AZ20
- Product Name
- AZ20
- CAS No.
- 1233339-22-4
- Chemical Name
- AZ20
- Synonyms
- AZ20;CS-1335;AZ-20; AZ 20;;AZ20 USP/EP/BP;(3R)-4-[2-(3H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine;(R)-4-(2-(1H-Indol-4-yl)-6-(1-(methylsulfonyl)cyclopropyl)pyrimidin-4-yl)-3-methylmorpholine;4-[4-(1-Methanesulfonylcyclopropyl)-6-[(3R)-3-methylmorpholin-4-yl]pyrimidin-2-yl]-1H-indole;4-[4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-1H-indole;1H-Indole, 4-[4-[(3R)-3-methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-;4-[4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-1H-indole AZ20
- CBNumber
- CB32655393
- Molecular Formula
- C21H24N4O3S
- Formula Weight
- 412.51
- MOL File
- 1233339-22-4.mol
AZ20 Property
- Boiling point:
- 634.6±55.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- -20°
- solubility
- Soluble in DMSO (up to 20 mg/ml).
- form
- solid
- pka
- 15.65±0.30(Predicted)
- color
- Off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 17589
- Product name
- AZ 20
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $26
- Updated
- 2024/03/01
- Product number
- 17589
- Product name
- AZ 20
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $58
- Updated
- 2024/03/01
- Product number
- 17589
- Product name
- AZ 20
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $102
- Updated
- 2024/03/01
- Product number
- 17589
- Product name
- AZ 20
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $625
- Updated
- 2023/06/20
- Product number
- 5198
- Product name
- AZ20
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $1217
- Updated
- 2021/12/16
AZ20 Chemical Properties,Usage,Production
Description
AZ20 (1233339-22-4) is a potent and highly selective inhibitor of Ataxia telangiectasia mutated and RAD3-related (ATR) kinase (IC50?= 5 nM in vitro; IC50?= 50 nM in HT29 colorectal adenocarcinoma cells).1?Combination therapy with AZ20 and gemcitabine resulted in synergistic inhibition of tumor cell growth and cell death initiation in pancreatic cancer cell lines.2
Uses
AZ20 is a potent and selective inhibitor of ATR (ATM-Rad3-related) kinase with in vivo antitumor activity.
Definition
ChEBI: (3R)-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)-4-pyrimidinyl]-3-methylmorpholine is a member of indoles.
storage
Store at -20°C
References
1) Foote?et al.?(2013)?Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy In Vivo Antitumor Activity; J. Med. Chem.?56?2125 2) Liu?et al.?(2017)?Inhibition of ATR potentiates the cytotoxic effect of gemcitabine on pancreatic cancer cell lines through enhancement of DNA damage and abrogation of ribonucleotide reductase induction by gemcitabine; Oncol. Rep.?37?3377
AZ20 Preparation Products And Raw materials
Raw materials
Preparation Products
AZ20 Suppliers
View Lastest Price from AZ20 manufacturers
- Product
- AZ20 1233339-22-4
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23