isofebrifugin

isofebrifugin Property

Melting point:

129-130 °C

Boiling point:

519.8±58.0 °C(Predicted)

Density 

1.48±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

Solid

pka

12.01±0.20(Predicted)

color 

White to off-white

InChI

InChI=1S/C16H19N3O3/c20-15-11-4-1-2-5-12(11)18-10-19(15)9-16(21)8-13-14(22-16)6-3-7-17-13/h1-2,4-5,10,13-14,17,21H,3,6-9H2/t13-,14-,16-/m0/s1

InChIKey

YLYLCQRQSRDSQR-DZKIICNBSA-N

SMILES

N1C2=C(C=CC=C2)C(=O)N(C[C@@]2(O)O[C@@]3([H])CCCN[C@@]3([H])C2)C=1

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

isofebrifugin Chemical Properties,Usage,Production

Chemical Properties

White powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the dried root of Dichroa febrifuga Lour.

Uses

Isofebrifugine is a natural quinazolinone alkaloid with important physiological activities and good pharmacological effects. Antimalarial effect[1].

References

[1] Kobayashi S, et al. Catalytic Asymmetric Synthesis of Antimalarial Alkaloids Febrifugine and Isofebrifugine and Their Biological Activity.J Org Chem. 1999 Sep 3;64(18):6833-6841. DOI:10.1021/jo990877k