SR2516

Product Name: SR2516
CAS No.: 1061353-68-1
Chemical Name: SR2516
Synonyms: SR2516;VS4817;VS-4718;SR-2516;SR-2156;PND1186;SR 2516;CS-1780;VC-4718;PND-1186
CBNumber: CB32666676
Molecular Formula: C25H26F3N5O3
Formula Weight: 501.5
MOL File: 1061353-68-1.mol

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SR2516 Property

Boiling point:: 654.0±55.0 °C(Predicted)
Density: 1.334±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥50.2 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form: solid
pka: 14.58±0.46(Predicted)
color: White to gray

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17668
Product name: PND1186
Purity: ≥98%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 17668
Product name: PND1186
Purity: ≥98%
Packaging: 50mg
Price: $275
Updated: 2024/03/01

Cayman Chemical

Product number: 17668
Product name: PND1186
Purity: ≥98%
Packaging: 1mg
Price: $35
Updated: 2021/12/16

Cayman Chemical

Product number: 17668
Product name: PND1186
Purity: ≥98%
Packaging: 10mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 17668
Product name: PND1186
Purity: ≥98%
Packaging: 25mg
Price: $179
Updated: 2024/03/01

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SR2516 Chemical Properties,Usage,Production

Uses

PND-1186 is a FAK inihbitor which selectively promotes tumor cell apoptosis in 3D environments.

Synthesis

209960-91-8

1061358-71-1

1061353-68-1

General procedure for the synthesis of 2-((2-((2-methoxy-4-morpholinophenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide from 2-methoxy-4-morpholinophenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide: In a microwave tube, 2-{[2-chloro-5- (trifluoromethyl)-4-pyridinyl]amino}-N-methylbenzamide (Intermediate 1, 50 mg, 0.152 mmol) was mixed with 2-methoxy-4-morpholinoaniline (148 mg, 0.607 mmol), 1M hydrochloric acid (0.303 mL, 0.303 mmol), 1,4-dioxane (0.2 mL) and water (2.5 mL). The mixture was placed in a microwave reactor and irradiated at 170°C for 25 minutes. After completion of the reaction, the crude product was collected by filtration and the filtrate was purified by reversed-phase high performance liquid chromatography (HPLC) to afford the target compound 2-((2-((2-methoxy-4-morpholinophenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide (35.5 mg, 0.071 mmol, 46.7% yield). Mass spectrum (MS): molecular weight of molecular formula C25H26F3N5O3 (M) = 471.48, (M+H)+ =472; 1H NMR (400 MHz, methanol-d4) δppm 2.88 (s, 3H), 3.05-3.14 (m, 4H), 3.78-3.91 (m, 7H), 6.45 (s, 1H), 6.52 ( dd, J=8.59,2.53Hz, 1H), 6.64 (d, J=2.53Hz, 1H), 7.03-7.13 (m, 1H), 7.30 (d, J=8.59Hz, 1H), 7.40-7.50 (m, 2H), 7.61 (dd, J=7.83,1.26Hz, 1H), 8.10 (s, 1H).

in vivo

PND-1186 (30 mg/kg or 100 mg/kg; subcutaneously; injected subcutaneously in the neck region) inhibits 4T1 subcutaneous tumor growth by induction of apoptosis^[1].

Animal Model:	BALB/c mice^[1]
Dosage:	30 mg/kg or 100 mg/kg
Administration:	Injected (100 μL) subcutaneously in the neck region; every 12 h (twice-daily, b.i.d.) for 5 days.
Result:	100 mg/kg treatment significantly reduced final 4T1 tumor weight 2-fold whereas 30 mg/kg treatment slightly reduced final tumor weight but was not significantly different compared to control.

target

FAK

storage

Store at -20°C

References

[1] Patent: WO2009/105498, 2009, A1. Location in patent: Page/Page column 27-28

SR2516 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR2516 Suppliers

China 137 India 1 United States 13 Global 151

BOC Sciences

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Target molecule Corp.

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Musechem

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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
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InvivoChem

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Fax: 708-557-7486
Email: sales@invivochem.cn
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Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
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Cayman Chemical Company

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1061353-68-1, SR2516Related Search:

Defactinib Selumetinib Saracatinib Vorinostat BIRB 796 (Doramapimod) Entinostat

PND 1186

PND1186

PND-1186

SR 2516

SR2516

SR-2516

VS-4718

PND-1186 (VS-4718)

2-(2-(2-methoxy-4-morpholinophenylamino)-5-(trifluoromethyl)pyridin-4-ylamino)-N-methylbenzamide

SR-2156

SR 2516 PND-1186 (VS-4718)

VS-4718(PND1186)

2-[[2-[[2-Methoxy-4-(4-morpholinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyridinyl]amino]-N-methylbenzamide

PND-1186, >=98%

VS-4718, CT-VS4718, PND-1186, SR 2516

PND-1186,SR-2156

PND-1186;VS-4718;PND 1186;PND1186

PND1186 10MG

2-{[2-{[2-methoxy-4-(4-morpholinyl)phenyl]amino}-5-(trifluorometh Yl)-4-pyridinyl]amino}-n-methylbenzamide Hydrochloride (1:1)

PND-1186 (SR-2516

SR-2516; PND 1186; PND1186; SR 2516; SR2516

CS-1780

PND 1186 - SR 2516 | VS 4718

SR-2516;PND 1186;PND1186;SR 2516;SR2516;VS-4718;VS 4718;VS4718

VS4817

Benzamide, 2-[[2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyridinyl]amino]-N-methyl-

SR2516 USP/EP/BP

VC-4718

1061353-68-1

C25H26F3N5O3

API

Inhibitors