ChemicalBook > CAS DataBase List > BI-97C1

BI-97C1

Product Name
BI-97C1
CAS No.
1228108-65-3
Chemical Name
BI-97C1
Synonyms
BI-97C1;Sabutoclax;BI-97C1 USP/EP/BP;BI-97C1;SABUTOCLAX;Sabutoclax(BI-97Cl);Sabutoclax, 10 mM in DMSO;(1R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5,N5'-bis((2R)-2-phenylpropyl)-[2,2'-binaphthalene]-5,5'-dicarboxamide;(1R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5,N5'-bis[(2R)-2-phenylpropyl]-[2,2'-binaphthalene]-5,5'-dicarboxamide;[2,2'-Binaphthalene]-5,5'-dicarboxamide, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5,N5'-bis[(2R)-2-phenylpropyl]-, (1R)
CBNumber
CB32628375
Molecular Formula
C42H40N2O8
Formula Weight
700.78
MOL File
1228108-65-3.mol
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BI-97C1 Property

Melting point:
>130°C (dec.)
Boiling point:
905.9±65.0 °C(Predicted)
Density 
1.358±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
Solid
pka
7.35±0.50(Predicted)
color 
Light Brown to Brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
S080780
Product name
Sabutoclax
Packaging
5mg
Price
$375
Updated
2021/12/16
TRC
Product number
S080780
Product name
Sabutoclax
Packaging
25mg
Price
$1215
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0001265
Product name
SABUTOCLAX
Purity
95.00%
Packaging
5MG
Price
$496.99
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
48618
Product name
Sabutoclax
Packaging
1mg
Price
$625
Updated
2021/12/16
ApexBio Technology
Product number
A4199
Product name
Sabutoclax
Packaging
50mg
Price
$675
Updated
2021/12/16
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BI-97C1 Chemical Properties,Usage,Production

Uses

Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.

Uses

Sabutoclax is a novel putative MCL-1 inhibitor that induces mitochondrial fragmentation either upstream of or independent of apoptosis.

Biological Activity

sabutoclax is an inhibitor of pan-bcl-2 family with ic50 values of 0.32, 0.31, 0.20 and 0.62 μm for bcl-2, bcl-xl, mcl-1 and bfl-1, respectively [1].sabutoclax is a derivative of apogossypolone. it showed a high binding affinity to bcl-xl both in nmr binding assay and in itc assay, with a kd value of 0.11μm. sabutoclax also showed better cell membrane permeability than other apogossypolone derivatives. in pc3 cells, sabutoclax inhibited cell growth with ec50 value of 0.13 μm. in human bp3 cell line, sabutoclax induced cell apoptosis with ic50 value of 0.049 μm. in mice bearing m2182 cancer xenografts, administration of sabutoclax significantly reduced the tumor size. at dose of 5 mg/kg, sabutoclax induced near complete tumor growth suppression [1].

in vivo

Sabutoclax (1-5 mg/kg; i.p.; every two days in 18 D) reduces tumor growth in M2182-bearing athymic nude mice[1].

Animal Model:athymic nude mice with tumor xenografts from M2182 cells in s.c.
Dosage:1 mg/kg, 3 mg/kg, 5 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Showed ihibiting tumor growth to about 60% of the tumor volume.

IC 50

Bcl-xL: 0.31 μM (IC50); BCL2: 0.32 μM (IC50); Mcl-1: 0.2 μM (IC50); Bfl-1: 0.62 μM (IC50)

References

[1] wei j, stebbins j l, kitada s, et al. bi-97c1, an optically pure apogossypol derivative as pan-active inhibitor of antiapoptotic b-cell lymphoma/leukemia-2 (bcl-2) family proteins. journal of medicinal chemistry, 2010, 53(10): 4166-4176.

BI-97C1 Preparation Products And Raw materials

Raw materials

Preparation Products

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BI-97C1 Suppliers

China 84 India 1 United States 10 Global 95
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
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58
ApexBio Technology
Tel
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Email
sales@apexbt.com
Country
United States
ProdList
6251
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58
Selleck Chemicals LLC
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info@selleckchem.com
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United States
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824
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60
Cayman Chemical Company
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cayman@caymanchem.com
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United States
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6213
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81
United States Biological
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chemicals@usbio.net
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United States
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6214
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Creative Enzymes
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Email
info@creative-enzymes.com
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United States
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1228108-65-3, BI-97C1Related Search:

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  • BI-97C1
  • Sabutoclax
  • (1R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5,N5'-bis[(2R)-2-phenylpropyl]-[2,2'-binaphthalene]-5,5'-dicarboxamide
  • [2,2'-Binaphthalene]-5,5'-dicarboxamide, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5,N5'-bis[(2R)-2-phenylpropyl]-, (1R)
  • BI-97C1;SABUTOCLAX
  • BI-97C1 USP/EP/BP
  • Sabutoclax(BI-97Cl)
  • (1R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5,N5'-bis((2R)-2-phenylpropyl)-[2,2'-binaphthalene]-5,5'-dicarboxamide
  • Sabutoclax, 10 mM in DMSO
  • 1228108-65-3
  • C42H40N2O8
  • Inhibitors