EveroliMus-d4
- Product Name
- EveroliMus-d4
- CAS No.
- 1338452-54-2
- Chemical Name
- EveroliMus-d4
- Synonyms
- Everolimus-d4;EveroliMus-d4 (~90%);Everolimus-d4 (Everolimus Impurity);EVEROLIMUS (2-HYDROXYETHYL-D4, 98%);Everolimus Impurity 24(Everolimus-d4);Everolimus D4Q: What is Everolimus D4 Q: What is the CAS Number of Everolimus D4 Q: What is the storage condition of Everolimus D4 Q: What are the applications of Everolimus D4
- CBNumber
- CB32714520
- Molecular Formula
- C53H79D4NO14
- Formula Weight
- 962.249067112
- MOL File
- 1338452-54-2.mol
EveroliMus-d4 Property
- storage temp.
- Store at 4°C
- solubility
- Chloroform: Soluble,Methanol: Soluble
- form
- A solid
- Stability:
- Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P314Get medical advice/attention if you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E-070
- Product name
- Everolimus-D4 solution
- Purity
- 100?μg/mLinacetonitrile,ampuleof1?mL,certifiedreferencematerial,Cerilli
- Packaging
- 1mL
- Price
- $586
- Updated
- 2024/03/01
- Product number
- 22559
- Product name
- Everolimus-d4
- Purity
- ≥99% deuterated forms (d1-d4); ≤1% d0
- Packaging
- 500μg
- Price
- $145
- Updated
- 2024/03/01
- Product number
- 22559
- Product name
- Everolimus-d4
- Purity
- ≥99% deuterated forms (d1-d4); ≤1% d0
- Packaging
- 1mg
- Price
- $262
- Updated
- 2024/03/01
- Product number
- E945402
- Product name
- Everolimus-d4(~90%)
- Packaging
- 10mg
- Price
- $1695
- Updated
- 2021/12/16
- Product number
- 14001
- Product name
- Everolimus-[d4]
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $190
- Updated
- 2021/12/16
EveroliMus-d4 Chemical Properties,Usage,Production
Description
Everolimus-d4 is intended for use as an internal standard for the quantification of everolimus by GC- or LC-MS. Everolimus is a hydroxyethyl ether form of rapamycin that inhibits mTOR signaling through both mTORC1 and mTORC2 when added to cells at 20 nM. It is orally available and shows improved pharmacokinetics and pharmacodynamics over rapamycin. Through its inhibition of mTOR, everolimus inhibits cell proliferation, metabolism, and angiogenesis in certain types of cancer. It also acts as an immunosuppressive agent in the context of organ transplantation.
Uses
Macrolide immunosuppressant; derivative of Rapamycin. Inhibits cytokine-mediated lymphocyte proliferation.
General Description
A stable-labeled internal standard for the immunosuppressant Everolimus, marketed as Zortress? and Certican for use in organ transplantation and Afinitor? for treatment of kidney and pancreatic cancers. Clinical laboratories quantitate everolimus levels in patient whole blood samples using LC-MS/MS. While many everolimus LC-MS/MS methods use 32-desmethoxyrapamycin or ascomycin as an internal standard, higher levels of variability / lower levels of reproducibility may occur in the analysis along with the potential for interferences. Use of a stable-labeled analog of everolimus is the best choice to minimize variability or mitigate any potential interference in LC-MS/MS analysis.
EveroliMus-d4 Preparation Products And Raw materials
Raw materials
Preparation Products
EveroliMus-d4 Suppliers
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32344
- Advantage
- 50
- Tel
- 400-6206333 18521732826;
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25004
- Advantage
- 65
- Tel
- 020-81960175
- Fax
- +1-541-2553641
- min.he@cato-chem.com
- Country
- China
- ProdList
- 1958
- Advantage
- 55
- Tel
- 19138486554 18582380095
- Fax
- 0575-89298961
- sales@artisbio.com
- Country
- China
- ProdList
- 3066
- Advantage
- 58
- Tel
- 025-84622273 02584622273;
- kexin.zhou@haolvbiotech.com
- Country
- China
- ProdList
- 3021
- Advantage
- 58
- Tel
- +86-400-002-6226 13028896684
- sales@rrkchem.com
- Country
- China
- ProdList
- 55672
- Advantage
- 58
- Tel
- 0551-66336380 18956014586
- Fax
- 055166336380
- 983438788@qq.com
- Country
- China
- ProdList
- 2076
- Advantage
- 58
- Tel
- 17825480238
- Fax
- QQ 3008233717
- 3008233717@qq.com
- Country
- China
- ProdList
- 9844
- Advantage
- 12
- Tel
- 86-714-3992388
- overseasales1@yongstandards.com
- Country
- United States
- ProdList
- 14336
- Advantage
- 58
- Tel
- 2710913286@.com
- 1513643261@qq.com
- Country
- China
- ProdList
- 14253
- Advantage
- 58