2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine

Product Name: 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine
CAS No.: 934524-10-4
Chemical Name: 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine
Synonyms: ,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine;2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine;2,4-Dichloro-7-(p-tolylsulfonyl)pyrrolo[2,3-d]pyrimidine;2,4-dichloro-7-(4-methylphenyl)sulfonylpyrrolo[2,3-d]pyrimidine;2,4-Dichloro-7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyriMidine;2,4-dichloro-7-(4-methylbenzenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine;2,4-Dichloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine;7H-Pyrrolo[2,3-d]pyriMidine, 2,4-dichloro-7-[(4-Methylphenyl)sulfonyl]-;2,4-Dichloro-7-p-Methylbenzenesulfonyl-7H-Pyrrole[2,3-d]Pyrimidin-4-Amine
CBNumber: CB32550243
Molecular Formula: C13H9Cl2N3O2S
Formula Weight: 342.2
MOL File: 934524-10-4.mol

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2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine Property

Melting point:: 163-164°
Boiling point:: 447.1±55.0 °C(Predicted)
Density: 1.59
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 0.47±0.30(Predicted)
Appearance: Off-white to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B419308
Product name: 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B419308
Product name: 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD144057
Product name: 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
Packaging: 250mg
Price: $77.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD144057
Product name: 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
Packaging: 500mg
Price: $135
Updated: 2021/12/16

Matrix Scientific

Product number: 073810
Product name: 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
Purity: 95+%
Packaging: 250mg
Price: $231
Updated: 2021/12/16

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2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine Chemical Properties,Usage,Production

Synthesis

90213-66-4

98-59-9

934524-10-4

Using 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (1.00 g, 5.32 mmol) and p-toluenesulfonyl chloride (1.115 g, 5.85 mmol) as the raw materials, the two were dissolved in dichloromethane (20 mL) along with tetrabutylammonium hydrogen sulfate (0.090 g, 0.27 mmol) at room temperature. Subsequently, 50% aqueous sodium hydroxide solution (1 mL) was added to the reaction mixture and stirred at room temperature for 30 min. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction mixture was diluted with deionized water and dichloromethane and the organic layer was separated. The organic layer was concentrated by vacuum evaporation to give a light yellow solid. The crude product was purified by column chromatography (100% dichloromethane as eluent) to afford the target product 2,4-dichloro-7-toluenesulfonyl-7H-pyrrolo[2,3-d]pyrimidine (1.76 g, 97% yield) as a white solid. The mass spectrum (LCMS) showed [M + H]+ m/z 342. 1H NMR (400 MHz, chloroform-d) δ ppm: 8.14 (d, J = 8.59 Hz, 2H), 7.78 (d, J = 3.79 Hz, 1H), 7.39 (d, J = 8.59 Hz, 2H), 6.70 (d, J = 3.79 Hz, 1H). 2.45 (s, 3H).

References

[1] Patent: WO2010/38060, 2010, A1. Location in patent: Page/Page column 68-69
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 1, p. 144 - 158
[3] Patent: WO2010/123919, 2010, A2. Location in patent: Page/Page column 55
[4] Patent: WO2017/106771, 2017, A1. Location in patent: Paragraph 00397
[5] Patent: WO2017/133667, 2017, A1. Location in patent: Page/Page column 400

2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine Suppliers

China 90 Germany 1 India 2 United Kingdom 2 United States 7 Global 102

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View Lastest Price from 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine manufacturers

Career Henan Chemical Co

Product: ,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine 934524-10-4
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: ask
Release date: 2020-01-08

934524-10-4, 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidineRelated Search:

2,4-DIFLUOROPYRIMIDINE 3-(BOC-AMINO)-4-PICOLINE 3-((3S,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino) piperidin-1-yl)-3-oxopropanenitrile citric acid tert-butyl methyl((3R,4R)-4-methyl-1-tosylpiperidin-3-yl)carbamate N-((3SR,4RS)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (3RS,4SR)-methyl 1-benzyl-4-methylpiperidin-3-ylcarbamate ((3R,4R)-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 4-Methyl-piperidin-3-ol 4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE (3SR,4SR)-1-benzyl-N,4-dimethylpiperidin-3-amine (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride 3-((3RS,4RS)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino) piperidin-1-yl)-3-oxopropanenitrile citric acid ((3SR,4RS-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 2-Chloro-3,7-dihydro-4H-pyrrolo[2,3-d]pyriMidin-4-one Tofacitinib (3R,4R)-N,4-dimethyl-1-tosylpiperidin-3-amine N-((3RS,4RS)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (3RS,4SR)-1-benzyl-N-methyl-4-methylpiperidin-3-amine bis-(hydrochloride)

2,4-Dichloro-7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyriMidine

7H-Pyrrolo[2,3-d]pyriMidine, 2,4-dichloro-7-[(4-Methylphenyl)sulfonyl]-

2,4-Dichloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine

2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine

2,4-dichloro-7-(4-methylphenyl)sulfonylpyrrolo[2,3-d]pyrimidine

2,4-dichloro-7-(4-methylbenzenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine

,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine

2,4-Dichloro-7-(p-tolylsulfonyl)pyrrolo[2,3-d]pyrimidine

2,4-Dichloro-7-p-Methylbenzenesulfonyl-7H-Pyrrole[2,3-d]Pyrimidin-4-Amine

934524-10-4

Heterocycle-Pyrimidine series