2,2,6,6-Tetramethylpiperidinylmagnesium chloride lithium chloride complex
- Product Name
- 2,2,6,6-Tetramethylpiperidinylmagnesium chloride lithium chloride complex
- CAS No.
- 898838-07-8
- Chemical Name
- 2,2,6,6-Tetramethylpiperidinylmagnesium chloride lithium chloride complex
- Synonyms
- piperidinyL;2,2,6,6-Tetramethylpiperidinylmagnesium chloride lithium chloride;Magnesate(1-), dichloro(2,2,6,6-tetramethylpiperidinato)-, lithium (1:1);2,2,6,6-tetramethylpiperidin-1-ide;lithium,magnesium,2,2,6,6-tetramethylpiperidin-1-ide,dichloride;2,2,6,6-Tetramethylpiperidinylmagnesium chloride lithium chloride complex solution;TMPMgCl·LiCl;2,2,6,6-tetramethylpiperidinato)magnesate lithium;2,2,6,6-Tetramethylpiperidinylmagnesium chloride l;2,2,6,6-Tetramethylpiperidinylmagnesium chloride lithium chl
- CBNumber
- CB32489918
- Molecular Formula
- C9H18Cl2LiMgN
- Formula Weight
- 242.4
- MOL File
- 898838-07-8.mol
2,2,6,6-Tetramethylpiperidinylmagnesium chloride lithium chloride complex Property
- Boiling point:
- 66°/759.8mm
- Density
- 0.96g/mLat 25℃
- Flash point:
- -15°C
- storage temp.
- 2-8°C
- form
- liquid
- InChI
- InChI=1S/C9H18N.2ClH.Li.Mg/c1-8(2)6-5-7-9(3,4)10-8;;;;/h5-7H2,1-4H3;2*1H;;/q-1;;;+1;+2/p-2
- InChIKey
- JHBZAAACZVPPRQ-UHFFFAOYSA-L
- SMILES
- [Mg+2]([N-]1C(CCCC1(C)C)(C)C)([Cl-])[Cl-].[Li+]
Safety
- Hazard Codes
- F,C
- Risk Statements
- 63-11-14-19-34-37-40
- Safety Statements
- 16-26-36/37/39-45
- RIDADR
- UN 3399 4.3/PG 1
- WGK Germany
- 3
- HazardClass
- 3, 8
- HS Code
- 29333990
- Storage Class
- 4.3 - Hazardous materials which set free flammable gases upon contact with water
- Hazard Classifications
- Carc. 2
Eye Dam. 1
Flam. Liq. 2
Repr. 2
Skin Corr. 1B
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
H335May cause respiratory irritation
H351Suspected of causing cancer
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
N-Bromosuccinimide Price
- Product number
- 703540
- Product name
- 2,2,6,6-Tetramethylpiperidinylmagnesium chloride lithium chloride complex solution
- Purity
- 1.0 M in THF/toluene
- Packaging
- 4x25ml
- Price
- $190
- Updated
- 2025/07/31
- Product number
- 703540
- Product name
- 2,2,6,6-Tetramethylpiperidinylmagnesium chloride lithium chloride complex solution
- Purity
- 1.0 M in THF/toluene
- Packaging
- 100ml
- Price
- $223
- Updated
- 2025/07/31
- Product number
- 703540
- Product name
- 2,2,6,6-Tetramethylpiperidinylmagnesium chloride lithium chloride complex solution
- Purity
- 1.0 M in THF/toluene
- Packaging
- 500ml
- Price
- $689
- Updated
- 2025/07/31
2,2,6,6-Tetramethylpiperidinylmagnesium chloride lithium chloride complex Chemical Properties,Usage,Production
Uses
2,2,6,6-Tetramethylpiperidinylmagnesium Chloride Lithium Chloride Complex is used in preparation of Pyridazinones as herbicides. Also, used in preparation of MCL-1 inhibitors useful for treatment of cancer.
Uses
2,2,6,6-Tetramethylpiperidinylmagnesium chloride lithium chloride complex is a non-nucleophilic Knochel-Hauser base mainly used for the magnesiation of functionalized arenes and heteroarenes to prepare the corresponding Grignard reagents. It can also be used as a base in the synthesis of Π-conjugated polymers via catalyst-transfer polycondensation.
Uses
2,2,6,6-Tetramethylpiperidinylmagnesium chloride lithium chloride complex deprotonations using Knochel-Hauser-Base
reaction suitability
reaction type: Grignard Reaction
Synthesis
A 1000-ml triple-necked flask was taken, and the reaction flask was replaced three times with argon, and a little argon was turned on after the replacement so that the triple-necked flask was in an argon atmosphere, and then anhydrous lithium chloride (42.4 g, (1 mol), 2,2,6,6-tetramethylpiperidine (141.3 g, 1 mol), and 1,10-phenanthroline (0.54 g, 3 mmol) were then added to the triplex, and 150 mL of tetrahydrofuran was added, and the temperature was controlled to 0-5 C, and the mixture was stirred for 10 min, then a dropwise concentration of was added. Degree of 2.0 M of isopropylmagnesium chloride of tetrahydrofuran solution (500 mL, 1 mol), dropwise addition process to control the temperature does not exceed 10 C. After the dropwise addition is completed, increase the temperature to 20-25 C, and continue to stir for 8 hours, the reaction is completed, the holding at room temperature to settle for about 2 hours, filtered through a sand plate funnel, and washed by the tetrahydrofuran, to obtain the concentration of 1.3 M of magnesium dichloride (2,2,6,6 -tetramethylpiperidine) lithium salt of tetrahydrofuran solution 692mL (90% yield).
2,2,6,6-Tetramethylpiperidinylmagnesium chloride lithium chloride complex Preparation Products And Raw materials
Raw materials
Preparation Products
2,2,6,6-Tetramethylpiperidinylmagnesium chloride lithium chloride complex Suppliers
- Tel
- 021-021-50400622 15618790390
- info@chemart.cn
- Country
- China
- ProdList
- 238
- Advantage
- 58
- Tel
- 15901742157
- 609923428@qq.com
- Country
- China
- ProdList
- 69
- Advantage
- 58
- Tel
- 15021941186
- 3572772243@qq.com
- Country
- China
- ProdList
- 157
- Advantage
- 58
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44802
- Advantage
- 61
- Tel
- 010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 11776
- Advantage
- 60
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9309
- Advantage
- 66
- Tel
- 025-85760892 13376080562
- Fax
- 025-85766769
- sales@habotech.com
- Country
- China
- ProdList
- 890
- Advantage
- 60
- Tel
- 025-83697070 13913916777;
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15724
- Advantage
- 64
- Tel
- 15693160370; 15693160393
- Fax
- 028-37690518
- lzhschemical@163.com
- Country
- China
- ProdList
- 58
- Advantage
- 58
- Tel
- +86-02150456736 +86-18602143071
- Fax
- 021-50761379
- xin@riyngroup.com
- Country
- China
- ProdList
- 500
- Advantage
- 30