ChemicalBook > CAS DataBase List > 6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID

6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID

Product Name: 6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID
CAS No.: 98948-95-9
Chemical Name: 6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID
Synonyms: AURORA 19699;BUTTPARK 21\09-50;OTAVA-BB BB7110950773;6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID;6-bromo-4-hydroxy-3-quinolinecarboxylic acid;4-Hydroxy-6-broMoquinoline-3-carboxylic acid;3-Quinolinecarboxylic acid, 6-bromo-4-hydroxy-;6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID CAS:98948-95-9
CBNumber: CB3270974
Molecular Formula: C10H6BrNO3
Formula Weight: 268.06
MOL File: 98948-95-9.mol

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6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID Property

Melting point:: 271 °C (decomp)
Boiling point:: 436.9±45.0 °C(Predicted)
Density: 1.862±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
pka: 0.59±0.30(Predicted)
form: solid
Appearance: Off-white to gray Solid
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C10H6BrNO3/c11-5-1-2-8-6(3-5)9(13)7(4-12-8)10(14)15/h1-4H,(H,12,13)(H,14,15)
InChIKey: GIUZUAUCCUFVKW-UHFFFAOYSA-N
SMILES: N1C2C(=CC(Br)=CC=2)C(O)=C(C(O)=O)C=1
CAS DataBase Reference: 98948-95-9

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: OTV000323
Product name: 6-Bromo-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
Purity: Aldrich<SUP>CPR</SUP>
Packaging: 1 g
Price: $259
Updated: 2025/07/31

Sigma-Aldrich

Product number: BBO000200
Product name: 6-Bromo-4-hydroxyquinoline-3-carboxylic acid
Purity: Aldrich
Packaging: 1g
Price: $259
Updated: 2025/07/31

TRC

Product number: B696265
Product name: 6-Bromo-4-hydroxyquinoline-3-carboxylic acid
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB150804
Product name: 6-Bromo-4-hydroxyquinoline-3-carboxylic acid
Packaging: 100mg
Price: $67
Updated: 2021/12/16

ChemScene

Product number: CS-M0118
Product name: 6-Bromo-4-hydroxyquinoline-3-carboxylic acid
Packaging: 10g
Price: $111
Updated: 2021/12/16

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6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

It is used as a pharmaceutical intermediate.

Synthesis

122794-99-4

98948-95-9

The general procedure for the synthesis of 4-hydroxy-6-bromoquinoline-3-carboxylic acid from ethyl 6-bromo-4-hydroxy-3-quinolinecarboxylate was as follows: ethyl 6-bromo-4-hydroxy-3-quinolinecarboxylate (102.59 g, 337.7 mmol) was suspended in a 10% aqueous potassium hydroxide solution (689 mL) and heated and refluxed for 5 hours, and the reaction solution changed to light brown. After completion of the reaction, it was cooled to room temperature and filtered to remove undissolved solid particles. The filtrate was extracted with dichloromethane to remove neutral impurities. The aqueous layer was neutralized with 3.0 N hydrochloric acid to precipitate a white precipitate. The solid was collected by filtration and washed with water. After drying in air, 4-hydroxy-6-bromoquinoline-3-carboxylic acid was obtained as 91 g (98% yield) as a white solid.EI-HRMS m/e calculated value of C10H6BrNO3 (M+) 266.9531, measured value 266.9521.

References

[1] Patent: US2006/63805, 2006, A1. Location in patent: Page/Page column 9
[2] ChemMedChem, 2015, vol. 10, # 5, p. 836 - 849
[3] Patent: CN106432073, 2017, A. Location in patent: Paragraph 0061; 0062; 0067; 0068
[4] European Journal of Medicinal Chemistry, 2015, vol. 99, p. 36 - 50
[5] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1995, vol. 31, # 2, p. 167 - 175

6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co

Product: 6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID 98948-95-9
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-10

98948-95-9, 6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACIDRelated Search:

OTAVA-BB BB7110950773

6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID

AURORA 19699

BUTTPARK 21\09-50

4-Hydroxy-6-broMoquinoline-3-carboxylic acid

6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID CAS:98948-95-9

6-bromo-4-hydroxy-3-quinolinecarboxylic acid

3-Quinolinecarboxylic acid, 6-bromo-4-hydroxy-

98948-95-9

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