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Darunavir ethanolate

Product Name
Darunavir ethanolate
CAS No.
635728-49-3
Chemical Name
Darunavir ethanolate
Synonyms
Darunavir ethanolate;Carbamic acid, ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-, (3R,3as,6ar)-hexahydrofuro(2,3-B)furan-3-yl ester, compd. with ethanol (1:1);To the drug;Unii-33o78xf0bw;[14C]-Darunavir ethanolate;Darunavir Ethanolate (100 mg);Darunavir Ethanolate(Prezista);Darunavir Ethanolate (DRV, Prezista);DARUNAVIR ETHANOLATE (TMC114 ETHANOLATE);Darunavir(TMC-114,UIC 94017) Ethanolate
CBNumber
CB32496602
Molecular Formula
C29H43N3O8S
Formula Weight
593.74
MOL File
635728-49-3.mol
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Darunavir ethanolate Property

Melting point:
98-100°C
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
color 
White
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Safety

HS Code 
29334900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D193520
Product name
DarunavirEthanolate
Packaging
5mg
Price
$150
Updated
2021/12/16
Usbiological
Product number
163597
Product name
Darunavir Ethanolate
Packaging
5mg
Price
$460
Updated
2021/12/16
TRC
Product number
D193520
Product name
DarunavirEthanolate
Packaging
50mg
Price
$770
Updated
2021/12/16
ChemScene
Product number
CS-0750
Product name
DarunavirEthanolate
Purity
99.92%
Packaging
100mg
Price
$500
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD64995
Product name
Darunavir Ethanolate
Packaging
500mg
Price
$175
Updated
2021/12/16
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Darunavir ethanolate Chemical Properties,Usage,Production

Uses

Darunavir Ethanolate(Prezista) is an inhibitor of HIV protease. [1] Darunavir was designed to form robust interactions with the protease enzyme from many strains of HIV, including strains from treatment-experienced patients with multiple resistance mutati

Uses

Darunavir Ethanolate (Prezista) is an HIV protease inhibitor. Derivative of Darunavir (D193500), a second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.

Biological Activity

darunavir ethanolate is a nonpeptidic hiv protease inhibitor approved for the treatment of hiv infection[1].transepithelial transport of darunavir in caco-2 cell monolayers is 2-fold greater in the basal-to-apical direction compared to that in the opposite direction. in l-mdr1 cell, darunavir (121 mm) inhibits p-glycoprotein-mediated efflux of calcein-acetoxymethyl ester[1].darunavir is effective against wild-type and pi-resistant hiv, and has a low oral bioavailability (37%). when used in combination with ritonavir, bioavailability can be increased to 82%[2].[1]. fujimoto h, higuchi m, watanabe h, et al. p-glycoprotein mediates efflux transport of darunavir in human intestinal caco-2 and abcb1 gene-transfected renal llc-pk1 cell lines. biological & pharmaceutical bulletin, 2009, 32(9): 1588-1593.[2]. bhalekar mr, et al. in-vivo bioavailability and lymphatic uptake evaluation of lipid nanoparticulates of darunavir. drug deliv, 2016, 23(7): 2581-2586.

Darunavir ethanolate Preparation Products And Raw materials

Raw materials

Preparation Products

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Darunavir ethanolate Suppliers

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View Lastest Price from Darunavir ethanolate manufacturers

Sinoway Industrial co., ltd.
Product
Darunavir ethanolate 635728-49-3
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
0.0099
Supply Ability
20 tons
Release date
2021-08-05
Baoji Guokang Bio-Technology Co., Ltd.
Product
Unii-33o78xf0bw 635728-49-3
Price
US $63.00/g
Min. Order
1g
Purity
98%
Supply Ability
100kg
Release date
2021-06-04
Zhuozhou Wenxi import and Export Co., Ltd
Product
Unii-33o78xf0bw 635728-49-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

635728-49-3, Darunavir ethanolateRelated Search:

1-epi-Darunavir (3aS,4R,6aR)-Tetrahydro-4-Methoxyfuro[3,4-b]furan-2(3H)-one BIS THF Nitro Derivative 2 Darunavir O-β-D-Glucuronide BIS THF HNS Derivative 3 Repaglinide Pazopanib Hydrochloride 4-Hydroxy Darunavir [(3R,3aS,6aR)-Hydroxyhexahydrofuro[2,3-β]furanyl Succinimidyl Carbonate tert-Butyl [(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl[(4-nitrophenyl)sulfonyl]amino]propyl]carbamate Darunavir (3R,3αS,6αR)-Hexahydrofuro[2,3-β]furan-3-yl-4-nitrophenyl carbonate 4-AMINO-N-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]-N-ISOBUTYLBENZENE-1-SULFONAMIDE 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile GSK1349572 Raltegravir Etravirine Atazanavir sulfate

  • Carbamic acid, ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-, (3R,3as,6ar)-hexahydrofuro(2,3-B)furan-3-yl ester, compd. with ethanol (1:1)
  • Darunavir ethanolate
  • Unii-33o78xf0bw
  • N-[(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester compd. with ethanol
  • Darunavir Ethanolate(Prezista)
  • Darunavir(TMC-114,UIC 94017) Ethanolate
  • N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl carbamic acid ester, compd. with ethanol (1:1)
  • (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate compound with ethanol (1:1)
  • [14C]-Darunavir ethanolate
  • DARUNAVIR ETHANOLATE (TMC114 ETHANOLATE)
  • Darunavir Ethanolate (DRV, Prezista)
  • Darunavir EthanolateQ: What is Darunavir Ethanolate Q: What is the CAS Number of Darunavir Ethanolate Q: What is the storage condition of Darunavir Ethanolate Q: What are the applications of Darunavir Ethanolate
  • To the drug
  • (3R,3AS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate Ethanolate
  • Darunavir Ethanolate (100 mg)
  • 635728-49-3
  • 20661-99-1
  • C29H43N3O8S
  • C27H37N3O7SC2H6O
  • C27H37N3O7SC2H5OH
  • API
  • Inhibitor
  • Prezista, TMC114
  • Other APIs
  • Inhibitors