AZD8186
- Product Name
- AZD8186
- CAS No.
- 1627494-13-6
- Chemical Name
- AZD8186
- Synonyms
- CS-1576;AZD8186;EOS-61540;AZD 8186, >=98%;AZD-8186;AZD 8186;AZD8186;AZD-8186;AZD 8186;8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide;(R)-8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide;8-[(1R)-1-[(3,5-Difluorophenyl)amino]ethyl]-N,N-dimethyl-2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-6-carboxamide;4H-1-Benzopyran-6-carboxamide, 8-[(1R)-1-[(3,5-difluorophenyl)amino]ethyl]-N,N-dimethyl-2-(4-morpholinyl)-4-oxo-
- CBNumber
- CB32737158
- Molecular Formula
- C24H25F2N3O4
- Formula Weight
- 457.47
- MOL File
- 1627494-13-6.mol
AZD8186 Property
- Melting point:
- 226-227°C
- Boiling point:
- 645.2±55.0 °C(Predicted)
- Density
- 1.351±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
- pka
- 2.56±0.50(Predicted)
- form
- Solid
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 17384
- Product name
- AZD 8186
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 17384
- Product name
- AZD 8186
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 17384
- Product name
- AZD 8186
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 17384
- Product name
- AZD 8186
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $343
- Updated
- 2024/03/01
- Product number
- A808185
- Product name
- AZD8186
- Packaging
- 100mg
- Price
- $505
- Updated
- 2021/12/16
AZD8186 Chemical Properties,Usage,Production
Uses
AZD 8186 is a potent and selective inhibitor of PI3Kβ and PI3Kδ for the treatment of PTEN-deficient cancers.
Biological Activity
the pi3k-akt signaling pathway plays a critical role in cell growth, proliferation, motility, and survival. in human cancer, this pathway is activated by several mechanisms, including somatic mutations, deletions, and amplifications. class i pi3ks are further divided into class ia enzymes (pi3kα, pi3kβ, and pi3kδ) and class ib enzymes (pi3kγ). azd8186 is a potent and selective inhibitor of pi3kβ and pi3kδ.
in vitro
azd8186 gave potent inhibition of p-akt in cells sensitive to pi3kβ inhibition and in cells sensitive to pi3kδ inhibition but not to cells sensitive to pi3kα inhibition. the overall kinase selectivity of azd8186 was evaluated in several panels of recombinant protein and lipid kinase assays. 13 did not show significant activity against a panel of 59 protein kinases tested at 1 μm [1].
in vivo
the antitumor activity of azd8186 was evaluated in the pten deficient pc3 prostate tumor xenograft model in nude mice, either at 100 mg/kg b.i.d. without abt coadministration, or at 60, 30, and 10 mg/mg b.i.d. with abt coadministration. higher inhibition was seen in the 60 and 30 mg/kg groups with abt coadministration than in the 100 mg/kg group without abt coadministration [1].
IC 50
0.003 μm for pi3kβ and 0.017 μm for pi3kδ
AZD8186 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from AZD8186 manufacturers
- Product
- AZD8186 1627494-13-6
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23