N-Vinyl-2-pyrrolidone
Description- Product Name
- N-Vinyl-2-pyrrolidone
- CAS No.
- 88-12-0
- Chemical Name
- N-Vinyl-2-pyrrolidone
- Synonyms
- NVP;N-VINYLPYRROLIDONE;1-Vinylpyrrolidin-2-one;Vinylpyrrolidone;1-VINYL-2-PYRROLIDONE;1-VINYL-2-PYRROLIDINONE;2-Pyrrolidinone, 1-ethenyl-;N-VINYL-2-PYRROLIDINONE;N-VinyPyrrolidone;N-Vinylpyrrolidinone
- CBNumber
- CB3272024
- Molecular Formula
- C6H9NO
- Formula Weight
- 111.14
- MOL File
- 88-12-0.mol
N-Vinyl-2-pyrrolidone Property
- Melting point:
- 13-14 °C
- Boiling point:
- 92-95 °C11 mm Hg(lit.)
- Density
- 1.04 g/mL at 25 °C(lit.)
- vapor density
- 3.8 (vs air)
- vapor pressure
- 0.1 mm Hg ( 24 °C)
- refractive index
- n20/D 1.512(lit.)
- Flash point:
- 201 °F
- storage temp.
- Store below +30°C.
- solubility
- 52.1g/l soluble
- form
- Liquid
- pka
- -0.34±0.20(Predicted)
- color
- Clear colorless to yellow
- PH
- 9-10 (100g/l, H2O, 20℃)
- explosive limit
- 1.4-10%(V)
- Water Solubility
- miscible
- Merck
- 14,7697
- BRN
- 110513
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChIKey
- WHNWPMSKXPGLAX-UHFFFAOYSA-N
- LogP
- 0.4 at 25℃
- CAS DataBase Reference
- 88-12-0(CAS DataBase Reference)
- NIST Chemistry Reference
- N-Vinylpyrrolidone(88-12-0)
- IARC
- 3 (Vol. 19, Sup 7, 71) 1999
- EPA Substance Registry System
- N-Vinyl-2-pyrrolidone (88-12-0)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-37-40-41-48/20
- Safety Statements
- 26-36/37/39
- RIDADR
- UN 2810 6.1/PG 3
- WGK Germany
- 1
- RTECS
- UY6107000
- Autoignition Temperature
- 685 °F
- TSCA
- TSCA listed
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29337900
- Hazardous Substances Data
- 88-12-0(Hazardous Substances Data)
- Toxicity
- LD50 orally in Rabbit: 1022 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
H335May cause respiratory irritation
H351Suspected of causing cancer
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- V3409
- Product name
- 1-Vinyl-2-pyrrolidinone
- Purity
- contains sodium hydroxide as inhibitor, ≥99%
- Packaging
- 1kg
- Price
- $155
- Updated
- 2024/03/01
- Product number
- PHR1740
- Product name
- 1-Vinyl-2-pyrrolidinone
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 200mg
- Price
- $377
- Updated
- 2024/03/01
- Product number
- 8.08518
- Product name
- 1-Vinyl-2-pyrrolidone
- Purity
- (stabilized with N,N′-di-sec-butyl-1,4-phenylenediamine) for synthesis
- Packaging
- 5ml
- Price
- $35.3
- Updated
- 2024/03/01
- Product number
- 8.08518
- Product name
- 1-Vinyl-2-pyrrolidone
- Purity
- (stabilized with N,N′-di-sec-butyl-1,4-phenylenediamine) for synthesis
- Packaging
- 250ML
- Price
- $53.3
- Updated
- 2024/03/01
- Product number
- V0026
- Product name
- 1-Vinyl-2-pyrrolidone (stabilized with N,N'-Di-sec-butyl-p-phenylenediamine)
- Purity
- >99.0%(GC)
- Packaging
- 25mL
- Price
- $27
- Updated
- 2024/03/01
N-Vinyl-2-pyrrolidone Chemical Properties,Usage,Production
Description
N-vinyl-2-pyrrolidone (NVP) is commonly used as a reactive diluent for radiation curing in UV-coating, UV-inks, and UV adhesives. It is used as a monomer to produce water soluble polyvinylpyrrolidone (PVP) with uses in pharmaceuticals, oil field, cosmetics, food additives & adhesives. It is used in the manufacture of copolymers with, for example, acrylic acid, acrylates, vinyl acetate and acrylonitrile and in the synthesis of phenolic resins.
Chemical Properties
Colorless liquid. Combustible.
Uses
1-Vinyl-2-pyrrolidinone is used in the preparation of NMDA receptor antagonists. Also used in the synthesis of copolymers used to stabilize rhodium nanoclusters.
Uses
A pyrrolidine used for biochemical research
Definition
ChEBI: N-Vinyl-2-pyrrolidone is a member of pyrrolidin-2-ones.
Application
N-Vinyl-2-pyrrolidone (NVP) is an important precursor and intermediate for process auxiliaries and additives. The main areas of use are the production of polyvinylpyrrolidone and copolymers, the preferred comonomers being vinyl acetate and methyl acrylate. Ca. 10–15% of the monomer is used in the pharmaceutical industry for the production of a polyvinylpyrrolidone–iodine complex used as a disinfectant. NVP is also used as a reactive solvent for UV-curable resins for the production of printing inks and paints as paper and textile auxiliaries, and as an additive in the cosmetics industry.
Production Methods
Industrially, N-Vinyl-2-pyrrolidone (NVP) is produced by reacting 2-pyrrolidone with acetylene in highpressure autoclaves at 130–170 ℃ and pressures of up to 2.6 MPa. Vinylation proceeds in the liquid phase and is catalyzed by 2-pyrrolidone–potassium. The salt is obtained by adding 1–5% potassium hydroxide or caustic potash solution to fresh pyrrolidone and removing excess water by vacuum distillation (batchwise or continuously). The vinylation reaction takes place in a liquid-phase tube or loop reactor, or in a gas-phase reactor. To avoid the danger of acetylene explosions, nitrogen or propane mixtures of acetylene are used instead of pure acetylene. After the vinylation, the crude product obtained is purified by multistep vacuum distillation. Unreacted 2-pyrrolidone and derivatives can be recycled. Excess acetylene is removed by distillation and can also be recycled to the process. ?Another industrially important synthetic route is based on N-(1-hydroxyethyl)-2-pyrrolidone (HEP). In this process, HEP is dehydrated in the gas phase in a heterogeneously catalyzed reaction at 320–400 ℃ and 10 kPa. The obtained crude NVP is purified by vacuum distillation or crystallization.
General Description
1-Vinyl-2-pyrrolidinone is a colorless to yellow liquid, with a characteristic odor. Its melting point is around 13.5oC and boils at about 90-92oC. VP is completely miscible in water and in most organic solvents but partially miscible in aliphatic hydrocarbons. Industrial production of VP by reacting 2-pyrrolidone with acetylene at high pressure and temperature has been reported. The vinylation process proceeds in liquid phase and is catalyzed by 3-pyrrolidone -potassium hydroxide.
Chemical Reactivity
N-Vinyl-2-pyrrolidone (NVP) is stable toward alkalis at room temperature. Above 0 ℃ it is cleaved by aqueous mineral acids into acetaldehyde and 2-pyrrolidone; the latter reacts with an excess of NVP to give 1,1'-ethylidene-bis-2- pyrrolidone. Protic compounds such as amides, thiols, alcohols, and phenols add to the double bond according to the Markovnikov rule, for example, N-(1-phenoxyethyl)-2-pyrrolidone is formed with phenol. Catalytic hydrogenation produces N-ethyl-2-pyrrolidone. Hydroformylation on rhodium catalysts forms 2-N-(2-pyrrolidonyl)-propanal as the major product. On prolonged standing, particularly in warm conditions, NVP tends to polymerize. Industrially, N-Vinyl-2-pyrrolidone (NVP) is converted into polyvinylpyrrolidone using radical initiators.
Safety Profile
Confirmed carcinogen. Moderately toxic by ingestion, inhalation, and skin contact. A severe eye irritant. Probably irritating and narcotic in high concentrations. Combustible when exposed to heat or flame; can react vigorously with oxibzing materials. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits highly toxic fumes of NOx.
storage
N-Vinyl-2-pyrrolidone (NVP) must be protected from heat and direct sunlight. Even in closed containers NVP can only be stored for a limited period because it tends to polymerize. Stabilizers are therefore added. N,N'-Bis(1-methylpropyl)-1,4-benzenediamine [101-96-2] is an important, NVP-soluble stabilizer that does not interfere with further processing. Use of this stabilizer allows the product to be stored for ca. 300 d at 20 ℃, and ca. 150 d at 25 ℃. Stabilization with solid sodium hydroxide that can be easily filtered off is not as efficient. Storage at temperatures close to the melting point results in separation of NVP from the stabilizer due to repeated solidification and melting. This shortens the shelf life considerably and can lead to uncontrolled polymerization. Solidified NVP must therefore be molten carefully in a water bath (max. 40 ℃) or at room temperature (max. 30 ℃) and homogenized by continuous agitation.
N-Vinyl-2-pyrrolidone Preparation Products And Raw materials
Raw materials
Preparation Products
N-Vinyl-2-pyrrolidone Suppliers
- Tel
- 19371278702
- n13164103386@163.com
- Country
- China
- ProdList
- 2928
- Advantage
- 58
- Tel
- 551-65418679 15837135945
- Fax
- 0551-65418697
- info@tnjchem.com
- Country
- China
- ProdList
- 1889
- Advantage
- 62
- Tel
- 027-18971353-902 18971353902
- 2242508613@qq.com
- Country
- China
- ProdList
- 7871
- Advantage
- 58
- Tel
- 10106090
- jjlchem2@163.com
- Country
- China
- ProdList
- 9981
- Advantage
- 58
- Tel
- 13165963866
- cxxny88882022@163.com
- Country
- China
- ProdList
- 31
- Advantage
- 58
- Tel
- 13517196568
- 375665891@qq.com
- Country
- China
- ProdList
- 470
- Advantage
- 58
- Tel
- 022-022-58788819 13602056505
- Fax
- 022-60321328
- linlin@realetchem.com
- Country
- China
- ProdList
- 61
- Advantage
- 55
- Tel
- 022-66880623
- Fax
- 86(0)22-66880086
- sales@tjzxchem.com
- Country
- China
- ProdList
- 613
- Advantage
- 60
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 94657
- Advantage
- 76
- Tel
- 021-61259108 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 010-89508211 18501085097
- Fax
- 010-89508210
- sales.bj@hwrkchemical.com
- Country
- China
- ProdList
- 8418
- Advantage
- 55
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44689
- Advantage
- 61
- Tel
- 010-82967028 13552068683
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12390
- Advantage
- 60
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11655
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42958
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 15527768850
- 1791901229@qq.com
- Country
- China
- ProdList
- 8843
- Advantage
- 52
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18738
- Advantage
- 57
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12984
- Advantage
- 57
- Tel
- 400-1166-196 18981987031
- Fax
- 028-84555506 800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 11707
- Advantage
- 57
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7811
- Advantage
- 57
- Tel
- 400-188-0725 +86 21 34310725 13611771617
- Fax
- +86 21 34311076
- Country
- China
- ProdList
- 2002
- Advantage
- 57
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14435
- Advantage
- 57
- Tel
- 86-21-63210123
- Fax
- 86-21-63290778 86-21-63218885
- sj_scrc@sinopharm.com
- Country
- China
- ProdList
- 9815
- Advantage
- 79
- Tel
- +86 (573) 82222445 (0)18006601000 452520369
- Fax
- +86 (573) 82222643
- sales@maya-r.com
- Country
- China
- ProdList
- 11707
- Advantage
- 57
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- Fax
- 021-57711696
- marketing_china@spectrumchemical.com
- Country
- China
- ProdList
- 9658
- Advantage
- 60
- Tel
- 027-59207852 13308628970
- Fax
- QQ3130921841
- buy@fortunachem.com
- Country
- China
- ProdList
- 2872
- Advantage
- 58
- Tel
- 4008-755-333 18080918076
- Fax
- 028-86757656
- 800078821@qq.com
- Country
- China
- ProdList
- 9718
- Advantage
- 55
- Tel
- 0755-4000505016 13380397412
- Fax
- 0755 28094224
- 3001272453@qq.com
- Country
- China
- ProdList
- 5047
- Advantage
- 50
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9865
- Advantage
- 52
- Tel
- 800-810-5118
- Fax
- +86-10-84193589
- cnchemical@thermofisher.com
- Country
- China
- ProdList
- 17770
- Advantage
- 75
- Tel
- 400-810-7969 010-59572699
- Fax
- 010-59572688
- ningzi.li@inno-chem.com.cn
- Country
- China
- ProdList
- 6134
- Advantage
- 55
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 18017383231 18017383231
- Fax
- qq：2817624287
- lyh_antaeus@163.com
- Country
- China
- ProdList
- 9347
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- 400-400-6206333 18521732826
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 021-61552785
- Fax
- 021-55660885
- sales@shshiji.com
- Country
- China
- ProdList
- 9545
- Advantage
- 55
- Tel
- 021-69180038
- Fax
- 0086-21-39177059
- zhuoruichem@163.com
- Country
- China
- ProdList
- 105
- Advantage
- 58
- Tel
- 86-0755-86635001
- Fax
- 86-0755-22642228
- cantotech@126.com
- Country
- China
- ProdList
- 4566
- Advantage
- 55
- Tel
- 86-13605431940 13605431940
- Fax
- 0086-0543-2240079
- zpmxchemical@126.com
- Country
- China
- ProdList
- 1999
- Advantage
- 62
- Tel
- 021-61995394 18916691159
- chemicalsea@163.com
- Country
- China
- ProdList
- 1972
- Advantage
- 58
- Tel
- 0570-3066667
- Fax
- 0570-3063388
- Country
- China
- ProdList
- 3930
- Advantage
- 58
- Tel
- 400-8706899
- Fax
- 400-8706899
- hysj_bj.com
- Country
- China
- ProdList
- 3583
- Advantage
- 55
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- 422131432@qq.com
- Country
- China
- ProdList
- 9978
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41462
- Advantage
- 60
- Tel
- 86-21-51086038
- Fax
- 86-21-51861608
- Country
- China
- ProdList
- 2930
- Advantage
- 58
- Tel
- 010-51268198
- Fax
- 010-63833209
- leadershipchem@126.com
- Country
- China
- ProdList
- 2546
- Advantage
- 58
- Tel
- 0371-13526885213 15637198702
- Fax
- 0371-63709726
- xpkchem@163.com
- Country
- China
- ProdList
- 3990
- Advantage
- 58
- Tel
- 021-58958189
- Fax
- 021-58957967
- wouchina@126.com
- Country
- China
- ProdList
- 2666
- Advantage
- 55
View Lastest Price from N-Vinyl-2-pyrrolidone manufacturers
- Product
- N-Vinyl-2-pyrrolidone 88-12-0
- Price
- US $0.00/KG
- Min. Order
- 200KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-01
- Product
- N-Vinyl-2-pyrrolidone NVP 88-12-0
- Price
- US $99.00-35.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-15
- Product
- N-Vinyl-2-pyrrolidone 88-12-0
- Price
- US $10.00-7.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 10 tons
- Release date
- 2024-06-14