ChemicalBook > CAS DataBase List > Losmapimod (GW856553X)

Losmapimod (GW856553X)

Product Name
Losmapimod (GW856553X)
CAS No.
585543-15-3
Chemical Name
Losmapimod (GW856553X)
Synonyms
CS-1186;GSK-AHAB;SB856553;GW-856553;LosMapiMod;GW 856553X;SB0856553);MIS-21394 LOSMAPIMOD;LosMapiMod,GW-856553;Losmapimod, W-856553
CBNumber
CB32484670
Molecular Formula
C22H26FN3O2
Formula Weight
383.46
MOL File
585543-15-3.mol
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Losmapimod (GW856553X) Property

Boiling point:
529.4±50.0 °C(Predicted)
Density 
1.20±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in EtOH; insoluble in H2O; ≥19.15 mg/mL in DMSO
form 
solid
pka
7.75±0.46(Predicted)
color 
White to off-white
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13614
Product name
GW 856553X
Purity
≥98%
Packaging
1mg
Price
$34
Updated
2024/03/01
Cayman Chemical
Product number
13614
Product name
GW 856553X
Purity
≥98%
Packaging
5mg
Price
$67
Updated
2024/03/01
Cayman Chemical
Product number
13614
Product name
GW 856553X
Purity
≥98%
Packaging
10mg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
13614
Product name
GW 856553X
Purity
≥98%
Packaging
25mg
Price
$249
Updated
2024/03/01
TRC
Product number
L471000
Product name
Losmapimod
Packaging
50mg
Price
$340
Updated
2021/12/16
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Losmapimod (GW856553X) Chemical Properties,Usage,Production

Description

GW 856553X is a dual inhibitor of p38α and p38β MAPK (Kis = 0.0079 and 0.025 μM, respectively, in cell-free assays). It is selective for p38α and p38β MAPK over p38γ and p38δ MAPK when used at a concentration of 10 μM. GW 856553X inhibits LPS-induced TNF-α production in isolated rat and human peripheral blood mononuclear cells (PBMCs; IC50s = 0.6 and 0.13 μM, respectively). It decreases disease severity in a mouse model of collagen-induced arthritis when administered at doses ranging from 0.8 to 20 mg/kg. GW 856553X (1.2 and 12 mg/kg) improves survival, normalizes blood pressure, and reduces increases in plasma levels of HDL, LDL, and triglycerides in spontaneously hypertensive stroke-prone rats fed a high-salt high-fat diet.

Uses

Losmapimod is a selective, potent, and orally active p38 MAPK inhibitor.

Definition

ChEBI: 6-[5-[(cyclopropylamino)-oxomethyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide is a phenylpyridine.

target

p38α

References

[1]. willette rn, eybye me, olzinski ar, et al. differential effects of p38 mitogen-activated protein kinase and cyclooxygenase 2 inhibitors in a model of cardiovascular disease. j pharmacol exp ther, 2009, 330(3): 964-970.
[2]. cheriyan j, webb aj, sarov-blat l, et al. inhibition of p38 mitogen-activated protein kinase improves nitric oxide-mediated vasodilatation and reduces inflammation in hypercholesterolemia. circulation., 2011, 123(5): 515-523.
[3]. lomas da, lipson da, miller be, et al. an oral inhibitor of p38 map kinase reduces plasma fibrinogen in patients with chronic obstructive pulmonary disease. j clin pharmacol, 2012, 52(3): 416-424.

Losmapimod (GW856553X) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Losmapimod (GW856553X) manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Losmapimod 585543-15-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Losmapimod 585543-15-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
Losmapimod (GW856553X) 585543-15-3
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
20kg
Release date
2019-12-23

585543-15-3, Losmapimod (GW856553X)Related Search:

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  • 6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide
  • GW-856553
  • GSK-AHAB
  • GW 856553X
  • LosMapiMod
  • LosMapiMod,GW-856553
  • Losmapimod (GW856553X)
  • 3-Pyridinecarboxamide, 6-[5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-
  • 6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide. Losmapimod,GW-856553
  • CS-1186
  • MIS-21394 LOSMAPIMOD
  • SB856553
  • Losmapimod (GW856553X) USP/EP/BP
  • Losmapimod (GW0856553X
  • SB0856553)
  • Losmapimod, W-856553
  • 585543-15-3
  • Inhibitors