Morachalcone A
- Product Name
- Morachalcone A
- CAS No.
- 76472-88-3
- Chemical Name
- Morachalcone A
- Synonyms
- Morachalcone A;(2E)-1-[2,4-Dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(2,4-dihydroxyphenyl)-2-propen-1-one;2-Propen-1-one, 1-[2,4-dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(2,4-dihydroxyphenyl)-, (2E)-
- CBNumber
- CB32519875
- Molecular Formula
- C20H20O5
- Formula Weight
- 340.37
- MOL File
- 76472-88-3.mol
Morachalcone A Property
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- powder
- color
- Yellow
N-Bromosuccinimide Price
- Product number
- AS027751
- Product name
- MorachalconeA
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $339
- Updated
- 2021/12/16
- Product number
- CFN97241
- Product name
- MorachalconeA
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $553
- Updated
- 2021/12/16
- Product number
- CD32000467
- Product name
- MorachalconeA
- Purity
- 95+%
- Packaging
- 5mg
- Price
- $852
- Updated
- 2021/12/16
Morachalcone A Chemical Properties,Usage,Production
Description
Morachalcone A exhibits neuroprotective effects on HT22-immortalized hippocampal cells against glutamate-induced oxidative stress, with EC50 values of 35.5±1 uM. Morachalcone A exhibits potent inhibitory activity on nitric oxide production in RAW264.7 LPS-activated mouse macrophage cells with IC50 value of 16.4 microM. 3. Morachalcone A displays significant tyrosinase inhibitory activity (IC50, 0.013 uM). 4. Morachalcone A exerts strong pancreatic lipase inhibition with IC 50 value of 6.2 uM.
Uses
Morachalcone A is a naturally-occurring aromatase inhibitor (IC50=4.6 mM). Morachalcone A is also a plants metabolite with potential anti-inflammatory and anticancer activity. Morachalcone A inhibits Lipopolysaccharide (HY-D1056)-induced nitric oxide production[1][2][3].
Definition
ChEBI: Morachalcone A is a member of chalcones.
target
Tyrosinase | NO
References
[1] Brandt D R, et al. The synthetic preparation of naturally-occurring aromatase inhibitors, morachalcone A, isogemichalcone B, and isogemichalcone C[J]. Tetrahedron, 2013, 69(47): 9994-10002.
[2] Kang Y J, et al. Inhibitory effects of morachalcone A on lipopolysaccharide-induced nitric oxide production in raw 264.7 cells[J]. 2009.
[3] Ferlinahayati, et al. Phenolic constituents from the wood of Morus australis with cytotoxic activity. Z Naturforsch C J Biosci. 2008 Jan-Feb;63(1-2):35-9. DOI:10.1515/znc-2008-1-207
Morachalcone A Preparation Products And Raw materials
Raw materials
Preparation Products
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