part of Central Glass Co., Ltd.)
Tel
--
Fax
--
Email
nfo@synquestlabs.com
Country
United States
ProdList
1897
Advantage
58
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United States
ProdList
4583
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
TCI America, Inc. (Tokyo Chemical Industry Co., Ltd.)
Tel
--
Fax
--
Email
.Crew@tcichemicals.com
Country
United States
ProdList
3164
Advantage
58
AstaTech, Inc.
Tel
--
Fax
--
Email
sales@astatechinc.com
Country
United States
ProdList
904
Advantage
58
Parchem Fine & Specialty Chemicals
Tel
--
Fax
--
Email
info@parchem.com
Country
United States
ProdList
1031
Advantage
58
Combi-Blocks, Inc.
Tel
--
Fax
--
Email
les@combi-blocks.com
Country
United States
ProdList
2555
Advantage
58
Brightek LLC
Tel
--
Fax
--
Country
United States
ProdList
782
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
Wilshire Technologies, Inc.
Tel
--
Fax
--
Email
info@wilshiretechnologies.com
Country
United States
ProdList
893
Advantage
58
SynQuest Laboratories, Inc.,
Tel
--
Fax
--
Country
United States
ProdList
2301
Advantage
58
Wilshire Technologies
Tel
--
Fax
--
Country
United States
ProdList
428
Advantage
58
Pennbio Chemicals (U.S.A.)
Tel
--
Fax
--
Country
United States
ProdList
240
Advantage
58
QV Chemicals LLC
Tel
--
Fax
--
Email
info@qvchemicals.com
Country
United States
ProdList
257
Advantage
50
VWR International, LLC.
Tel
--
Fax
--
Email
@sargentwelch.com
Country
United States
ProdList
6262
Advantage
58
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Sphinx Scientific Laboratory, LLC
Tel
--
Fax
--
Email
sales@sphinxscientificlab.com
Country
United States
ProdList
3343
Advantage
50
Wilshire Chemical Company Inc.
Tel
--
Fax
--
Email
WilshrChem@AOL.COM
Country
United States
ProdList
3498
Advantage
58
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
Ryan Scientific, Inc.
Tel
--
Fax
--
Email
ryan.reichlyn@ryansci.com
Country
United States
ProdList
6439
Advantage
60
AstaTech, Inc
Tel
--
Fax
--
Email
sales@astatechinc.com
Country
United States
ProdList
6371
Advantage
58
Focus Synthesis LLC
Tel
--
Fax
--
Email
acd@focussynthesis.com
Country
United States
ProdList
2487
Advantage
61
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
ChemContract Research Inc.
Tel
--
Fax
--
Country
United States
ProdList
1526
Advantage
38
Aagami, Inc.
Tel
--
Fax
--
Email
dinesh@aagami.net
Country
United States
ProdList
557
Advantage
42
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
More
Less

View Lastest Price from 3-Thiophenecarbonitrile manufacturers

Shenzhen Nexcon Pharmatechs Ltd.
Product
3-Thiophenecarbonitrile 1641-09-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
2000
Release date
2025-04-18
R&D Scientific Inc.
Product
3-Thiophenecarbonitrile 1641-09-4
Price
US $1786.00/Kg
Min. Order
1Kg
Purity
99 %
Supply Ability
1000 Kg
Release date
2024-11-12
Career Henan Chemical Co
Product
3-Thiophenecarbonitrile 1641-09-4
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
150KG
Release date
2019-08-05

1641-09-4, 3-ThiophenecarbonitrileRelated Search:

Tetrahydrothiophene ETHYL 2-CYANOACRYLATE Benzonitrile Methylene dithiocyanate Cyanoacetic acid Thifensulfuron Thiophene Thifensulfuron methyl Poly(3-hexylthiophene-2,5-diyl) Cephalothin sodium Sodium cyanoborohydride 4-Nitrobenzonitrile 2-NITROTHIOPHENE-4-CARBONITRILE N1-(3-CYANO-4-METHYL-2-THIENYL)-2-CHLOROACETAMIDE 2-AMINO-4,5-TRIMETHYLENE-3-THIOPHENECARBONITRILE METHYL 3-AMINO-4-CYANOTHIOPHENE-2-CARBOXYLATE 2-Thiophenecarbonitrile ETHYL 3-AMINO-4-CYANO-5-(METHYLTHIO)THIOPHENE-2-CARBOXYLATE

  • BUTTPARK 96\11-31
  • 3-CYANOTHIOPHENE
  • 3-THIOPHENECARBONITRILE
  • THIOPHENE-3-CARBONITRILE
  • Thiophene-3-carbonitrile 97%
  • 3-Thiophenecarbonitr
  • 3-Cyanothiophene, Thiophene-3-nitrile
  • 3-Thiophenecarbonitrile,94%
  • 3-cyanothiophen
  • 3-Thiophenecarbonitrile 95%
  • 3-thiophenecarbonitrile:3-cyanothiophene
  • 3-Cyanothiophene &gt
  • 3-Thiophenecarbonitrile ISO 9001：2015 REACH
  • 3-Thiophenecarbonitrile (6CI, 7CI, 8CI, 9CI, ACI)
  • Thiophen-3-carbonitrile
  • 1641-09-4
  • 1641-09-0
  • C5H3NS
  • Heterocyclic Building Blocks
  • Thiophenes
  • Thiophene Derivatives (for Conduting Polymer Research)
  • Reagents for Conducting Polymer Research
  • Building Blocks
  • Functional Materials
  • Reagents for Conducting Polymer Research
  • Thiophene Derivatives (for Conduting Polymer Research)
  • Thiophen
  • Sulphur Derivatives
  • Thiophene&Benzothiophene