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BD 1047 dihydrobromide

Product Name
BD 1047 dihydrobromide
CAS No.
138356-21-5
Chemical Name
BD 1047 dihydrobromide
Synonyms
169592;BD1047.2HBr;BD 1047 HBr;BD-1047;BD 1047;BD1047.2HBr(1K/g);BD 1047 (hydrobromide);BD-1047 dihydrobromide, 10 mM in DMSO;BD-1047 dihydrobromide (BD1047 dihydrobromide);BD 1047 dihydrobromide, sigma1 receptor antagonist;N1-(3,4-DICHLOROPHENETHYL)-N1,N2,N2-TRIMETHYLETHANE-1,2-DIAMINE 2HBR
CBNumber
CB32755978
Molecular Formula
C13H22Br2Cl2N2
Formula Weight
437.04118
MOL File
138356-21-5.mol
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BD 1047 dihydrobromide Property

storage temp. 
Inert atmosphere,2-8°C
solubility 
H2O: >5mg/mL
form 
powder
color 
white
Water Solubility 
H2O: >5mg/mL
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
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Safety

Hazard Codes 
Xi
Risk Statements 
37/38-41
Safety Statements 
26-36/37
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B8562
Product name
BD 1047 dihydrobromide
Purity
≥95% (HPLC)
Packaging
5mg
Price
$117
Updated
2025/07/31
Sigma-Aldrich
Product number
B8562
Product name
BD 1047 dihydrobromide
Purity
≥95% (HPLC)
Packaging
25mg
Price
$462
Updated
2025/07/31
Cayman Chemical
Product number
22928
Product name
BD 1047 (hydrobromide)
Purity
≥98%
Packaging
5mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
22928
Product name
BD 1047 (hydrobromide)
Purity
≥98%
Packaging
10mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
22928
Product name
BD 1047 (hydrobromide)
Purity
≥98%
Packaging
25mg
Price
$235
Updated
2024/03/01
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BD 1047 dihydrobromide Chemical Properties,Usage,Production

Description

BD 1047 is a selective antagonist of sigma-1 (σ1) receptors (Ki = 0.9 nM in a radioligand binding assay). It is selective for σ1 receptors with binding affinity values greater than 10,000 nM for human recombinant dopamine, opioid, PCP, and serotonin receptors in vitro. In vivo, pretreatment with BD 1047 protects against convulsions and lethality induced by cocaine (Item Nos. 16186 | ISO60176) and reduces cocaine-induced locomotor activity. It reduces dystonias induced by the σ receptor agonists haloperidol and di-o-tolylguanidine (DTG) in rats in a dose-dependent manner. In vivo administration of BD 1047 also attenuates mechanical allodynia and microglial activation in a rat model of bone cancer pain.

Uses

BD 1047 dihydrobromide is an σ1 receptor antagonist with higher affinity than BD 1063.

in vivo

BD-1047 (dihydrobromide) (1-10 mg/kg; i.p.) decreases the Apomorphine (APO)-induced climbing behavior at the dose of 10 mg/kg in mice[1].
BD-1047 (dihydrobromide) counteracts the antidepressant-like effect induced by co-administration of pramipexole and sertraline (but not pramipexole and fluoxetine)[3].
BD-1047 (dihydrobromide) reduces the increasing expression of pNR1, and reverses the Sig-1 R agonists potentiated NMDA-induced pain behaviour and pNR1 immunoreactivity[4].

Animal Model:Male Albino Swiss mice (50 days old, 25–28 g)[1]
Dosage:1 mg/kg, 3 mg/kg, 10 mg/kg
Administration:Intraperitoneal injection
Result:Decreased the APO-induced climbing at the dose of 10 mg/kg in mice.

IC 50

Sigma 1 Receptor

storage

Desiccate at +4°C

References

[1] RAE R. MATSUMOTO . Characterization of two novel σ receptor ligands: antidystonic effects in rats suggest σ receptor antagonism[J]. European journal of pharmacology, 1995, 280 3: Pages 301-310. DOI:10.1016/0014-2999(95)00208-3
[2] KARI A. MCCRACKEN . Two novel σ receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity[J]. European journal of pharmacology, 1999, 370 3: Pages 225-232. DOI:10.1016/s0014-2999(99)00113-2
[3] TIEYING SONG. Role of sigma 1 receptor in high fat diet-induced peripheral neuropathy.[J]. Biological Chemistry, 2017, 398 10: 1141-1149. DOI:10.1515/hsz-2017-0117
[4] YOUNG CHAN JEONG  Young B K  Ji Seon Son. The spinal antinociceptive mechanism determined by systemic administration of BD1047 in zymosan-induced hyperalgesia in rats[J]. Brain Research Bulletin, 2015, 119: Pages 93-100. DOI:10.1016/j.brainresbull.2015.07.006
[5] DAE-HYUN ROH S Y Y. Sigma-1 receptor antagonist, BD1047 reduces nociceptive responses and phosphorylation of p38 MAPK in mice orofacial formalin model.[J]. Accounts of Chemical Research, 2014: 145-151. DOI:10.1248/bpb.b13-00690
[6] SHANSHAN ZHU. Sigma-1 Receptor Antagonist BD1047 Reduces Mechanical Allodynia in a Rat Model of Bone Cancer Pain through the Inhibition of Spinal NR1 Phosphorylation and Microglia Activation.[J]. Mediators of Inflammation, 2015, 2015 1: 265056. DOI:10.1155/2015/265056

BD 1047 dihydrobromide Preparation Products And Raw materials

Raw materials

Preparation Products

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BD 1047 dihydrobromide Suppliers

China 82 United Kingdom 1 United States 15 Global 98
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
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sales@boylechem.com
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China
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2922
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ChemShuttle, Inc.
Tel
0510-83588313-811 18800520310
Email
sales@chemshuttle.com
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China
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2999
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62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
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Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
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China
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7552
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61
MedChemexpress LLC
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021-58955995
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609-228-5909
Email
sales@medchemexpress.cn
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United States
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4861
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58
AdooQ Bioscience CHINA
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025-58849295 18951903616;
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025-68650336
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info@adooq.cn
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China
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2990
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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China
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4769
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Guangzhou Zhiya Chemdrugs Co.,Ltd
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18122150900
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QQ:2869377561
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sculk28@163.com
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China
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ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
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China
ProdList
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
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View Lastest Price from BD 1047 dihydrobromide manufacturers

Career Henan Chemical Co
Product
BD 1047 dihydrobromide 138356-21-5
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-30

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