ChemicalBook > CAS DataBase List > Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate

Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate

Product Name
Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate
CAS No.
205448-65-3
Chemical Name
Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate
Synonyms
methyl 4-hydroxy-7-methoxyquinoline-6-carboxylate;lenvaint-C;FMX14227-A2;Lenvatinib Impurity 62;Lenvatinib Intermediate3;Methyl 7-Methoxy-4-oxo-1;4-dihydroquinoline-6-carboxylate;Methyl 7-methoxy-4-oxo-1,4-dihydroquinoline-6-;1,4-dihydro-7-methoxy-4-oxo-6-quinolinecarboxylic;7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate
CBNumber
CB32714984
Molecular Formula
C12H11NO4
Formula Weight
233.22
MOL File
205448-65-3.mol
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Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate Property

Boiling point:
421.0±45.0 °C(Predicted)
Density 
1.267±0.06 g/cm3(Predicted)
storage temp. 
2-8°C, protect from light
pka
-0.53±0.50(Predicted)
Appearance
Off-white to light yellow Solid
InChI
InChI=1S/C12H11NO4/c1-16-11-6-9-7(10(14)3-4-13-9)5-8(11)12(15)17-2/h3-6H,1-2H3,(H,13,14)
InChIKey
TYKSVPGCVLNVIO-UHFFFAOYSA-N
SMILES
N1C2=C(C=C(C(OC)=O)C(OC)=C2)C(=O)C=C1
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Safety

HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific
Product number
OR470912
Product name
Methyl7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate
Packaging
1g
Price
$144
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-1-501
Product name
Methyl 7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate
Packaging
1g
Price
$159
Updated
2021/12/16
Apolloscientific
Product number
OR470912
Product name
Methyl7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate
Packaging
5g
Price
$507
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-1-501
Product name
Methyl 7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate
Packaging
5G
Price
$559
Updated
2021/12/16
AK Scientific
Product number
0005AP
Product name
Methyl7-methoxy-4-oxo-1,4-dihydro-6-quinolinecarboxylate
Packaging
10g
Price
$697
Updated
2021/12/16
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Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate Chemical Properties,Usage,Production

Synthesis

205448-64-2

205448-65-3

General procedure for the synthesis of methyl 7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate from methyl 4-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)methylamino)-2-methoxybenzoate: 5-((3-methoxy-4-methoxycarbonyloxyanilino)methylene-2,2-dimethyl-1,3-dioxane-4, 6-dione (10 g, 29.8 mmol) was suspended in DOWTHERM A (125 ml) and heated to 180-190 °C within 30 min. The raw material dissolved at 100°C and carbon dioxide began to be released at about 180°C. Heating was continued for 30 minutes and then stopped. As the reaction mixture cooled, the product gradually precipitated. When the temperature drops to 40°C, ether is added and the mixture is stirred for 30 minutes. The solid product was collected by filtration, washed with ether and dried under vacuum to afford 7-methoxy-6-methoxycarbonyl-1,4-dihydroquinolin-4-one (5.56 g, 80% yield). The structure of the product was confirmed by 1H NMR spectroscopy: (DMSO-d6) δ 3.80 (s, 3H); 3.85 (s, 3H); 5.95 (d, 1H); 7.00 (s, 1H); 7.85 (d, 1H); 8.40 (s, 1H); 11.6 (br s, 1H); MS-ESI: 234 [MH]+.

References

[1] Patent: US6809097, 2004, B1. Location in patent: Page column 67
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 6, p. 1649 - 1667
[3] Journal of Medicinal Chemistry, 2008, vol. 51, # 6, p. 1668 - 1680
[4] Patent: EP1724268, 2006, A1. Location in patent: Page/Page column 48
[5] Patent: EP3293177, 2018, A1. Location in patent: Paragraph 0199; 0201

Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate Suppliers

China 192 United Kingdom 1 United States 3 Global 196
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
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View Lastest Price from Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate 205448-65-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30
Nanjing Fred Technology Co., Ltd
Product
methyl 7-methoxy-4-oxo-1,4-dihy-droquinoline-6-carboxylate 205448-65-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-19
Career Henan Chemical Co
Product
Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate 205448-65-3
Price
US $100.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2018-07-31

205448-65-3, Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylateRelated Search:

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