ChemicalBook > CAS DataBase List > SiraMesine, Lu-28-179

SiraMesine, Lu-28-179

Product Name
SiraMesine, Lu-28-179
CAS No.
224177-60-0
Chemical Name
SiraMesine, Lu-28-179
Synonyms
Siramesine.HCl;Xanthine Impurity 7;SiraMesine, Lu-28-179;Lu 28-179 hydrochlorid;LU 28-179 HYDROCHLORIDE;Siramesine, Lu-28-179 HCl;SiraMesine (hydrochloride);Siramesine hydrochloride, >=98%;Siramesine (HCl salt), Lu-28-179;SiramesineLu-28-179 hydrochloride
CBNumber
CB32685327
Molecular Formula
C30H32ClFN2O
Formula Weight
491.0392832
MOL File
224177-60-0.mol
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SiraMesine, Lu-28-179 Property

Melting point:
225 °C
storage temp. 
Sealed in dry,Room Temperature
solubility 
>49.1mg/mL in DMSO
form 
powder to crystal
color 
White to Light yellow
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Safety

HS Code 
2934.99.4700
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
I1090
Product name
Siramesine Hydrochloride
Packaging
5MG
Price
$55
Updated
2025/07/31
TCI Chemical
Product number
I1090
Product name
Siramesine Hydrochloride
Packaging
25MG
Price
$177
Updated
2025/07/31
Tocris
Product number
6740
Product name
Siramesine Hydrochloride
Purity
≥98%(HPLC)
Packaging
5
Price
$100
Updated
2021/12/16
Tocris
Product number
6740
Product name
Siramesine Hydrochloride
Purity
≥98%(HPLC)
Packaging
25
Price
$389
Updated
2021/12/16
Biorbyt Ltd
Product number
orb181321
Product name
Siramesine Hydrochloride
Purity
>98%
Packaging
100mg
Price
$950.3
Updated
2021/12/16
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SiraMesine, Lu-28-179 Chemical Properties,Usage,Production

Uses

Siramesine (Lu 28-179) hydrochloride is a potent sigma-2 receptor agonist. Siramesine hydrochloride has a subnanomolar affinity for sigma-2 receptors (IC50=0.12?nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17?nM). Siramesine hydrochloride triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity[1][2][3].

IC 50

Sigma 1 Receptor

storage

Store at -20°C

SiraMesine, Lu-28-179 Preparation Products And Raw materials

Raw materials

Preparation Products

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SiraMesine, Lu-28-179 Suppliers

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View Lastest Price from SiraMesine, Lu-28-179 manufacturers

Career Henan Chemical Co
Product
SiraMesine, Lu-28-179 224177-60-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-02

224177-60-0, SiraMesine, Lu-28-179Related Search:

Epi-Lacosamide-d3 (1.0 mg/mL in Acetonitrile) Dibutyl phosphate 6-HYDROXYWARFARIN CBPNZQVSJQDFBE-VUWIKSLBSA-N CX-4945 SIRAMESINE ACRYLAMIDE-2,3,3-D3 diisopentyl phthalate (2-Fosfomycinyl-1-(hydroxy)propyl)phosphonic Acid Diflunisal Impurity 1 Tolclofos-methyl 17-Methoxycarbonyl Loteprednol Isopentyl Pentyl Phthalate Tributyl phosphate LUMIRACOXIB Lacosamide Impurity 11 Lacosamide Impurity 25 4-AMINOAZOBENZENE

  • SiraMesine, Lu-28-179
  • SiraMesine (hydrochloride)
  • 1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]butyl]spiro[isobenzofuran-1(3H),4'-piperidine] monohydrochloride
  • Siramesine hydrochloride, >=98%
  • Siramesine (HCl salt), Lu-28-179
  • Siramesine hydrochloride 1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]butyl]spiro[isobenzofuran-1(3H),4'-piperidine] monohydrochloride
  • SiraMesine, Lu-28-179 1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]butyl]spiro[isobenzofuran-1(3H),4'-piperidine] monohydrochloride
  • SiramesineLu-28-179 hydrochloride
  • Siramesine.HCl
  • Siramesine, Lu-28-179 HCl
  • LU 28-179 HYDROCHLORIDE
  • Lu 28-179 hydrochlorid
  • 1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]butyl]-3H-spiro[isobenzofuran-1,4'-piperidine] Hydrochloride
  • Sigma Receptor,mitochondria,cathepsin,Ferroptosis,selectivity,lysosomes,Siramesine hydrochloride,Siramesine,Inhibitor,Lu 28-179,inhibit,cancer,death
  • 1'-(4-(1-(4-Fluorophenyl)-1H-indol-3-yl)butyl)-3H-spiro[isobenzofuran-1,4'-piperidine] hydrochloride
  • Xanthine Impurity 7
  • Siramesine hydrochloride, 10 mM in DMSO
  • 224177-60-0
  • C30H31FN2OHCl
  • Inhibitors