N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide

Product Name: N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide
CAS No.: 1042672-97-8
Chemical Name: N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide
Synonyms: CS-647;CS-2482;IRAK-IN-6;IRAK inhibitor 6;N-[2-methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-;N-(2-Methoxy-4-Morpholinophenyl)-2-(pyridin-3-yl)thiazole-4-carboxaMide;N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide;4-ThiazolecarboxaMide, N-[2-Methoxy-4-(4-Morpholinyl)phenyl]-2-(3-pyridinyl)-;Interleukin-1 receptor associated kinase,inhibit,Inhibitor,IL-1R associated kinase,IRAK inhibitor 6,IRAK inhibitor6,IRAK,IRAK inhibitor-6
CBNumber: CB32604265
Molecular Formula: C20H20N4O3S
Formula Weight: 396.46
MOL File: 1042672-97-8.mol

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N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide Property

Density: 1.335
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥9.9 mg/mL in DMSO
form: solid
pka: 10.19±0.70(Predicted)
color: Light brown to brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A3504
Product name: IRAKinhibitor6
Packaging: 10mM(in 1mL DMSO)
Price: $266
Updated: 2021/12/16

ChemScene

Product number: CS-0602
Product name: IRAKinhibitor6
Purity: 99.75%
Packaging: 10mg
Price: $396
Updated: 2021/12/16

ChemScene

Product number: CS-0602
Product name: IRAKinhibitor6
Purity: 99.75%
Packaging: 5mg
Price: $290
Updated: 2021/12/16

ChemScene

Product number: CS-0602
Product name: IRAKinhibitor6
Purity: 99.75%
Packaging: 50mg
Price: $1030
Updated: 2021/12/16

Crysdot

Product number: CD31004734
Product name: IRAKinhibitor6
Purity: 98+%
Packaging: 10mg
Price: $349
Updated: 2021/12/16

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N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide Chemical Properties,Usage,Production

Biological Activity

irak inhibitor 6 is an interleukin-1 receptor associated kinase 4 (irak-4) inhibitor.the interleukin-1 receptor associated kinases (iraks) are a family of serine/threonine kinases related with regulating cellular signalling downstream of the il-18, il-1 and various toll-like receptors. irak-4 is reported to be essential for the activation of the intracellular signalling cascades including nfкb and mapk pathways, which are critical for the production of inflammatory cytokines.

in vitro

a quantitative structure–activity relationship (qsar) study of irak inhibitor 6 and its analogs were conducted by using the genetic algorithm and multiple linear regression (ga-mlr) method [1]. in vitro study showed that compared with its unsubstituted phenyl amide analog, the ortho-substitution with chloro, methoxy and difluoromethoxy analogs of irak inhibitor 6 improved potency against irak-4 significantly. these potency effects were additive, with the most active example in the set being irak inhibitor 6, in which the presence of nitrogen-linked substituents at the para position had a beneficial effect on the rate of turnover by human microsomes (20 μl/min/mg protein) [2].

IC 50

0.16 μm for irak-4

References

[1] pourbasheer e, riahi s, ganjali mr, norouzi p. quantitative structure-activity relationship (qsar) study of interleukin-1 receptor associated kinase 4 (irak-4) inhibitor activity by the genetic algorithm and multiple linear regression (ga-mlr) method. j enzyme inhib med chem. 2010 dec;25(6):844-53.
[2] buckley gm, gowers l, higueruelo ap, jenkins k, mack sr, morgan t, parry dm, pitt wr, rausch o, richard md, sabin v, fraser jl. irak-4 inhibitors. part 1: a series of amides. bioorg med chem lett. 2008 jun 1;18(11):3211-4.

N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide Suppliers

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View Lastest Price from N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide manufacturers

Career Henan Chemical Co

Product: N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide 1042672-97-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-26

1042672-97-8, N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamideRelated Search:

N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide N-Methoxyphthalimide 6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine IRAK-1/4 INHIBITOR I 4-[[[3-(3,4-Dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]amino]methyl]benzenesulfonamide 4-[6-[[(Furan-2-yl)methyl]amino]imidazo[1,2-b]pyridazin-3-yl]phenol

N-(2-Methoxy-4-Morpholinophenyl)-2-(pyridin-3-yl)thiazole-4-carboxaMide

4-ThiazolecarboxaMide, N-[2-Methoxy-4-(4-Morpholinyl)phenyl]-2-(3-pyridinyl)-

N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide

IRAK inhibitor 6

N-[2-methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-

CS-2482

CS-647

IRAK-IN-6

Interleukin-1 receptor associated kinase,inhibit,Inhibitor,IL-1R associated kinase,IRAK inhibitor 6,IRAK inhibitor6,IRAK,IRAK inhibitor-6

1042672-97-8