ChemicalBook > CAS DataBase List > XL019

XL019

Product Name
XL019
CAS No.
945755-56-6
Chemical Name
XL019
Synonyms
XL019;XL019, >95%;XL019/XL-019;XL019, >=98%;XL019 USP/EP/BP;XL019, 10 mM in DMSO;XL019; XL-019; XL 019.;XL019 XL-019 JAK2 Inhibitor;(S)-N-(4-(2-(4-MORPHOLINOPHENYLAMINO)PYRIMIDIN-4-YL)PHENYL)PYRROLIDINE-2-CARBOXAMIDE;(2S)-N-[4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide
CBNumber
CB32664379
Molecular Formula
C25H28N6O2
Formula Weight
444.53
MOL File
945755-56-6.mol
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XL019 Property

storage temp. 
Store at -20°C
solubility 
insoluble in EtOH; insoluble in H2O; ≥11.125 mg/mL in DMSO
form 
solid
color 
Green to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2393
Product name
XL019
Purity
≥98% (HPLC)
Packaging
5mg
Price
$71.54
Updated
2025/07/31
Sigma-Aldrich
Product number
SML2393
Product name
XL019
Purity
≥98% (HPLC)
Packaging
25mg
Price
$213.5
Updated
2025/07/31
Cayman Chemical
Product number
16298
Product name
XL019
Purity
≥90%
Packaging
1mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
16298
Product name
XL019
Purity
≥90%
Packaging
5mg
Price
$343
Updated
2024/03/01
Cayman Chemical
Product number
16298
Product name
XL019
Purity
≥90%
Packaging
10mg
Price
$593
Updated
2024/03/01
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XL019 Chemical Properties,Usage,Production

Uses

XL019 is used in the synthesis of JAK-2 modulators for the treatment of related diseases.

Biological Activity

XL019 is an ATP-binding site-targeting, orally active JAK2 subtype-selective Janus kinase inhibitor (IC50 in nM = 2.2/JAK2 vs. 134.3/JAK1, 214.2/JAK3, 348.3/TYK2) with much reduced or little activity against 116 other kinases (IC50 in nM = 125.4/PDGFRB, 139.7/FLT3, 225.8/c-KIT, 313.8/p70S6K, 370/MLK1, 375.4/IKKbeta, 483.6/KDR, 546.7/PDGFRA, 554.5/FLT4, 910.5/FLT; IC50 >1 μM toward remaining 106 kinases), CYP (1A2, 2C9, 2D6, 3A4 IC50 ≥20 μM), hERG (IC50 = 16 μM), and P-glycoprotein (IC50 >20 μM). XL019 effectively inhibits cellular STAT1/STAT3 phosphorylation both in HEL92.1.7 cultures (IC50 in nM = 386.4/pStat1 and 695/pStat3) and in HEL92.1.7 xenograft-derived tumor in mice in vivo (oral ED50 in mg/kg = 42/pStat1 and 210/pStat3) with significant HEL92.1.7 tumor suppression efficacy in mice (by 60% and 70% on day 14, respectively, with 200 and 300 mg/kg bid p.o. dosage).

target

JAK2

XL019 Preparation Products And Raw materials

Raw materials

Preparation Products

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XL019 Suppliers

Canada 1 China 114 India 2 United States 14 Global 131
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View Lastest Price from XL019 manufacturers

Career Henan Chemical Co
Product
XL019 945755-56-6
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

945755-56-6, XL019Related Search:

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  • 2S)-N-[4-[2-[[4-(4-Morpholinyl)phenyl]amino]-4-pyrimidinyl]phenyl]-2-pyrrolidinecarboxamide XL019
  • XL019 2-Pyrrolidinecarboxamide, N-[4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]phenyl]-, (2S)-
  • Pyrrolidine-2-carboxylic acid {4-[2-(4-morpholin-4-yl-phenylamino)-pyrimidin-4-yl]-phenyl}-amide
  • XL019, >=98%
  • XL019, >95%
  • XL019; XL-019; XL 019.
  • XL019
  • XL019/XL-019
  • (2S)-N-[4-[2-[[4-(4-Morpholinyl)phenyl]amino]-4-pyrimidinyl]phenyl]-2-pyrrolidinecarboxamide
  • (S)-N-(4-(2-(4-MORPHOLINOPHENYLAMINO)PYRIMIDIN-4-YL)PHENYL)PYRROLIDINE-2-CARBOXAMIDE
  • 2-Pyrrolidinecarboxamide, N-[4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]phenyl]-, (2S)-
  • (2S)-N-[4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide
  • XL019 USP/EP/BP
  • XL019 XL-019 JAK2 Inhibitor
  • XL019, 10 mM in DMSO
  • 945755-56-6
  • JAK
  • Inhibitors
  • STAT