5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE

Product Name: 5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE
CAS No.: 824-52-2
Chemical Name: 5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE
Synonyms: 5-METHYL-7-AZAINDOLE;5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE;1H-Pyrrolo[2,3-b]pyridine, 5-methyl-
CBNumber: CB3279018
Molecular Formula: C8H8N2
Formula Weight: 132.16
MOL File: 824-52-2.mol

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5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE Property

Melting point:: 138-139 °C
Boiling point:: 365.4±15.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
form: solid
pka: 7.94±0.20(Predicted)
Appearance: White to light yellow Solid
InChI: InChI=1S/C8H8N2/c1-6-4-7-2-3-9-8(7)10-5-6/h2-5H,1H3,(H,9,10)
InChIKey: DJCJHFFRHKGOCQ-UHFFFAOYSA-N
SMILES: C12NC=CC1=CC(C)=CN=2

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-38-41
Safety Statements: 26-39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000939
Product name: 5-Methyl-1H-pyrrolo[2,3-b]pyridine
Purity: Aldrich
Packaging: 1g
Price: $817
Updated: 2025/07/31

Matrix Scientific

Product number: 026236
Product name: 5-Methyl-1H-pyrrolo[2,3-b]pyridine
Packaging: 50mg
Price: $25
Updated: 2021/12/16

Apolloscientific

Product number: OR964572
Product name: 5-Methyl-1H-pyrrolo[2,3-b]pyridine
Purity: 98%
Packaging: 250mg
Price: $130
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-1-HE
Product name: 5-Methyl-1H-pyrrolo[2,3-b]pyridine
Purity: 98%
Packaging: 250mg
Price: $208
Updated: 2021/12/16

Apolloscientific

Product number: OR964572
Product name: 5-Methyl-1H-pyrrolo[2,3-b]pyridine
Purity: 98%
Packaging: 1g
Price: $295
Updated: 2021/12/16

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5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE Chemical Properties,Usage,Production

Chemical Properties

5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE is Light yellow solid

Uses

5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE is an intermediate for preparation of pyrrolopyridine compounds as protein kinase modulators useful in treatment of diseases associated with aberrant activity of protein kinases.

Synthesis

500903-95-7

824-52-2

The general procedure for the synthesis of 5-methyl-7-azaindole from 5-methyl-3-((trimethylmethylsilyl)alkynyl)pyridin-2-amine was as follows: 5-methyl-3-((trimethylsilyl)alkynyl)pyridin-2-amine (9.8 g, 48.0 mmol) and N-methylpyrrolidinone (50 mL) were added to a dry three-necked flask. Under ice bath conditions, sodium hydride (60% dispersed in mineral oil, 2.8 g, 59 mmol) was slowly added, followed by heating the reaction mixture to 100 degrees Celsius and holding for 10 minutes. Upon completion of the reaction, the mixture was cooled to room temperature and saturated ammonium chloride solution (50 mL) was slowly added to quench the reaction. Extraction was performed with ethyl acetate (50 mL x 3) and the organic phases were combined. The organic phase was washed sequentially with water (100 mL) and saturated brine (100 mL) and then dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated to dryness in a rotary evaporator to obtain the crude product. The crude product was recrystallized with ethyl acetate (10 mL) to give 5-methyl-7-azaindole (5.1 g, 38.6 mmol, 80% yield) as a white solid.

References

[1] Patent: CN107056781, 2017, A. Location in patent: Paragraph 0008
[2] Patent: WO2017/133667, 2017, A1. Location in patent: Page/Page column 120
[3] Patent: US2009/253679, 2009, A1. Location in patent: Page/Page column 41
[4] Patent: WO2008/4117, 2008, A1

5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE Suppliers

Canada 1 China 90 China Hong Kong 1 India 1 United States 10 Global 103

Pure Chemistry Scientific Inc.

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View Lastest Price from 5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE manufacturers

Career Henan Chemical Co

Product: 5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE 824-52-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-17

824-52-2, 5-METHYL-1H-PYRROLO[2,3-B]PYRIDINERelated Search:

5-METHYL-7-AZAINDOLE

5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE

1H-Pyrrolo[2,3-b]pyridine, 5-methyl-

824-52-2

Aromatics

Heterocycles

Heterocycle-Pyridine series

Heterocycles series