ChemicalBook > CAS DataBase List > SB1317

SB1317

Product Name: SB1317
CAS No.: 937270-47-8
Chemical Name: SB1317
Synonyms: CS-915;TG02;TG-02;(E/Z)-TG02;(E/Z)-SB1317;SB1317, >=98%;TG-02/SB-1317;(E/Z)-Zotiraciclib;Zotiraciclib free base;Zotiraciclib (SB1317) HCl;SB1317(TG-02) hydrochloride
CBNumber: CB32628476
Molecular Formula: C23H24N4O
Formula Weight: 372.46
MOL File: 937270-47-8.mol

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SB1317 Property

Boiling point:: 575.5±60.0 °C(Predicted)
Density: 1.16±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥44.87 mg/mL in DMSO; ≥3.98 mg/mL in EtOH with gentle warming and ultrasonic
form: solid
pka: 8.03±0.20(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T337705
Product name: TG02
Packaging: 5mg
Price: $140
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BS167349
Product name: SB 1317
Packaging: 25mg
Price: $150
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BS167349
Product name: SB 1317
Packaging: 10mg
Price: $125
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BS167349
Product name: SB 1317
Packaging: 100mg
Price: $375
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BS167349
Product name: SB 1317
Packaging: 50mg
Price: $437.5
Updated: 2021/12/16

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SB1317 Chemical Properties,Usage,Production

Uses

TG 02 is a cyclin dependent kinase inhibitors (CDK inhibitors) for the treatment of chronic lymphocytic leukemia.

in vivo

(E/Z)-Zotiraciclib (50 and 75 mg/kg; p.o. once daily for 3 weeks) inhibits tumor growth^[1].? (E/Z)-Zotiraciclib (15 and 75 mg/kg; p.o. once daily 2 days on and 5 days off; i.p. once daily 5 days on 5 days off) inhibits tumor growth in two manners^[1].

Animal Model:	Male BALB/c mice with HCT-116 colon cancer cells xenografts^[1]
Dosage:	50 and 75 mg/kg
Administration:	Oral gavage; 50 and 75 mg/kg once daily for 3 weeks
Result:	Significantly inhibited the growth of tumors with a mean TGI of 82%.

Animal Model:	Male BALB/c mice with lymphoma Ramos cells xenografts^[1]
Dosage:	15 and 75 mg/kg
Administration:	Oral gavage and intraperitoneal injection ; 75 mg/kg once daily 2 days on and 5 days off (p.o.) and 15 mg/kg once daily 5 days on 5 days off (i.p.)
Result:	Significantly inhibited the growth of tumors with mean TGIs of 42% and 63% for the oral and ip delivery methods, respectively.

IC 50

CDK2: 13 nM (IC₅₀); JAK2: 73 nM (IC₅₀); FLT3: 56 nM (IC₅₀)

SB1317 Preparation Products And Raw materials

Raw materials

Preparation Products

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SB1317 Suppliers

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937270-47-8, SB1317Related Search:

SB-649868 SB 204741 SB1317 SB216763 Sb-742457 MMP-2/MMP-9 INHIBITOR IV SB 242084 (hydrochloride) SB 415286 SB 202190 SB 431542 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime SB 269970 HYDROCHLORIDE 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline 4'-CHLORO-3-METHOXYCINNAMANILIDE SB-705498 SB 203580 SB242235 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride

TG-02/SB-1317

14-Methyl-20-oxa-5,7,14,27-tetraazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene

SB1317, >=98%

SB1317(TG-02) hydrochloride

CS-915

TG02; SB 1317; TG 02; SB-1317; TG-02

TG02;TG-02

20-Oxa-5,7,14,27-tetraazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene, 14-methyl-

(E/Z)-SB1317

(E/Z)-TG02

(E/Z)-Zotiraciclib

Zotiraciclib free base

Zotiraciclib (SB1317) HCl

multiple myeloma,JAK2,Fms like tyrosine kinase 3,Cyclin dependent kinase,JAK,FLT3,Janus kinase,CD135,leukemias,Inhibitor,CDK,CDK2,Cluster of differentiation antigen 135,inhibit,cancer,(E/Z)-Zotiraciclib,(E/Z) Zotiraciclib,(E/Z)Zotiraciclib

6-Methyl-12-oxa-3,6-diaza-2(4,2)-pyrimidina-1,4(1,3)-dibenzenacyclododecaphan-8-ene

(E/Z)-Zotiraciclib, 10 mM in DMSO

(E/Z)-Zotiraciclib ((E/Z)-TG-02, (E/Z)-SB1317)

(e)-6-methyl-12-oxa-3,6-diaza-2(4,2)-pyrimidina-1,4(1,3)-dibenzenacyclododecaphan-8-ene

937270-47-8