XL-388

Product Name: XL-388
CAS No.: 1251156-08-7
Chemical Name: XL-388
Synonyms: XL388;XL-388;CS-772;XL 388;XL388, >=98%;XL-388;XL 388;XL-388 USP/EP/BP;XL388, 10 mM in DMSO;Carbamazepine 298-46-4 three units, HPLC Purity : XL388;inhibit,XL388,XL 388,Mammalian target of Rapamycin,Inhibitor,mTOR,XL-388
CBNumber: CB32666702
Molecular Formula: C23H22FN3O4S
Formula Weight: 455.5
MOL File: 1251156-08-7.mol

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XL-388 Property

Melting point:: >188oC (dec.)
Boiling point:: 738.6±60.0 °C(Predicted)
Density: 1.354±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 6.22±0.13(Predicted)
form: Solid
color: Off-White to Pale Yellow
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1239
Product name: XL388
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $58.4
Updated: 2024/03/01

Cayman Chemical

Product number: 20237
Product name: XL388
Purity: ≥98%
Packaging: 5mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 20237
Product name: XL388
Purity: ≥98%
Packaging: 10mg
Price: $230
Updated: 2024/03/01

Cayman Chemical

Product number: 20237
Product name: XL388
Purity: ≥98%
Packaging: 25mg
Price: $505
Updated: 2024/03/01

Cayman Chemical

Product number: 20237
Product name: XL388
Purity: ≥98%
Packaging: 50mg
Price: $903
Updated: 2024/03/01

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XL-388 Chemical Properties,Usage,Production

Uses

XL388 is a highly potent, orally bioavailable, selective, ATP-competitive mammalian target of rapamycin (mTOR) inhibitor. XL388 has shown significant and dose-dependent antitumor activity in athymic nude mice implanted with human tumor xenografts.

Biological Activity

XL388 is a potent, selective, orally bioavailable ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) with an IC50 of 9.9 nM for mTOR, 8 nM for mTORC1, 166 nM for mTORC2, and 1000-fold selectivity for mTOR over the closely related PI3K kinases and a panel of 141 protein kinases tested. XL388 blocked mTORC1 phosphorylation of p70S6K (T389) with an IC50 value of 94 nM and blocked mTORC2 phosphorylationof AKT (S473) with an IC50 value of 350 nM. XL388 showed complete tumor growth inhibition in mice bearing MCF-7 xenograft tumors.

XL-388 Preparation Products And Raw materials

Raw materials

Preparation Products

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XL-388 Suppliers

China 80 India 2 United Kingdom 2 United States 17 Global 101

MedChemexpress LLC

Tel: 021-58955995
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Target molecule Corp.

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Musechem

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TargetMol Chemicals Inc.

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Cckinase, Inc.

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Aladdin Scientific

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TargetMol Chemicals Inc.

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ApexBio Technology

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Cayman Chemical Company

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United States Biological

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Creative Enzymes

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MedChemExpress

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Matrix Scientific

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Santa Cruz Biotechnology, Inc.

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NE Scientific

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1251156-08-7, XL-388Related Search:

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Methanone, [7-(6-amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-

[7-(6-Amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-methanone XL388

XL388, >=98%

(7-(6-Aminopyridin-3-yl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)(3-fluoro-2-methyl-4-(methy

XL 388

XL388

XL-388

[7-(6-Amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-methanone

Carbamazepine 298-46-4 three units, HPLC Purity : XL388

XL-388;XL 388

CS-772

XL-388 USP/EP/BP

(7-(6-Aminopyridin-3-yl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)(3-fluoro-2-methyl-4-(methylsulfonyl)phenyl)methanone

inhibit,XL388,XL 388,Mammalian target of Rapamycin,Inhibitor,mTOR,XL-388

XL388, 10 mM in DMSO

1251156-08-7

PI3K/Akt/mTOR

Akt

mTOR

PI3K

Inhibitors