3-Hydroxyphthalic anhydride
- Product Name
- 3-Hydroxyphthalic anhydride
- CAS No.
- 37418-88-5
- Chemical Name
- 3-Hydroxyphthalic anhydride
- Synonyms
- 4-HYDROXY-ISOBENZOFURAN-1,3-DIONE;Nsc 80858;Brn 0135783;3-HydroxyphthaL;3-hydroxy-phthalicanhydrid;3-hydroxyphtalic anhydride;3-HYDROXYPHTHALIC ANHYDRIDE;Phthalic anhydride, 3-hydroxy-;4-hydroxy-3-isobenzofurandione;3-HYDROXYPHTHALIC ACID ANHYDRIDE
- CBNumber
- CB3253702
- Molecular Formula
- C8H4O4
- Formula Weight
- 164.12
- MOL File
- 37418-88-5.mol
3-Hydroxyphthalic anhydride Property
- Melting point:
- 199-202 °C (lit.)
- Boiling point:
- 365.4±25.0 °C(Predicted)
- Density
- 1.624±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Acetonitrile (Slightly), DMSO (Slightly)
- pka
- 6.25±0.20(Predicted)
- form
- Powder
- color
- White to beige
- BRN
- 135783
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C8H4O4/c9-5-3-1-2-4-6(5)8(11)12-7(4)10/h1-3,9H
- InChIKey
- CCTOEAMRIIXGDJ-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C(O)=CC=C2)C(=O)O1
- CAS DataBase Reference
- 37418-88-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 308021
- Product name
- 3-Hydroxyphthalic anhydride
- Purity
- 98%
- Packaging
- 1g
- Price
- $120.4
- Updated
- 2024/03/01
- Product number
- H951270
- Product name
- 3-Hydroxyphthalic anhydride
- Packaging
- 2.5g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 2H26-1-33
- Product name
- 3-Hydroxyphthalic anhydride
- Purity
- 97%
- Packaging
- 5G
- Price
- $109
- Updated
- 2021/12/16
- Product number
- 222694
- Product name
- 4-Hydroxyisobenzofuran-1,3-dione
- Packaging
- 250mg
- Price
- $20
- Updated
- 2021/12/16
- Product number
- BP-13154
- Product name
- 3-Hydroxyphthalic anhydride
- Purity
- 98%
- Packaging
- 250mg
- Price
- $35
- Updated
- 2021/12/16
3-Hydroxyphthalic anhydride Chemical Properties,Usage,Production
Description
3-Hydroxyphthalic anhydride: a valuable raw material for chemical industry and pharmaceutical research.
Phthalic anhydride derivatives have been applied as plasticizers and heat-resistant polymers in the chemical industry. One of its derivatives is the 3-hydroxyphthalic anhydride (3-HPA), which exhibits a hydroxyl group substituent in position 3. 3-Hydroxyphthalic anhydride can be used as raw material for heat-resistant resins such as epoxy resins, polyesters, polyimides, etc., or as raw material for physiologically active substances such as medicines and pesticides. It has been shown that 3-HPA can serve as a raw material to obtain drugs with potential applications, such as anticancer, antimicrobial and in treating diabetes, herpes, and HIV[1].
Chemical Properties
Beige powder
Uses
3-Hydroxyphthalic Anhydride is used to synthesize 3-Hydroxyphthalic Anhydride-modified human serum albumin whichhas high potency as a microbicide for prevention of the sexual transmission of HIV. It is also used as a reagent in organicsynthesis of other compounds including that of inhibitors of NF-κB derived from thalidomide.
Synthesis Reference(s)
Journal of the American Chemical Society, 77, p. 5092, 1955 DOI: 10.1021/ja01624a042
Synthesis, p. 788, 1985 DOI: 10.1055/s-1985-31350
Synthesis
In the presence of triethylamine, the 2-oxo-2, 5-dihydrofuran, and pivaloyl chloride reactions generate 2-valeryl oxo furans. The affixture with 2-valeryl oxo furans and maleic anhydride uses vitriolization, which thereby generates the method of 3-hydroxyl phthalic anhydride.
References
[1] M. López-Ortega. “Standard enthalpies of formation of 3-hydroxyphthalic anhydride.” Revista Mexicana De Fisica (2022).
3-Hydroxyphthalic anhydride Preparation Products And Raw materials
Raw materials
Preparation Products
3-Hydroxyphthalic anhydride Suppliers
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- --
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- sales21@chemicalland21.com
- Country
- South Korea
- ProdList
- 6303
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View Lastest Price from 3-Hydroxyphthalic anhydride manufacturers
- Product
- 3-Hydroxyphthalic anhydride 37418-88-5
- Price
- US $125.58/Kg/Drum
- Min. Order
- 25Kg/Drum
- Purity
- 98.00%HPLC
- Supply Ability
- 1ton/month
- Release date
- 2021-09-17
- Product
- 3-Hydroxyphthalic anhydride 37418-88-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.01kg
- Purity
- 0.98
- Supply Ability
- 2 tons
- Release date
- 2024-11-15
- Product
- 3-HYDROXYPHTHALIC ANHYDRIDE 37418-88-5
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-19