L-Octahydroindole-2-carboxylic acid

Product Name: L-Octahydroindole-2-carboxylic acid
CAS No.: 80875-98-5
Chemical Name: L-Octahydroindole-2-carboxylic acid
Synonyms: (2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid;(2S,3aS,7aS)-Octahydro-2-indolecarboxylicacid;(2S,3αS,7αS)-Octahydro-1H-indole-2-carboxylic acid;(2R,3aR,7aR)-octahydro-1H-indole-2-carboxylic acid;L-Oic-OH;Perindopril Related Compound 7;OCTAHYDRO-INDOLE-2-CARBOXYLIC ACID;L-(2S,3aS,7aS)-Octahydroindole-2-carboxylic Acid;1H-Indole-2-carboxylicacid,octahydro-,(2S,3aS,7aS)-(9CI);Compound 80875-98-5
CBNumber: CB3258000
Molecular Formula: C9H15NO2
Formula Weight: 169.22
MOL File: 80875-98-5.mol

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L-Octahydroindole-2-carboxylic acid Property

Melting point:: 275-277°C
Boiling point:: 318.6±25.0 °C(Predicted)
Density: 1.135±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Methanol (Sparingly), Water (Slightly)
pka: 2.47±0.20(Predicted)
color: White to Off-White
PH: -50 (c=1 in methanol)
Water Solubility: Soluble in methanol and water.
InChI: InChI=1S/C9H15NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h6-8,10H,1-5H2,(H,11,12)/t6-,7-,8-/m0/s1
InChIKey: CQYBNXGHMBNGCG-FXQIFTODSA-N
SMILES: N1[C@]2([H])[C@@]([H])(CCCC2)C[C@H]1C(O)=O
LogP: 0.3 at 25℃ and pH5
CAS DataBase Reference: 80875-98-5(CAS DataBase Reference)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-37
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000237
Product name: Perindopril impurity A
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 15 mg
Price: $156
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHR3078
Product name: Perindopril Related Compound A
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 50MG
Price: $592
Updated: 2025/07/31

Sigma-Aldrich

Product number: Y0000237
Product name: Perindopril impurity A
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000237
Price: $153
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1510890
Product name: Perindopril Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 0
Price: $0
Updated: 2021/12/16

TCI Chemical

Product number: O0370
Product name: (2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $49
Updated: 2025/07/31

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L-Octahydroindole-2-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

An intermediate in the synthesis of Perindopril. Perindopril USP Related Compound A.

Synthesis

539820-41-2

80875-98-5

General procedure for the synthesis of L-octahydroindole-2-carboxylic acid from the compound (CAS: 539820-41-2): 200 g of the compound obtained in the previous step was dissolved in acetic acid, followed by the addition of 5 g of 10% Pt/C catalyst to the hydrogenator. The hydrogenation reaction was carried out at room temperature and 5 bar hydrogen pressure until a theoretical amount of hydrogen was absorbed. Upon completion of the reaction, the catalyst was removed by filtration and the resulting solid product was collected by filtration after the reaction solution was cooled to 0 to 5 °C. The reaction was carried out at room temperature and 5 bar hydrogen pressure. The filter cake was washed with a suitable solvent and dried under constant weight conditions. The final product was (2S,3aS,7aS)-octahydroindole-2-carboxylic acid in 87% yield and 99% enantiomeric purity.

References

[1] Patent: US2006/167273, 2006, A1. Location in patent: Page/Page column 2

L-Octahydroindole-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Perindopril

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L-Octahydroindole-2-carboxylic acid Suppliers

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View Lastest Price from L-Octahydroindole-2-carboxylic acid manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: L-Octahydroindole-2-Carboxylic Acid 80875-98-5
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-12-06

Baoji Guokang Healthchem Co., Ltd.

Product: L-Octahydroindole-2-carboxylic acid 80875-98-5
Price: US $793.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000KG
Release date: 2021-06-07

Hebei Chuanghai Biotechnology Co,.LTD

Product: L-Octahydroindole-2-Carboxylic Acid 80875-98-5
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-23

80875-98-5, L-Octahydroindole-2-carboxylic acidRelated Search:

Hyaluronic acid Indometacin cis-Octahydro-isoindole Indole-3-butyric acid Folic acid Indole-2-carboxylic acid Indole-3-acetic acid Ethyl 2-(Chlorosulfonyl)acetate Perindoprilat Ethyl L-octahydroindole-2-carboxylate hydrochloride (2S,3aR,7aS)-1H-Octahydroindole-2-carboxylic acid hydrochloride Perindopril Citric acid Perindopril erbumine Perindopril-N-desethylpentanoate 1H-Indole-2-carboxylicacid,2,3,4,5,6,7-hexahydro-,(2S)-(9CI) (R)-N-(1-Carboxyethyl)-D-norvaline 1-Ethyl Ester Perindopril EP Impurity L

OCTAHYDRO-INDOLE-2-CARBOXYLIC ACID

(2S,3αS,7αS)-Octahydro-1H-indole-2-carboxylic acid

[2S-(2a,3ab,7ab)]-Octahydro-1H-indole-2-carboxylic Acid

L-(2S,3aS,7aS)-Octahydroindole-2-carboxylic Acid

(2s,3as,7as)-Octahydro-1h-Indo

1H-Indole-2-carboxylicacid,octahydro-,(2S,3aS,7aS)-(9CI)

(2S,3aS,7aS)-2-Carboxyperhydroindole

(2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid

L-2-carboxyoctahydroindole

(2S,3aS,7aS)-1-Octahydro-1H-indole-2-car

(2S,3aS,7aS)-Octahydro-2-indolecarboxylicacid

(2s，3as，7as)-octabyche-lh-indole-2-carboxylicacid

L-Octahydroindole-2-carboxylic acid≥ 98% (HPLC)

L-Oic-OH

2S,3AS,7AS)-OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID(RE-EXP/IMPTD VDE BE N.9512629/9.6.15 P.NO.V/30/02/15/MISC/1 D.29.11.15

Perindopril Impurity 1(Perindopril EP Impurity A )

(2S,3As,7As)Octahydro-1H Indole-2-Carboxylic Acid (Ohi Acid)

(2S,3AS,7AS)-2-Carboxyoctahydroindole octahydro-1H-indole-2-carboxylic acid

Perindopril related compounds 7

[2S-(2a,3a,7a)]-Octahydro-1H-indole-2-carboxylic Acid

L-Octahydroindole-2-carboxylic acid ,98%

(2S,3aS,7aS)-2,3,3aβ,4,5,6,7,7aβ-Octahydro-1H-indole-2α-carboxylic acid

[2S,3aβ,7aβ,(-)]-Octahydro-1H-indole-2α-carboxylic acid

(2S,3aR,7aR)-2,3,3aα,4,5,6,7,7aα-Octahydro-1H-indole-2α-carboxylic acid

(2S,3aS,7As)-Octanhydro-1H-Indole-2-Carboxylic Acid

L-Octahydroindole-2-

Perindopril Intermediate 3

(2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid (InterMediates for Perindopril)

[2S-(2α,3aβ,7aβ)]-Octahydro-1H-indole-2-carboxylic Acid

H-Oic-OH, (2S,3aS,7aS)-1-Octahydro-1H-indole-2-carboxylic acid

1H-Indole-2-carboxylicacid, octahydro-, (2S,3aS,7aS)-

(2S,3aS,7aS)-OCLahydroindole-2-Carboxylic Acid

(2α,3aβ,7aβ)-octahydro-1H-indole-2-carboxylic acid

Perindopril EP IMpurity-A (USP RC A)

Perindopril EP IMpurity A

Perindopril Related CoMpound A

(2S,3aS,7aS)-Octahydroindole-2-carboxylicacid,98%

perindopril impurity

(S)-Octahydroindole-2-carboxylic acid

Ramipril Bicyclic Acid

Perindopril Related Compound 7

(2R,3aR,7aR)-octahydro-1H-indole-2-carboxylic acid

Perindopril tert-Butylamine Impurity Ⅰ:L-(2S,3aS,7aS)-Octahydroindole-2-carboxylic Acid

(2S,3aS,7aS)-Octahydro-1H-indole-2-

Perindopril impurity A CRS

(2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylicAcid&gt

(2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid(PER-6)

L-octahydroindole dicarboxylic acid

Perindopril EP Impurity A/Perindopril USP RC- A

Perindopril EP Impurity A (Ramipril Bicyclic Acid)

Ramipril Bicyclic Acid (Perindopril EP Impurity A)

Perindopril Related Compound A ((2S,3aS,7aS)-octahydro-1H-indole-2-carboxylic acid) (1510890)

perindopril impurity Ⅰ 〔 (2S,3aS,7aS)-octahydro-1H-i ndole-2-carboxylic acid〕

L-Octahydroindole-2-carboxylic

(2S,3αS,7αS)-Octahydro-1H-indole-2-carboxylicacid

Perindopril USP Related Compound A

(2S,3aS,7aS)-Octahydroindole-2-carboxylicaci

L-Octahydroindole-2-carboxylic acid /(2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic Acid