Canagliflozin heMihydrate
- Product Name
- Canagliflozin heMihydrate
- CAS No.
- 928672-86-0
- Chemical Name
- Canagliflozin heMihydrate
- Synonyms
- Canagliflozin hydrate;Cagliflozin heMihydrate;(2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol Hemihydrate;Cageline;NSC 36678;NSC 406879;Kagliflozin;TA7284 hemihydrate;TA-7284 hemihydrate;Invokana hemihydrate
- CBNumber
- CB32677171
- Molecular Formula
- 2(C24H25FO5S).H2O
- Formula Weight
- 462.53
- MOL File
- 928672-86-0.mol
Canagliflozin heMihydrate Property
- Melting point:
- 94-96°C
- storage temp.
- Hygroscopic, Refrigerator, under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
- InChIKey
- RCCZPUWDQVUJAB-HNJBBDRUNA-N
- SMILES
- O[C@@H]1[C@H]([C@H](O)[C@@H](CO)O[C@H]1C1C=CC(C)=C(CC2=CC=C(C3C=CC(F)=CC=3)S2)C=1)O.O |&1:1,2,3,5,9,r|
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C175258
- Product name
- CanagliflozinHemihydrate
- Packaging
- 10mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- C175258
- Product name
- CanagliflozinHemihydrate
- Packaging
- 50mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- FC103621
- Product name
- Canagliflozin hemihydrate
- Packaging
- 10mg
- Price
- $44
- Updated
- 2021/12/16
- Product number
- CS-3205
- Product name
- Canagliflozinhemihydrate
- Purity
- 99.95%
- Packaging
- 5mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-3205
- Product name
- Canagliflozinhemihydrate
- Purity
- 99.95%
- Packaging
- 10mg
- Price
- $70
- Updated
- 2021/12/16
Canagliflozin heMihydrate Chemical Properties,Usage,Production
Description
Canagliflozin, an orally active and selective sodium–glucose cotransporter 2 (SGLT2) inhibitor, was co-developed by Mitsubishi Tanabe Pharma and Johnson & Johnson (J&J) for the treatment of type 2 diabetes mellitus (T2DM) and obesity. The drug was approved in March by the U.S. FDA and launched in April 2013 in the U.S. SGLT2 is involved in the glucose re-absorption pathway in the kidney, and its inhibition increases urinary glucose excretion, and reduces plasma glucose and HbA1c levels. In addition, canagliflozin is safe in combination with other commonly used antidiabetic agents and has a significant effect on body weight reduction. A recently published process patent from ScinoPharm Taiwan describes the synthesis of canagliflozin.
Uses
Canagliflozin Hemihydrate is a derivative of Canagliflozin (C175190), which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity.
Definition
ChEBI: Canagliflozin hydrate is a hydrate that is the hemihydrate form of canagliflozin. Used for treatment of type II diabetes via inhibition of sodium-glucose transport protein subtype 2. It has a role as a hypoglycemic agent and a sodium-glucose transport protein subtype 2 inhibitor. It contains a canagliflozin.
Synthesis
Synthesis of the aglycone region of canagliflozin was described in a separate patent by first condensing commercially available 5- bromo-2-methylbenzoyl chloride (14) and 2-(4-fluorophenyl)- thiophene (15) under Friedel¨CCrafts acylation conditions to give ketone 16 in 69% yield as a crystalline solid. Ketone 16 was then reduced with triethylsilyl hydride in the presence of BF3Et2O at low temperature to give aglycone bromide 17 in 70% yield. The precursor for the glycoside moiety, commercially available glycoside triol 18, was selectively treated with t-butyldiphenylsilyl chloride (TBDPSCl) in THF in the presence of imidazole to give the bis-silyl ether 19 in 81% yield. Next, a unique, stereospecific b-C-arylglucosidation was developed to secure the union of the aglyone- and glycoside-containing portions of canagliflozin. Bromide 17 was subjected to magnesium powder under standard Grignard conditions prior to treatment with AlCl3 in THF in situ. This resulting mixture was then exposed to a solution of compound 19 in PhOMe which had been pre-treated with n-BuLi, and the entire mixture was then warmed to 150 ?? for 5 h to ultimately give the b-anomer 20 in 56% yield. Finally, removal of the silyl groups within 20 with tetrabutyl ammonium fluoride (TBAF) in THF delivered canagliflozin hydrate (III) in 73% yield.
Canagliflozin heMihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Canagliflozin heMihydrate Suppliers
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
- info@novachemistry.com
- Country
- United Kingdom
- ProdList
- 4381
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
View Lastest Price from Canagliflozin heMihydrate manufacturers
- Product
- Canagliflozin hemihydrate 928672-86-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%，single impurity＜0.1
- Supply Ability
- 1 ton
- Release date
- 2024-01-04
- Product
- Canagliflozin Hemihydrate 928672-86-0
- Price
- US $0.00/G
- Min. Order
- 1G
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-09-04
- Product
- Canagliflozin heMihydrate 928672-86-0
- Price
- US $10.00/KG
- Min. Order
- 100KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2021-10-09