ChemicalBook > CAS DataBase List > Isoangustone A

Isoangustone A

Product Name: Isoangustone A
CAS No.: 129280-34-8
Chemical Name: Isoangustone A
Synonyms: Isoangustone A;3-[3,4-Dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)-4H-chromen-4-one;3-[3,4-Dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 3-[3,4-dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)-
CBNumber: CB32681288
Molecular Formula: C25H26O6
Formula Weight: 422.47
MOL File: 129280-34-8.mol

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Isoangustone A Property

form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: I778810
Product name: IsoangustoneA
Packaging: 10mg
Price: $1760
Updated: 2021/12/16

Arctom

Product number: AS307824
Product name: IsoangustoneA
Purity: ≥98%
Packaging: 5mg
Price: $371
Updated: 2021/12/16

Crysdot

Product number: CD32002600
Product name: IsoangustoneA
Purity: 95+%
Packaging: 5mg
Price: $802
Updated: 2021/12/16

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Isoangustone A Chemical Properties,Usage,Production

Uses

Isoangustone A is a secondary metabolite of Licorice. Isoangustone A was shown to suppress the proliferation of human melanoma cells and induce apoptosis in colorectal cancer cells.

Definition

ChEBI: Isoangustone A is a member of isoflavanones.

in vivo

Isoangustone A (2 or 10 mg/kg; i.p.; daily for 35 days) significantly decreases tumor growth, volume, and weight of SK-MEL-28 xenografts in mice^[1].

Animal Model:	Male Balb/c nu/nu mice, SK-MEL-28 xenograft model^[1]
Dosage:	2 or 10 mg/kg
Administration:	Intraperitoneal injection, daily for 35 days
Result:	Significantly suppressed tumor weight compared to the control group. Markedly inhibited the expression of proliferating cell nuclear antigen (PCNA). Decreased phosphorylation levels of Akt.

Isoangustone A Preparation Products And Raw materials

Raw materials

Preparation Products

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129280-34-8, Isoangustone ARelated Search:

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Isoangustone A

3-[3,4-Dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one

3-[3,4-Dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)-4H-chromen-4-one

4H-1-Benzopyran-4-one, 3-[3,4-dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)-

129280-34-8