HOAt

Product Name: HOAt
CAS No.: 39968-33-7
Chemical Name: HOAt
Synonyms: 1-Hydroxy-7-azabenzotriazole;HO-EPCP;[1,2,3]Triazolo[4,5-b]pyridin-3-ol;N-Hydroxy-7-azobenzotriazole;1-Hydroxy-7-azabenzotriazole (HOAt);HOAT;3]Triazolo[4;HOAt USP/EP/BP;5-b]pyridin-3-ol;HOAt - 0.6M in DMF
CBNumber: CB3256884
Molecular Formula: C5H4N4O
Formula Weight: 136.11
MOL File: 39968-33-7.mol

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HOAt Property

Melting point:: 213-216°C
Boiling point:: 250.36°C (rough estimate)
Density: 0.973 g/mL at 20 °C
refractive index: n20/D 1.441
Flash point:: 213-216°C
storage temp.: Store at RT.
solubility: >6.8mg/mL in DMSO
form: Powder
pka: 5.85±0.58(Predicted)
color: White to yellow
Decomposition: 213-216 ºC
InChI: InChI=1S/C5H4N4O/c10-9-5-4(7-8-9)2-1-3-6-5/h1-3,10H
InChIKey: FPIRBHDGWMWJEP-UHFFFAOYSA-N
SMILES: C12N(O)N=NC1=CC=CN=2
CAS DataBase Reference: 39968-33-7(CAS DataBase Reference)
EPA Substance Registry System: 3H-1,2,3-Triazolo[4,5-b]pyridine, 3-hydroxy- (39968-33-7)

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Safety

Hazard Codes: T,Xi,F,Xn,E
Risk Statements: 61-20/21-36-5-36/37/38-11-41-37/38-22-2-36/37
Safety Statements: 53-45-37/39-26-16-39-35-36-36/37-28-15
RIDADR: UN 1993 3/PG 3
WGK Germany: 1
HazardClass: IRRITANT
PackingGroup: Ⅱ
HS Code: 29332990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H204Fire or projection hazard

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P250Do not subject to grinding/shock/…/friction.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P370+P380in case of fire: Evacuate area.

P372Explosion risk in case of fire.

P373DO NOT fight fire when fire reaches explosives.

P374Fight fire with normal precautions from a reasonable distance.

P401Store …

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A7024
Product name: HOAt
Packaging: 10mM(in 1mL DMSO)
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-W019594
Product name: 1-Hydroxy-7-azabenzotriazole
Purity: 99.81%
Packaging: 25g
Price: $75
Updated: 2021/12/16

ApexBio Technology

Product number: A7024
Product name: HOAt
Packaging: 25g
Price: $77
Updated: 2021/12/16

ApexBio Technology

Product number: A7024
Product name: HOAt
Packaging: 100g
Price: $192
Updated: 2021/12/16

ChemScene

Product number: CS-W019594
Product name: 1-Hydroxy-7-azabenzotriazole
Purity: 99.81%
Packaging: 100g
Price: $225
Updated: 2021/12/16

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HOAt Chemical Properties,Usage,Production

Description

HOAt (also known as 1-Hydroxy-7-azabenzotriazole) is a benzotriazole compound commonly used as a coupling reagent for amino acids and peptides. HOAt is also used as a solid-phase synthesis reagent for chiral peptide nucleic acids.

Chemical Properties

Clear, colorless liquid

Uses

1-Hydroxy-7-azabenzotriazole can be used as antibacterial, anti-aging and flame-retardant dendritic polyacrylate emulsion.

Application

HOAt is a triazole derivative used in amide coupling chemistry as an additive in combination with coupling agents. The most used coupling reagents with HOAt are the carbodiimides EDCI, DCC and DIC. HOAt is comparable to HOBt but gives a better performance. It has faster reaction rates, reduced racemisation, higher yields and visual indication of the reaction endpoint by colour change of the reaction mixture from yellow to colourless. The increased efficiency of HOAt compared to HOBt is related to the stabilisation of the activated intermediate via anchimeric effect, due to the formation of a hydrogen bond with the N atom in position 7 of the benzotriazole. As is HOBt, HOAt is explosive and is therefore required to be handled carefully.

General Description

HOAt is a commonly used peptide bond forming agent that may become an impurity in drug synthesis, but is not mutagenic. HOAt can be used for peptide fragment polycondensation and can also inhibit the racemization of peptide polycondensation.

reaction suitability

reaction type: Addition Reactions

Precautions

3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridine is stable, not hygroscopic, and can be stored indefinitely. HOAt (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridine) solutions in DMF (0.3 M) can be stored in an inert atmosphere for weeks. Syntheses of peptides carried out with freshly prepared and 4-week-old solutions show similar quality to the crude product. Violent decomposition may occur when dried at elevated temperatures.

HOAt Preparation Products And Raw materials

Raw materials

Preparation Products

2-Ethylpiperazine

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HOAt Suppliers

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BTC pharm India

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View Lastest Price from HOAt manufacturers

Xinxiang Juyuan Biological Technology Co., Ltd.

Product: HOAT 39968-33-7
Price: US $5200.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 50tons
Release date: 2025-08-05

Henan Aochuang Chemical Co.,Ltd.

Product: HOAt 39968-33-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-26

PNP Biotech Co. Ltd

Product: 1-Hydroxy-7-azabenzotriazole 39968-33-7
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%
Supply Ability: Inquiry
Release date: 2022-09-16

39968-33-7, HOAtRelated Search:

1,2,3-1H-Triazole 1-Hydroxybenzotriazole 5-Methyl-1H-benzotriazole 1H-Benzotriazole 1,2,4-Triazole HATU N-CHLOROSACCHARIN 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride O-(6-Chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one HBTU 1-Hydroxybenzotriazole hydrate CHLOROPHOSPHONAZO III 2-(7-Azabenzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate N-Hydroxyphthalimide TBTU HOAt (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate

N-Hydroxy-7-azobenzotriazole

1-Hydroxy-7-azabenzo

3H-1,2,3-TRIAZOLO[4,5-B]PYRIDINE, 3-HYDROXY-

3H-[1,2,3]-TRIAZOLO[4,5-B]PYRIDIN-3-OL

7-AZA-1-HYDROXYBENZOTRIAZOLE

3H-[1,2,3]triazolo[4,5-b]pyridin-3-ol(SALTDATA: FREE)

7-Aza-1-hydroxybenzotriazole HOAt 1-Hydroxy-7-azabenzotriazole

N-Hydroxy-7-azabenzotriazole

3H-[1,2,3]Triazolo[4,5-b]pyridin-3-ol, 95+%

HOAT

1-Hydroxy-7-azabenotriazole

1-HYDROXY-7-AZABENZOTRIAZOLE 0.5 TO &

1-HYDROXY-7-AZABENZOTRIAZOLE SOLUTION, 0.5M IN DMF

HOAT [1-HYDROXY-7-AZABENZOTRIAZOLE]

1-Hydroxy-7-Azabenzotriazole99%Puriss

[1,2,3]Triazolo[4,5-b]pyridin-3-ol

1H-[1,2,3]triazolo[4,5-b]pyridine 3-Oxide

1-Hydroxy-7-azabenzotriazole solution

1-Hydroxy-7-azabenzotriazole (HOAt)

1-HYDROXY-7-AZABENZOTRIAZOL

HO-EPCP

3H-[1,2,3]-Triazolo[4,5-b]pyridin-3-ol, HOAt

1-Hydroxy-7-azabenzotriazole ,98%

3H-1,2,3-Triazolo[4,5-b]pyridin-3-ol [Peptide Coupling Additive]

1-Hydroxy-7-azabenzotriazole solution, 0.6 M in DMF

[1,2,3]Triazolo[4,5-β]pyridin-3-ol

1H-[1,2,3]triazolo[4,5-β]pyridine 3-Oxide

hoat（1－hydroxyl－7－azabenzotriazole）

1-Hydroxy-7-azabenzotriazole

1;2;3]TRIAZOLO[4;5-B]PYRIDIN-3-OL;1H-[1;2;3]TRIAZOLO[4;5-B]PYRIDINE 3-OXIDE;HOAT.

3]Triazolo[4

5-b]pyridin-3-ol

5-b]pyridine 3-Oxide

Olaparib Impurity 18 (HOAT)

Olaparib Impurity 23（HOAt）

Olaparib Impurity 47

HOAT 1-Hydroxy-7-azabenzotriazole,99%

HOAT 1M DMA solution

HOAt USP/EP/BP

39968-33-7/1-Hydroxy-7-azabenzotriazole

HOAT (1-Hydroxy-7-azobenzotriazole) pure, 98%

3-hydroxytriazolo[4,5-b]pyridine

1-Hydroxy-7-azabenzotriazole in DMA（1M)

1-Hydroxy-7-azabenzotriazole in DMF(0.6M/L）

HOAt - 0.6M in DMF

1-Hydroxy-7-azabenzotriazol, 0.6 M solution in DMF

1-Hydroxy-7-azabenzotriazole 1M DMA solution

1-HYDROXY-7-AZABENZOTRIAZOLE 99%min

39968-33-7

Synthetic Reagents

Coupling

Active Esters/Additives

Peptide Coupling Reagents

PROTECTED AMINO ACID & PEPTIDES

Heterocycles

Heterocyclic Compounds

Peptide

Bases & Related Reagents